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Angelica tenuissima Nakai Ameliorates Cognitive Impairment and Promotes Neurogenesis in Mouse Model of Alzheimer’s Disease
Angelica tenuissima Nakai Ameliorates Cognitive Impairment and Promotes Neurogenesis in Mouse Model of Alzheimer’s Disease
- 中国结合医学杂志（英文版） 2018年24卷第5期 页码：378-384
- Affiliations：
Department of Psychiatry, Hospital of Korean Medicine, Kyung Hee University Medical Center, Seoul, South Korea
- Author bio：
- Funds：Supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (No. NRF-2013R1A1A1063477)
DOI：10.1007/s11655-017-2812-2
中图分类号：纸质出版日期：2018，
网络出版日期：2017-6-3，
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Choi, M., Lee, Y. & Cho, SH. Angelica tenuissima Nakai Ameliorates Cognitive Impairment and Promotes Neurogenesis in Mouse Model of Alzheimer’s Disease., Chin. J. Integr. Med. 24, 378–384 (2018). https://doi.org/10.1007/s11655-017-2812-2
Minji Choi, Younghyurk Lee, Seung-Hun Cho. Angelica tenuissima Nakai Ameliorates Cognitive Impairment and Promotes Neurogenesis in Mouse Model of Alzheimer’s Disease[J]. Chinese Journal of Integrative Medicine, 2018,24(5):378-384.
Choi, M., Lee, Y. & Cho, SH. Angelica tenuissima Nakai Ameliorates Cognitive Impairment and Promotes Neurogenesis in Mouse Model of Alzheimer’s Disease., Chin. J. Integr. Med. 24, 378–384 (2018). https://doi.org/10.1007/s11655-017-2812-2 DOI：
Minji Choi, Younghyurk Lee, Seung-Hun Cho. Angelica tenuissima Nakai Ameliorates Cognitive Impairment and Promotes Neurogenesis in Mouse Model of Alzheimer’s Disease[J]. Chinese Journal of Integrative Medicine, 2018,24(5):378-384. DOI： 10.1007/s11655-017-2812-2.
摘要
To research Angelica tenuissima Nakai (ATN) for use in novel Alzheimer’s disease (AD) therapeutics. The effect of a 30% ethanol extract of ATN (KH032) on AD-like cognitive impairment and neuropathological and neuroinflammatory changes induced by bilateral intracerebroventricular injections of β-amyloid (Aβ) peptide (Aβ1-42) was investigated. Male C57Bl/6 mice were randomly divided into 4 groups
10 in each group. KH032-treated groups were administrated with a low or high dose of KH032 (50 and 200 mg/kg
respectively)
intragastrically for 16 days; distilled water was applied in the sham and negative groups. Open fifield test
Y maze and Morris water maze test were used for behavior test and cognitive ability. In addition
the neuroprotective effects of KH032 in Aβ1-42-infused mice on the histopathological markers [neuronspecific nuclear protein (NeuN)
Aβ1-42] of neurodegeneration were examined. The levels of glial fibrillary acidic protein (GFAP)
NeuN
phosphorylation extracellular signal-regulated kinase (ERK)/ERK
brain-derived neurotrophic factor (BDNF)
phosphorylation cAMP response element-binding (CREB)/CREB protein expression were measured by Western blot. KH032 treatment ameliorated cognitive impairments
reduced the overexpression of Aβ1-42
and inhibited neuronal loss and neuroinflammatory response in the Aβ1-42-infused mice. Moreover
KH032 treatment enhanced BDNF expression levels in the hippocampus. Finally
KH032 treatment increased phosphorylation of ERK1/2 and CREB
vital for ERK-CREB signaling. KH032 attenuated cognitive defificits in the Aβ1-42-infused mice by increasing BDNF expression and ERK1/2 and CREB phosphorylation and inhibiting neuronal loss and neuroinflflammatory response
suggesting that KH032 has therapeutic potential in neurodegenerative disorders such as AD.
Abstract
To research Angelica tenuissima Nakai (ATN) for use in novel Alzheimer’s disease (AD) therapeutics. The effect of a 30% ethanol extract of ATN (KH032) on AD-like cognitive impairment and neuropathological and neuroinflammatory changes induced by bilateral intracerebroventricular injections of β-amyloid (Aβ) peptide (Aβ1-42) was investigated. Male C57Bl/6 mice were randomly divided into 4 groups
10 in each group. KH032-treated groups were administrated with a low or high dose of KH032 (50 and 200 mg/kg
respectively)
intragastrically for 16 days; distilled water was applied in the sham and negative groups. Open fifield test
Y maze and Morris water maze test were used for behavior test and cognitive ability. In addition
the neuroprotective effects of KH032 in Aβ1-42-infused mice on the histopathological markers [neuronspecific nuclear protein (NeuN)
Aβ1-42] of neurodegeneration were examined. The levels of glial fibrillary acidic protein (GFAP)
NeuN
phosphorylation extracellular signal-regulated kinase (ERK)/ERK
brain-derived neurotrophic factor (BDNF)
phosphorylation cAMP response element-binding (CREB)/CREB protein expression were measured by Western blot. KH032 treatment ameliorated cognitive impairments
reduced the overexpression of Aβ1-42
and inhibited neuronal loss and neuroinflammatory response in the Aβ1-42-infused mice. Moreover
KH032 treatment enhanced BDNF expression levels in the hippocampus. Finally
KH032 treatment increased phosphorylation of ERK1/2 and CREB
vital for ERK-CREB signaling. KH032 attenuated cognitive defificits in the Aβ1-42-infused mice by increasing BDNF expression and ERK1/2 and CREB phosphorylation and inhibiting neuronal loss and neuroinflflammatory response
suggesting that KH032 has therapeutic potential in neurodegenerative disorders such as AD.
关键词
Alzheimer’s diseaseAngelica tenuissima Nakaibeta amyloidcognitive impairmentneurogenesis
Keywords
Alzheimer’s diseaseAngelica tenuissima Nakaibeta amyloidcognitive impairmentneurogenesis
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