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Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups
Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups
- 中国结合医学杂志（英文版） 2017年23卷第12期 页码：943-947
- Affiliations：
Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea
- Author bio：
- Funds：Supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF- 2014R1A5A2009936)
DOI：10.1007/s11655-017-2827-8
中图分类号：纸质出版日期：2017，
网络出版日期：2017-10-6，
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Kim, D., Bae, CH., Jun, Y.L. et al. Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups., Chin. J. Integr. Med. 23, 943–947 (2017). https://doi.org/10.1007/s11655-017-2827-8
Dongsoo Kim, Chang-Hwan Bae, Ye Lee Jun, et al. Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups[J]. Chinese Journal of Integrative Medicine, 2017,23(12):943-947.
Kim, D., Bae, CH., Jun, Y.L. et al. Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups., Chin. J. Integr. Med. 23, 943–947 (2017). https://doi.org/10.1007/s11655-017-2827-8 DOI：
Dongsoo Kim, Chang-Hwan Bae, Ye Lee Jun, et al. Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups[J]. Chinese Journal of Integrative Medicine, 2017,23(12):943-947. DOI： 10.1007/s11655-017-2827-8.
摘要
To investigate the potential alleviating effects of acupuncture on maternal separation (MS)-induced changes in plasma pro-inflammatory cytokine levels of rat pups. On postnatal day 15
rat pups were randomly assigned to 4 groups (n=6 per group) using a random number table: normal
MS
MS with acupuncture stimulation at Shenmen (HT 7) acupoint (MS+HT 7)
and MS with acupuncture stimulation at Chengshan (BL 57) acupoint (MS+BL 57) groups. Rat pups in the normal group were housed with their mothers under standard conditions; those in the MS
MS+HT 7 and MS+BL 57 groups were maternally separated and individually maintained. Acupuncture stimulation was performed at HT 7 or BL 57 acupoints once a day for 7 consecutive days. A tail suspension test was performed to measure immobility time of rats and the plasma was collected on postnatal day 21
then levels of corticosterone (CORT)
interleukin (IL)-1β
IL-6 and glial cell-derived neurotrophic factor (GDNF) in plasma were measured. Compared with the normal group
the immobility time and the plasma levels of CORT
IL-1β
IL-6 and GDNF in the MS group were significantly increased (P<0.05 or P<0.01). Compared with the MS group
the immobility time and the plasma levels of CORT
IL-1β
IL-6 and GDNF were significantly reduced in the MS+HT 7 group (P<0.05 or P<0.01). Moreover
the immobility time and plasma levels of IL-1β and IL-6 in the MS+HT 7 group were significantly lower than those in the MS+BL 57 group (P<0.05). Acupuncture stimulation at HT 7 can alleviate the behavioral impairment and changes of the cytokines by MS
indicating that acupuncture can help to relieve MS-induced depression.
Abstract
To investigate the potential alleviating effects of acupuncture on maternal separation (MS)-induced changes in plasma pro-inflammatory cytokine levels of rat pups. On postnatal day 15
rat pups were randomly assigned to 4 groups (n=6 per group) using a random number table: normal
MS
MS with acupuncture stimulation at Shenmen (HT 7) acupoint (MS+HT 7)
and MS with acupuncture stimulation at Chengshan (BL 57) acupoint (MS+BL 57) groups. Rat pups in the normal group were housed with their mothers under standard conditions; those in the MS
MS+HT 7 and MS+BL 57 groups were maternally separated and individually maintained. Acupuncture stimulation was performed at HT 7 or BL 57 acupoints once a day for 7 consecutive days. A tail suspension test was performed to measure immobility time of rats and the plasma was collected on postnatal day 21
then levels of corticosterone (CORT)
interleukin (IL)-1β
IL-6 and glial cell-derived neurotrophic factor (GDNF) in plasma were measured. Compared with the normal group
the immobility time and the plasma levels of CORT
IL-1β
IL-6 and GDNF in the MS group were significantly increased (P<0.05 or P<0.01). Compared with the MS group
the immobility time and the plasma levels of CORT
IL-1β
IL-6 and GDNF were significantly reduced in the MS+HT 7 group (P<0.05 or P<0.01). Moreover
the immobility time and plasma levels of IL-1β and IL-6 in the MS+HT 7 group were significantly lower than those in the MS+BL 57 group (P<0.05). Acupuncture stimulation at HT 7 can alleviate the behavioral impairment and changes of the cytokines by MS
indicating that acupuncture can help to relieve MS-induced depression.
关键词
acupuncturedepressionmaternal separationcytokineinterleukin-1βinterleukin-6Corticosteroneglial cell-derived neurotrophic factor
Keywords
acupuncturedepressionmaternal separationcytokineinterleukin-1βinterleukin-6Corticosteroneglial cell-derived neurotrophic factor
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