Is acupuncture actually not effective for polycystic ovary syndrome?

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Is acupuncture actually not effective for polycystic ovary syndrome?

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- Is acupuncture actually not effective for polycystic ovary syndrome?
- Is acupuncture actually not effective for polycystic ovary syndrome?
- 中国结合医学杂志（英文版） 2017年23卷第12期页码：883-886
- Affiliations：
  
  Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-017-2831-z
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2017-12-13，
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Gang, Wj., Jing, Xh. Is acupuncture actually not effective for polycystic ovary syndrome?., Chin. J. Integr. Med. 23, 883–886 (2017). https://doi.org/10.1007/s11655-017-2831-z

Wei-juan Gang, Xiang-hong Jing. Is acupuncture actually not effective for polycystic ovary syndrome?[J]. Chinese Journal of Integrative Medicine, 2017,23(12):883-886.
Gang, Wj., Jing, Xh. Is acupuncture actually not effective for polycystic ovary syndrome?., Chin. J. Integr. Med. 23, 883–886 (2017). https://doi.org/10.1007/s11655-017-2831-z DOI：

Wei-juan Gang, Xiang-hong Jing. Is acupuncture actually not effective for polycystic ovary syndrome?[J]. Chinese Journal of Integrative Medicine, 2017,23(12):883-886. DOI： 10.1007/s11655-017-2831-z.

摘要

In recent years

acupuncture has been applied to treat more and more patients suffering from polycystic ovary syndrome (PCOS). On June 27

2017 a paper titled “Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome: a randomized clinical trial” was published in Journal of the American Medical Association (JAMA). The results did not support acupuncture as an effective therapy for improving the live births in PCOS. The aim of this article was to analyze the therapeutic regimen and design of the clinical trial. The primary outcome and the conclusion of the paper were discussed as well. There are 5 doubts in the paper. (1) The therapeutic regimen decided by trigger points in the paper was different from that of the traditional Chinese acupuncture. (2) The live birth as the primary outcome was limited during the PCOS recovery. (3) In addition the period of the treatment was too short to reflect the therapeutic effect. (4) Although there was no significant difference between active acupuncture and control acupuncture

the conclusion that acupuncture was not effective for PCOS was not confirmed because the control acupuncture plus clomiphene was also more effective than that of clomiphene alone. (5) The proposal and the statistics were not in accordance with the one planned before. Therefore the result was worth to be discussed so as to provide some suggestions and references for improving the clinical research of acupuncture.

Abstract

In recent years

acupuncture has been applied to treat more and more patients suffering from polycystic ovary syndrome (PCOS). On June 27

2017 a paper titled “Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome: a randomized clinical trial” was published in Journal of the American Medical Association (JAMA). The results did not support acupuncture as an effective therapy for improving the live births in PCOS. The aim of this article was to analyze the therapeutic regimen and design of the clinical trial. The primary outcome and the conclusion of the paper were discussed as well. There are 5 doubts in the paper. (1) The therapeutic regimen decided by trigger points in the paper was different from that of the traditional Chinese acupuncture. (2) The live birth as the primary outcome was limited during the PCOS recovery. (3) In addition the period of the treatment was too short to reflect the therapeutic effect. (4) Although there was no significant difference between active acupuncture and control acupuncture

the conclusion that acupuncture was not effective for PCOS was not confirmed because the control acupuncture plus clomiphene was also more effective than that of clomiphene alone. (5) The proposal and the statistics were not in accordance with the one planned before. Therefore the result was worth to be discussed so as to provide some suggestions and references for improving the clinical research of acupuncture.

关键词

acupuncture therapypolycystic ovary syndromeclinical trialregimen

Keywords

acupuncture therapypolycystic ovary syndromeclinical trialregimen

references

Wu XK, Stener-victorin E, Kuang HY, Ma HL, Gao JS, Xie LZ, et al. Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome: a randomized clinical trial. JAMA 2017;317:2502–2514.

Chen BY, Yu J. Relationship between blood radioimmunoreactive beta-endorphin and hand skin temperature during the electro-acupuncture induction of ovulation. Acupunct Electrother Res 1991;16:1–5.

Johansson J, Redman L, Veldhuis PP, Sazonova A, Labrie F, Holm G, et al. Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial. Am J Physiol Endocrinol Metab 2013;304:e934-E943.

Jedel E, Labrie F, Odén A, Holm G, Nilsson L, Janson PO, et al. Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial. Am J Physiol Endocrinol Metab 2011;300:e37-E45.

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Kuang HY, Li Y, Wu XK, Hou L, Wu T, Liu J, et al. Acupuncture and clomiphene citrate for live birth in polycystic ovary syndrome: study design of a randomized controlled trial. Evid Based Complement Alternat Med 2013;2013:527303.

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Shi Y, Feng HJ, Liu HR, Wu HG. Review on the pathogenesis and acupuncture treatment for polycystic ovarian syndrome. J Clin Acupunct Moxibust (Chin) 2008;24:55–58.

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Jin CL, Pang R, Xu LP, Wu ZC, Zhao JP. Clinical rules for acupoint selection and prescription composition in treatment of polycystic ovary syndrome with acupuncture. Chin Acupunct Moxibust (Chin) 2015;35:625–630.

Xie J, Li YW, Wen CB. Research on the acupoint law of acupuncture in the treatment of polycystic ovarian syndrome. Asia Pacif Tradit Med (Chin) 2016;12:89–91.

Pu JJ. Acupoints analysis by data mining polycystic ovary syndrome and its related symptom. Harbin: Heilongjiang University of Chinese Medicine;2012:24.

White A. Western medical acupuncture: a definition. Acupunct Med 2009;27:33–35.

Johansson J, Stener-Victorin E. Polycystic ovary syndrome: effect and mechanisms of acupuncture for ovulation induction. Evid Based Complement Alternat Med 2013;2013:762615.

Gong CZ, Liu W. To be, or not to be: the calculated politics of acupuncture in JAMA. Chin J Integr Med 2017;23:803–808.

Kuang HY, Zhang YH, Wu XK, Hou LH. Discussion on protocol design and implementation of effect on live birth rate of polycystic ovary syndrome treatment with acupuncture combined with clomiphene citrate. World Sci Technol Modern Tradit Chin Med (Chin) 2013;15:864–867.

Wu JN, Qin ZS, Liu ZS. Pivotal factors concerned in design of acupuncture clinical research: from two articles in JAMA. Chin J Integr Med 2017;23:809–811.

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Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, et al. Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2013;98:4565–4592.

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Beijing University of Chinese Medicine

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Department of Law, School of Humanities, Inner Mongolia University of Technology

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