Effects of Qishen Yiqi Dripping Pills (芪参益气滴丸) in Reducing Myocardial Injury and Preserving Microvascular Function in Patients Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study

Gui-xin He; Jun Xie; Hao Jiang; Wei Tan; Biao Xu

doi:10.1007/s11655-017-2955-1

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Effects of Qishen Yiqi Dripping Pills (芪参益气滴丸) in Reducing Myocardial Injury and Preserving Microvascular Function in Patients Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study

OriginalPaper | Updated：2021-08-27

- Effects of Qishen Yiqi Dripping Pills (芪参益气滴丸) in Reducing Myocardial Injury and Preserving Microvascular Function in Patients Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study
- Effects of Qishen Yiqi Dripping Pills (芪参益气滴丸) in Reducing Myocardial Injury and Preserving Microvascular Function in Patients Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study
- 中国结合医学杂志（英文版） 2018年24卷第3期页码：193-199
- Affiliations：
  
  1. Department of Cardiology, Drum Tower Hospital, Medical School of Nanjing University,Nanjing,China
  2. Department of Cardiology, the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-017-2955-1
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2017-5-3，
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He, Gx., Xie, J., Jiang, H. et al. Effects of Qishen Yiqi Dripping Pills (芪参益气滴丸) in Reducing Myocardial Injury and Preserving Microvascular Function in Patients Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study., Chin. J. Integr. Med. 24, 193–199 (2018). https://doi.org/10.1007/s11655-017-2955-1

Gui-xin He, Jun Xie, Hao Jiang, et al. Effects of Qishen Yiqi Dripping Pills (芪参益气滴丸) in Reducing Myocardial Injury and Preserving Microvascular Function in Patients Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study[J]. Chinese Journal of Integrative Medicine, 2018,24(3):193-199.
He, Gx., Xie, J., Jiang, H. et al. Effects of Qishen Yiqi Dripping Pills (芪参益气滴丸) in Reducing Myocardial Injury and Preserving Microvascular Function in Patients Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study., Chin. J. Integr. Med. 24, 193–199 (2018). https://doi.org/10.1007/s11655-017-2955-1 DOI：

Gui-xin He, Jun Xie, Hao Jiang, et al. Effects of Qishen Yiqi Dripping Pills (芪参益气滴丸) in Reducing Myocardial Injury and Preserving Microvascular Function in Patients Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study[J]. Chinese Journal of Integrative Medicine, 2018,24(3):193-199. DOI： 10.1007/s11655-017-2955-1.

摘要

To evaluate the effect of treatment with Qishen Yiqi Dripping Pills (芪参益气滴丸

QSYQ) on myocardial injury and myocardial microvascular function in patients undergoing elective percutaneous coronary intervention (PCI). Eighty patients undergoing elective PCI were randomly assigned to QSYQ and control groups. The QSYQ group received QSYQ at a dosage of 0.5 g 3 times daily (3–7 days before PCI and then daily for 1 month) and regular medication

which comprised of aspirin

clopidogrel

statin

β-blocker

and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker in the absence of contradiction. The control group received only the regular medication. The index of microcirculatory resistance (IMR) was measured at maximal hyperemia after PCI. The fractional flow reserve was measured before and after the procedure. Troponin I levels were obtained at baseline and 20–24 h after the procedure. Pre-PCI troponin I levels between the two groups were similar (0.028±0.05 vs. 0.022±0.04 ng/mL

P=0.55). However

post- PCI troponin I levels in the QSYQ group were significantly lower than that in the control group (0.11±0.02 vs. 0.16±0.09 ng/mL

P<0.01). IMR values were significantly lower in the QSYQ group as compared to the control group (16.5±6.1 vs. 31.2±16.0

P<0.01). Multivariate analysis identified QSYQ treatment as the only independent protective factor against IMR >32 (odds ratio=0.29

95% confidence interval: 0.11–0.74

P=0.01). The present study demonstrated the benefit of QSYQ in reducing myocardial injury and preserving microvascular function during elective PCI.

Abstract

To evaluate the effect of treatment with Qishen Yiqi Dripping Pills (芪参益气滴丸

which comprised of aspirin

clopidogrel

statin

β-blocker

P=0.55). However

post- PCI troponin I levels in the QSYQ group were significantly lower than that in the control group (0.11±0.02 vs. 0.16±0.09 ng/mL

P<0.01). IMR values were significantly lower in the QSYQ group as compared to the control group (16.5±6.1 vs. 31.2±16.0

P<0.01). Multivariate analysis identified QSYQ treatment as the only independent protective factor against IMR >32 (odds ratio=0.29

95% confidence interval: 0.11–0.74

P=0.01). The present study demonstrated the benefit of QSYQ in reducing myocardial injury and preserving microvascular function during elective PCI.

关键词

Myocardial Injurymicrovascular impairmentPercutaneous Coronary InterventionChinese Medicineherbs

Keywords

Myocardial Injurymicrovascular impairmentPercutaneous Coronary InterventionChinese Medicineherbs

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