Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial

Shi-wei LIU; Jie GUO; Wei-kang WU; Ze-liang CHEN; Ning ZHANG

doi:10.1007/s11655-017-2960-4

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Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial

Original Article | Updated：2021-08-27

- Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial
- Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial
- Chinese Journal of Integrative Medicine 2019年25卷第1期页码：16-22
- Affiliations：
  
  1.Department of Nephrology and Endocrinology, Wangjing Hospital, Chinese Academy of Chinese Medical Science, Beijing (100102), China
  2.Institute of Integrative Medicine, Sun Yat-sen University, Guangzhou (510275), China
  3.Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing (100071), China
  4.Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agriculture University, Shenyang (110866), China
- Author bio：
  
  Correspondence to: Prof. ZHANG Ning, Tel: 86-10-84739030, Fax: 86-10-84739030, E-mail: znice3927@sohu.com
- Funds：
  
  Chinese Academy of Traditional Chinese Medicine Joint Innovation Research Project(ZZ070808);Traditional Chinese Medicine Dominant Disease Clinical Research Project(CACMS08Y0016);Capital Featured Clinical Application and Promotion Project, China(Z151100004015132)
- DOI：10.1007/s11655-017-2960-4
  中图分类号：
- 纸质出版日期：2019-01-01，
  
  网络出版日期：2017-07-25，
  
  录用日期：2017-02-22
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Shi-wei LIU, Jie GUO, Wei-kang WU, 等. Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2019,25(1):16-22.

Shi-wei LIU, Jie GUO, Wei-kang WU, et al. Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2019,25(1):16-22.
Shi-wei LIU, Jie GUO, Wei-kang WU, 等. Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2019,25(1):16-22. DOI： 10.1007/s11655-017-2960-4.

Shi-wei LIU, Jie GUO, Wei-kang WU, et al. Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2019,25(1):16-22. DOI： 10.1007/s11655-017-2960-4.

摘要

Abstract

Objective:

To evaluate Chinese medicine (CM) formula Bazheng Powder (八正散) as an alternative therapeutic option for female patients with recurrent urinary tract infection (RUTI).

Methods:

A randomized double-blinded trial was performed. Eligible female patients with RUTI were recruited from one hospital and two community health centers. By using a blocked randomization scheme

participants were randomized to receive a CM formula (10 herbs) and antibiotics placebo for 4 weeks

or antibiotics for 1 week followed by 3 weeks of placebo and CM formula placebo. Clinical cure rate and microbiological cure and recurrence after treatment were evaluated.

Results:

A total 122 eligible patients were enrolled

with 61 cases in each group. The clinical cure rate by the intent-to-treatment approach was 90.2% for the CM group and 82.0% for the antibiotics group (

0.05). Bacteria were cleared from 88.5% (54/61) of patients in the CM group and 82.0% (50/61) in the antibiotics group. The recurrence rate in recovered patients at the 6-month follow-up was 9.1% (5/61) and 14.0 (7/61) in the CM and antibiotics groups

respectively (

0.05).

Conclusion:

CM formula Bazheng Powder is a good alternative option for RUTI treatment. (Registration No. NCT01745328)

关键词

Keywords

Chinese medicinerecurrent urinary tract infectionrandomized control trial

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