Effect of Jiaotai Pill (交泰丸) on intestinal damage in partially sleep deprived rats

Wen-ya Huang; Xin Zou; Fu-er Lu; Chu Zhang; Yan-lin Ren; Li-jun Xu; Kai-fu Wang; Hui Dong

doi:10.1007/s11655-017-2969-8

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Effect of Jiaotai Pill (交泰丸) on intestinal damage in partially sleep deprived rats

OriginalPaper | Updated：2021-08-27

- Effect of Jiaotai Pill (交泰丸) on intestinal damage in partially sleep deprived rats
- Effect of Jiaotai Pill (交泰丸) on intestinal damage in partially sleep deprived rats
- 中国结合医学杂志（英文版） 2017年23卷第12期页码：901-907
- Affiliations：
  
  Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81373871, 81473637)
- DOI：10.1007/s11655-017-2969-8
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2017-10-6，
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Huang, Wy., Zou, X., Lu, Fe. et al. Effect of Jiaotai Pill (交泰丸) on intestinal damage in partially sleep deprived rats., Chin. J. Integr. Med. 23, 901–907 (2017). https://doi.org/10.1007/s11655-017-2969-8

Wen-ya Huang, Xin Zou, Fu-er Lu, et al. Effect of Jiaotai Pill (交泰丸) on intestinal damage in partially sleep deprived rats[J]. Chinese Journal of Integrative Medicine, 2017,23(12):901-907.
Huang, Wy., Zou, X., Lu, Fe. et al. Effect of Jiaotai Pill (交泰丸) on intestinal damage in partially sleep deprived rats., Chin. J. Integr. Med. 23, 901–907 (2017). https://doi.org/10.1007/s11655-017-2969-8 DOI：

Wen-ya Huang, Xin Zou, Fu-er Lu, et al. Effect of Jiaotai Pill (交泰丸) on intestinal damage in partially sleep deprived rats[J]. Chinese Journal of Integrative Medicine, 2017,23(12):901-907. DOI： 10.1007/s11655-017-2969-8.

摘要

To explore the effect and mechanism of Jiaotai Pill (交泰丸

JTW) on intestinal mucosal damage in rats with chronic partial sleep deprivation (PSD). Obesity resistant (OR) rats were selected

and underwent 4 h PSD by being exposed to environmental noise for 4 weeks. During the whole PSD period

JTW and estazolam were orally given to the rats respectively in the treating groups. Plasma concentration of lipopolysaccharide (LPS) which is the marker of gut-origin endotoxemia was examined. Intestinal morphology changes were observed by optical microscopy. The protein expression of occludin (Ocln) in the intestine was measured by immunofluorescence technique and Western blot. The expressions of circadian proteins cryptochromes (Cry1 and Cry2) in the intestine were also determined. The treatment of JTW significantly decreased LPS level in OR rats with PSD (P<0.05). JTW also attenuated insomnia-induced intestinal injury like shorter

sparse and incomplete villus

wide gap between the villus

mucosal swelling and congesting (P<0.05). These changes were associated with the effect of JTW on up-regulating the expressions of Cry1 protein

Cry2 protein and Ocln protein in the intestine. JTW has the beneficial effect on improving intestinal mucosal damage caused by PSD. The mechanism appears to be related to the modulation of the expressions of circadian proteins and Ocln protein in the intestine

thereby attenuating inflammation and improving insulin resistance in insomnia rats.

Abstract

To explore the effect and mechanism of Jiaotai Pill (交泰丸

JTW) on intestinal mucosal damage in rats with chronic partial sleep deprivation (PSD). Obesity resistant (OR) rats were selected

and underwent 4 h PSD by being exposed to environmental noise for 4 weeks. During the whole PSD period

sparse and incomplete villus

wide gap between the villus

mucosal swelling and congesting (P<0.05). These changes were associated with the effect of JTW on up-regulating the expressions of Cry1 protein

thereby attenuating inflammation and improving insulin resistance in insomnia rats.

关键词

Chinese MedicineJiao-Tai-WanJiaotai Pillsleep deprivationintestinal damagelipopolysaccharideoccludincircadian clock

Keywords

Chinese MedicineJiao-Tai-WanJiaotai Pillsleep deprivationintestinal damagelipopolysaccharideoccludincircadian clock

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