Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Wei-ling Pu; Li-kang Sun; Xiu-mei Gao; Curzio Rüegg; Muriel Cuendet; Micheal O. Hottiger; Kun Zhou; Lin Miao; Yun-sha Zhang; Margaret Gebauer

doi:10.1007/s11655-017-2974-y

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Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

OriginalPaper | Updated：2021-08-27

- Targeting tumor-associated macrophages by anti-tumor Chinese materia medica
- Targeting tumor-associated macrophages by anti-tumor Chinese materia medica
- 中国结合医学杂志（英文版） 2017年23卷第10期页码：723-732
- Affiliations：
  
  1. Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine,Tianjin,China
  2. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine,Tianjin,China
  3. School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine,Tianjin,China
  4. Pathology Unit, Department of Medicine, Faculty of Sciences, University of Fribourg, Fribourg,Switzerland
  5. School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Genève,Switzerland
  6. Department of Molecular Mechanisms of Disease, University of Zurich-Irchel,Zurich,Switzerland
  7. Chingcura, Center for Traditional Chinese Medicine,Zurich,Switzerland
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81630106);Tianjin University of Traditional Chinese Medicine Foundation;Natural Science Foundation Tibetan Autonomous Region of China;Sino Swiss Science and Technology Cooperation programme (Nos. EG 03-032015, EG 05-032015, EG 07-032016)
- DOI：10.1007/s11655-017-2974-y
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2017-10-8，
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Pu, Wl., Sun, Lk., Gao, Xm. et al. Targeting tumor-associated macrophages by anti-tumor Chinese materia medica., Chin. J. Integr. Med. 23, 723–732 (2017). https://doi.org/10.1007/s11655-017-2974-y

Wei-ling Pu, Li-kang Sun, Xiu-mei Gao, et al. Targeting tumor-associated macrophages by anti-tumor Chinese materia medica[J]. Chinese Journal of Integrative Medicine, 2017,23(10):723-732.
Pu, Wl., Sun, Lk., Gao, Xm. et al. Targeting tumor-associated macrophages by anti-tumor Chinese materia medica., Chin. J. Integr. Med. 23, 723–732 (2017). https://doi.org/10.1007/s11655-017-2974-y DOI：

Wei-ling Pu, Li-kang Sun, Xiu-mei Gao, et al. Targeting tumor-associated macrophages by anti-tumor Chinese materia medica[J]. Chinese Journal of Integrative Medicine, 2017,23(10):723-732. DOI： 10.1007/s11655-017-2974-y.

摘要

Tumor-associated macrophages (TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines

chemokines

and enzymes to affect the progression

metastasis

and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment. Chinese materia medica (CMM) is an important approach for treating cancer in China and in the Asian region. According to the theory of Chinese medicine (CM) and its practice

some prescriptions of CM regulate the body's internal environment possibly including the remodeling the tumor microenvironment (TME). Here we briefly summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis

invasion

metastasis and immunosuppression. Furthermore

we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally

we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs

and hopefully

provide the theoretical basis for CMM clinical practice related to cancer therapy.

Abstract

Tumor-associated macrophages (TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines

chemokines

and enzymes to affect the progression

metastasis

invasion

metastasis and immunosuppression. Furthermore

we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally

we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs

and hopefully

provide the theoretical basis for CMM clinical practice related to cancer therapy.

关键词

tumor-associated macrophagestumor microenvironmentChinese Materia MedicaChinese Medicineanti-tumor therapy

Keywords

tumor-associated macrophagestumor microenvironmentChinese Materia MedicaChinese Medicineanti-tumor therapy

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