Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis
Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis
Chinese Journal of Integrative Medicine2019年25卷第5期 页码:370-377
Affiliations:
1.Orthopedic Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai (200032), China
2.Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai (200032), China
Author bio:
Correspondence to: Prof. YANG Yan-ping, Tel: 86-21-64286239, Fax: 86-21-64434704, E-mail: yanpingyangks@163.com
Funds:
the National Nature Science Foundation of China(8167400681603343,;81330085);the Program for Innovative Research Team of Ministry of Science and Technology of China(2015RA4002)
Jun-li CHANG, Wen-yi WANG, Yi-mian LI, 等. Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis[J]. Chinese Journal of Integrative Medicine, 2019,25(5):370-377.
Jun-li CHANG, Wen-yi WANG, Yi-mian LI, et al. Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis[J]. Chinese Journal of Integrative Medicine, 2019,25(5):370-377.
Jun-li CHANG, Wen-yi WANG, Yi-mian LI, 等. Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis[J]. Chinese Journal of Integrative Medicine, 2019,25(5):370-377. DOI: 10.1007/s11655-018-2565-6.
Jun-li CHANG, Wen-yi WANG, Yi-mian LI, et al. Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis[J]. Chinese Journal of Integrative Medicine, 2019,25(5):370-377. DOI: 10.1007/s11655-018-2565-6.
Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis
摘要
Abstract
Objective:
2
To summarize and critically assess the inhibitory effects of Chinese herbal medicine (CHM) on tumor volume and tumor weight for the treatment of osteosarcoma (OS) in mouse models.
Methods:
2
PubMed
Embase
Web of Science
China Knowledge Resource Integrated Database (CNKI)
Wanfang Database
VIP Database
and Chinese BioMedical (CBM) were searched since their inception dates to March 10
2016. Two reviewers independently selected the controlled studies estimating effects of CHM on mouse OS by administration
in vivo
. A pair-wise meta-analysis was performed. Twenty-five studies with adequate randomization were included in the systematic review.
Results:
2
CHM may significantly inhibit OS growth in mice
as assessed using the tumor weight [20 studies
n
=443; 290 for CHM and 153 for the control; pooled mean difference (MD)=–2.90; 95% confidence interval (CI): –3.50 to –2.31;
P
<
0.01]
tumor volume (16 studies
n
=382; 257 for CHM and 125 for the control; pooled MD =–2.57; 95% CI: –3.33 to –1.80;
P
<
0.01) and tumor growth inhibition rate.
Conclusion:
2
CHM could significantly inhibit the growth of OS in mouse models
which might be supportive for the design of preclinical and clinical trials in future.
关键词
Keywords
Chinese herbal medicineosteosarcomasystematic reviewmeta-analysismousexenograft model
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相关作者
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相关机构
Graduate School, School of Clinical Medicine, Tsinghua University
Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University
Shanxi Tumour Hospital
College of Preschool Education, Beijing Youth Politics College
School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine