Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma

Martha Perez Gutierrez Rosa; Maria Mota Flores Jose

doi:10.1007/s11655-018-2566-5

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Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma

OriginalPaper | Updated：2021-08-27

- Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma
- Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma
- 中国结合医学杂志（英文版） 2018年24卷第12期页码：912-919
- Affiliations：
  
  Natural Products Research Laboratory, Higher School of Chemical Engineering and Extractive Industries,Mexico City,Mexico
- Author bio：
- Funds：
- DOI：10.1007/s11655-018-2566-5
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2018-10-19，
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Rosa, M.P.G., Jose, M.M.F. Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma., Chin. J. Integr. Med. 24, 912–919 (2018). https://doi.org/10.1007/s11655-018-2566-5

Martha Perez Gutierrez Rosa, Maria Mota Flores Jose. Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma[J]. Chinese Journal of Integrative Medicine, 2018,24(12):912-919.
Rosa, M.P.G., Jose, M.M.F. Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma., Chin. J. Integr. Med. 24, 912–919 (2018). https://doi.org/10.1007/s11655-018-2566-5 DOI：

Martha Perez Gutierrez Rosa, Maria Mota Flores Jose. Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma[J]. Chinese Journal of Integrative Medicine, 2018,24(12):912-919. DOI： 10.1007/s11655-018-2566-5.

摘要

To examine the effect of metanol extract of Petiveria alliacea (PM) on airway inflflammation in a murine model of chronic asthma. Two-month-old male BALB/c mice (n=6–8/group) were sensitized on days 0 and 14 by intraperitoneal injection of 20 μg ovalbumin (OVA). On day 25

the mice received an airway challenge with OVA (3%

w/v

in phosphate buffered saline). PM was administered orally by oral gavage to mice at doses of 100

200 and 400 mg/kg body weight once daily from days 18 to 23. Control mice were orally administered phosphate buffered saline (PBS) to induce a model of asthma. At the end of the test

respiratory reactivity was assayed

the total cell number

interleukin-4 (IL-4)

IL-5

IL-13

tumor necrosis factor-alpha (TNF-α) and reactive oxygen species (ROS) in the bronchoalveolar lavage fluid (BALF) were determined and the levels of serum IgE

intercellular cell adhesion molecule 1 (ICAM-1) and eotoxin were measured. In addition

lung tissue was used to qualify the IL-4

IL-5

IL-13

TNF-α and transforming growth factor beta 1 (TGF-β1). Histologic examination was performed to observe inflammatory cellular infiltration. The administration of PM in comparison with the OVA-only treated group signifificantly attenuated the infifiltration of eosinophils and other inflflammatory cells (P<0.01). Airway resistance (RI) in the OVA-only induced group was significantly higher than that of the PBS control group (P<0.01) when methacholine was added. TNF-α

IgE

TGF-β1 and cytokine levels IL-4

IL-5

IL-13 in the BALF decreased compared to control mice (P<0.01 or P<0.05). PM treatment also inhibited the production of chemokines

eotaxin and ICAM-1 in BALF (P<0.01)

which improved lung function. Histopathological examination revealed that the sensitized treated PM groups had significant lower in inflammatory scores similar to dexamethasone treatments and the untreated group. Administration of PM could inhibit airway inflammation

regulate cytokines

chemokines and enhance pulmonary conditions in allergic murine model of asthma.

Abstract

the mice received an airway challenge with OVA (3%

w/v

in phosphate buffered saline). PM was administered orally by oral gavage to mice at doses of 100

200 and 400 mg/kg body weight once daily from days 18 to 23. Control mice were orally administered phosphate buffered saline (PBS) to induce a model of asthma. At the end of the test

respiratory reactivity was assayed

the total cell number

interleukin-4 (IL-4)

IL-5

IL-13

tumor necrosis factor-alpha (TNF-α) and reactive oxygen species (ROS) in the bronchoalveolar lavage fluid (BALF) were determined and the levels of serum IgE

intercellular cell adhesion molecule 1 (ICAM-1) and eotoxin were measured. In addition

lung tissue was used to qualify the IL-4

IL-5

IL-13

IgE

TGF-β1 and cytokine levels IL-4

IL-5

IL-13 in the BALF decreased compared to control mice (P<0.01 or P<0.05). PM treatment also inhibited the production of chemokines

eotaxin and ICAM-1 in BALF (P<0.01)

regulate cytokines

chemokines and enhance pulmonary conditions in allergic murine model of asthma.

关键词

Petiveria alliaceaallergyantiinflflammationAsthma

Keywords

Petiveria alliaceaallergyantiinflflammationAsthma

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