Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*

Chi ZHANG; Li LI; Ge ZHANG; Ke-ji CHEN; Ai-ping LU

doi:10.1007/s11655-018-2571-8

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Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*

Academic Exploration | Updated：2021-09-01

- Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*
- Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*
- Chinese Journal of Integrative Medicine 2021年27卷第6期页码：465-469
- Affiliations：
  
  1.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing (100700), China
  2.Institute for Advancing Translational Medicine in Bone and Joint Diseases, Hong Kong Baptist University, Hong Kong SAR, China
  3.Cardiovascular Disease Centre, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
- Author bio：
  
  Prof. LU Ai-ping, E-mail: aipinglu@hkbu.edu.hk
- Funds：
  
  the National Natural Science Foundation of China(81503449;81673773)
- DOI：10.1007/s11655-018-2571-8
  中图分类号：
- 纸质出版日期：2021-06-01，
  
  网络出版日期：2018-10-19，
  
  录用日期：2017-01-09
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Chi ZHANG, Li LI, Ge ZHANG, 等. Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*[J]. Chinese Journal of Integrative Medicine, 2021,27(6):465-469.

Chi ZHANG, Li LI, Ge ZHANG, et al. Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*[J]. Chinese Journal of Integrative Medicine, 2021,27(6):465-469.
Chi ZHANG, Li LI, Ge ZHANG, 等. Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*[J]. Chinese Journal of Integrative Medicine, 2021,27(6):465-469. DOI： 10.1007/s11655-018-2571-8.

Chi ZHANG, Li LI, Ge ZHANG, et al. Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis*[J]. Chinese Journal of Integrative Medicine, 2021,27(6):465-469. DOI： 10.1007/s11655-018-2571-8.

摘要

Abstract

Biological complexity and the need for personalized medicine means that biomarker development has become increasingly challenging. Thus

new paradigms for research need to be created that bring together a different classifier of individuals. One potential solution is collaboration between biomarker development and Chinese medicine pattern classification. In this article

two examples of rheumatoid arthritis are discussed

including a new biomarker candidate casein kinase 2 interacting protein 1 (CKIP-1) and a micro RNA 214. The authors obtained a "snapshot" of pattern classification with disease in biomarker identification. Bioinformatics analyses revealed underlying biological functions of two biomarker candidates

in varying degrees

are correlated with Chinese medicine pattern of rheumatoid arthritis. The authors' initial attempt can provide a new window for studying the win-win potential correlation between the biomarkers and pattern classification in Chinese medicine.

关键词

Keywords

Chinese medicine pattern classificationbiomarkerrheumatoid arthritis

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