Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine

Qian ZHANG; Xiao-chun LIANG

doi:10.1007/s11655-018-2579-0

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Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine

Review | Updated：2021-08-27

- Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine
- Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine
- Chinese Journal of Integrative Medicine 2019年25卷第5期页码：386-394
- Affiliations：
  
  Department of Traditional Chinese Medicine, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing (100730), China
- Author bio：
  
  Correspondence to: Prof. LIANG Xiao-chun, Tel: 86-10-69155331, E-mail: xcliang@vip.sina.com
- Funds：
  
  the National Natural Science Foundation of China(81473639);the Fundamental Research Funds for the Central Universities(3332018037)
- DOI：10.1007/s11655-018-2579-0
  中图分类号：
- 纸质出版日期：2019-05-01，
  
  网络出版日期：2019-01-09，
  
  录用日期：2018-05-14
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Qian ZHANG, Xiao-chun LIANG. Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine[J]. Chinese Journal of Integrative Medicine, 2019,25(5):386-394.

Qian ZHANG, Xiao-chun LIANG. Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine[J]. Chinese Journal of Integrative Medicine, 2019,25(5):386-394.
Qian ZHANG, Xiao-chun LIANG. Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine[J]. Chinese Journal of Integrative Medicine, 2019,25(5):386-394. DOI： 10.1007/s11655-018-2579-0.

Qian ZHANG, Xiao-chun LIANG. Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine[J]. Chinese Journal of Integrative Medicine, 2019,25(5):386-394. DOI： 10.1007/s11655-018-2579-0.

摘要

Abstract

Diabetic peripheral neuropathy (DPN) is a progressive neurodegenerative disease of peripheral nervous system with high energy requirement. The adenosine monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) axis plays a key role in regulating mitochondrial energy metabolism. Increasing preclinical evidences have shown that inhibition of AMPK/PGC-1α pathway leading to mitochondrial dysfunction in neurons or Schwann cells contributes to neuron apoptosis

distal axonopathy and nerve demyelination in DPN. Some Chinese medicine formulae or extracts from herbs may have potential neuroprotective effects on DPN via activating AMPK/PGC-1α pathway and improving mitochondrial function.

关键词

Keywords

monophosphate-activated protein kinaseperoxisome proliferator-activated receptor-γ coactivator 1αsirtuinsdiabetic peripheral neuropathyChinese medicine

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