Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial

Ji-meng Zhao; Jin-hua Lu; Xiao-jun Yin; Lu-yi Wu; Chun-hui Bao; Xing-kui Chen; Yue-hua Chen; Wei-jun Tang; Xiao-ming Jin; Huan-gan Wu; Yin Shi

doi:10.1007/s11655-018-2838-0

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Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial

OriginalPaper | Updated：2021-08-27

- Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial
- Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial
- 中国结合医学杂志（英文版） 2018年24卷第5期页码：328-335
- Affiliations：
  
  1. Shanghai Research Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine,Shanghai,China
  2. Medical Imaging Department, Jinhua Municipal Central Hospital,Jinhua,China
  3. Department of Acupuncture and Moxibustion, Jinhua Municipal Central Hospital,Jinhua,China
  4. Department of Digestive System, Jinhua Municipal Central Hospital,Jinhua,China
  5. Radiology Department, Huashan Hospital, Fudan University,Shanghai,China
  6. Department of Anatomy and Cell Biology, Indiana University School of Medicine,Indianapolis,USA
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30973784) and the National Basic Research Program of China, 973 program (No. 2009CB522900)
- DOI：10.1007/s11655-018-2838-0
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2018-5-11，
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Zhao, Jm., Lu, Jh., Yin, Xj. et al. Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial., Chin. J. Integr. Med. 24, 328–335 (2018). https://doi.org/10.1007/s11655-018-2838-0

Ji-meng Zhao, Jin-hua Lu, Xiao-jun Yin, et al. Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2018,24(5):328-335.
Zhao, Jm., Lu, Jh., Yin, Xj. et al. Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial., Chin. J. Integr. Med. 24, 328–335 (2018). https://doi.org/10.1007/s11655-018-2838-0 DOI：

Ji-meng Zhao, Jin-hua Lu, Xiao-jun Yin, et al. Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2018,24(5):328-335. DOI： 10.1007/s11655-018-2838-0.

摘要

To compare the effects of electroacupuncture (EA) and mild-warm moxibustion (Mox) therapies for constipation-predominant irritable bowel syndrome (C-IBS) patients. Sixty C-IBS patients were assigned to 2 groups by simple randomized method

i.e. EA group (30 cases) and Mox group (30 cases). Both EA and Mox treatments were performed on bilateral Tianshu (ST 25) and Shangjuxu (ST 37) for 30 min each time

6 times per week

for 4 consecutive weeks. The gastrointestinal symptoms and psychological symptoms of the two groups were scored before and after treatment. The effects on the corresponding functional brain areas

namely the anterior cingulate cortex (ACC)

insular cortex (IC) and prefrontal cortex (PFC) were observed by functional magnetic resonance imaging (fMRI) before and after treatment. Compared with the Mox group

greater improvements in abdominal distension

defecation frequency

diffificulty in defecation and stool features were observed in the EA group (all P<0.01)

both Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores were signifificantly decreased in the EA group (all P<0.01). Finally

decreased activated voxel values were observed in the ACC

right IC and PFC brain regions of EA group with 150 mL colorectal distension stimulation (P<0.05 or P<0.01). Both EA and Mox could signifificantly improve some of the most intrusive symptoms of C-IBS patients

and EA was more effective than Mox. The therapeutic effect of these two therapies might through modulating of the brain-gut axis function. (Registration No. ChiCTRTRC-11001349).

Abstract

i.e. EA group (30 cases) and Mox group (30 cases). Both EA and Mox treatments were performed on bilateral Tianshu (ST 25) and Shangjuxu (ST 37) for 30 min each time

6 times per week

for 4 consecutive weeks. The gastrointestinal symptoms and psychological symptoms of the two groups were scored before and after treatment. The effects on the corresponding functional brain areas

namely the anterior cingulate cortex (ACC)

insular cortex (IC) and prefrontal cortex (PFC) were observed by functional magnetic resonance imaging (fMRI) before and after treatment. Compared with the Mox group

greater improvements in abdominal distension

defecation frequency

diffificulty in defecation and stool features were observed in the EA group (all P<0.01)

both Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores were signifificantly decreased in the EA group (all P<0.01). Finally

decreased activated voxel values were observed in the ACC

and EA was more effective than Mox. The therapeutic effect of these two therapies might through modulating of the brain-gut axis function. (Registration No. ChiCTRTRC-11001349).

关键词

Irritable Bowel SyndromeConstipationelectroacupuncturemoxibustionrandomized controlled trial

Keywords

Irritable Bowel SyndromeConstipationelectroacupuncturemoxibustionrandomized controlled trial

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