Essence of “Shen (Kidney) Controlling Bones”: Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis

Tao-tao Xu; Hong-ting Jin; Pei-jian Tong

doi:10.1007/s11655-018-2930-x

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Essence of “Shen (Kidney) Controlling Bones”: Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis

OriginalPaper | Updated：2021-08-27

- Essence of “Shen (Kidney) Controlling Bones”: Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis
- Essence of “Shen (Kidney) Controlling Bones”: Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis
- 中国结合医学杂志（英文版） 2018年24卷第11期页码：806-808
- Affiliations：
  
  1. First Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou,China
  2. Institute of Orthopaedics and Traumatology, First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,China
  3. Department of Orthopaedics, First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,China
- Author bio：
- Funds：
  
  Supported by the Major Science and Technology Special Project of Zhejiang Province to TONG Pei-jian (No. 2014C03035), the Zhejiang Provincial Major Science and Technology Project of Medical and Health of China to TONG Pei-jian (No. 201487674), and Cultivation Program for Innovative Talent Graduate Students to XU Tao-tao (No. 311100G00901) from Zhejiang Chinese Medical University
- DOI：10.1007/s11655-018-2930-x
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2018-4-12，
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Xu, Tt., Jin, Ht. & Tong, Pj. Essence of “Shen (Kidney) Controlling Bones”: Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis., Chin. J. Integr. Med. 24, 806–808 (2018). https://doi.org/10.1007/s11655-018-2930-x

Tao-tao Xu, Hong-ting Jin, Pei-jian Tong. Essence of “Shen (Kidney) Controlling Bones”: Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis[J]. Chinese Journal of Integrative Medicine, 2018,24(11):806-808.
Xu, Tt., Jin, Ht. & Tong, Pj. Essence of “Shen (Kidney) Controlling Bones”: Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis., Chin. J. Integr. Med. 24, 806–808 (2018). https://doi.org/10.1007/s11655-018-2930-x DOI：

Tao-tao Xu, Hong-ting Jin, Pei-jian Tong. Essence of “Shen (Kidney) Controlling Bones”: Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis[J]. Chinese Journal of Integrative Medicine, 2018,24(11):806-808. DOI： 10.1007/s11655-018-2930-x.

摘要

As a traditional concept of Chinese medicine (CM)

the theory of “Shen (Kidney) controlling bones” has been gradually proven. And in modern allopathic medicine

the multiple mechanisms of bone growth

development and regeneration align with the theory. Shen deficiency as a pathological condition has a negative effect on the skeleton of body

specifically the disorder of bone homeostasis. Present studies indicate that Shen deficiency shares a common disorder characterized by dysfunction of hypothalamic-pituitary-adrenal (HPA) axis. HPA axis may be an important regulator of bone diseases with abnormal homeostasis. Therefore

we posit the existence of hypothalamic-pituitary-adrenal-osteo-related cells axis: cells that comprise bone tissue (osteo-related cells) are targets under the regulation of HPA axis in disorder of bone homeostasis. Chinese herbs for nourishing Shen have potential in the development of treatments for disorder of bone homeostasis.

Abstract

As a traditional concept of Chinese medicine (CM)

the theory of “Shen (Kidney) controlling bones” has been gradually proven. And in modern allopathic medicine

the multiple mechanisms of bone growth

development and regeneration align with the theory. Shen deficiency as a pathological condition has a negative effect on the skeleton of body

关键词

Chinese MedicineShen (Kidney) controlling boneshypothalamic-pituitary-adrenal axisbone homeostasisOsteoporosis

Keywords

Chinese MedicineShen (Kidney) controlling boneshypothalamic-pituitary-adrenal axisbone homeostasisOsteoporosis

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