Shexiang Tongxin Dropping Pill (麝香通心滴丸) Protects against Na2S2O4-Induced Hypoxia-Reoxygenation Injury in H9c2 Cells

Shan LIN; Jiu-mao LIN; Ling ZHANG; Da-xin CHEN; Fei XIAO; Hong-wei CHEN; You-qin CHEN; Yu-ling ZHU; Jian-feng CHU; Jun PENG

doi:10.1007/s11655-018-2976-4

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Shexiang Tongxin Dropping Pill (麝香通心滴丸) Protects against Na₂S₂O₄-Induced Hypoxia-Reoxygenation Injury in H9c2 Cells

Original Article | Updated：2021-08-27

- Shexiang Tongxin Dropping Pill (麝香通心滴丸) Protects against Na₂S₂O₄-Induced Hypoxia-Reoxygenation Injury in H9c2 Cells
- Shexiang Tongxin Dropping Pill (麝香通心滴丸) Protects against Na₂S₂O₄-Induced Hypoxia-Reoxygenation Injury in H9c2 Cells
- Chinese Journal of Integrative Medicine 2019年25卷第6期页码：439-445
- Affiliations：
  
  1.Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou (350122), China
  2.Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou (350122), China
  3.Rainbow Babies Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH (44106), USA
  4.Inner Mongolia Conba Pharmaceutical Co., Ltd., Shanghai (201318), China
  5.CHEN Ke-ji Academic Thought Heritage Studio, Fuzhou (350122), China
- Author bio：
  
  Correspondence to: Prof. PENG Jun, Tel: 86-591-22861303, E-mail: pjunlab@hotmail.com
- Funds：
  
  the Foundation of Fujian University of Traditional Chinese Medicine(X2013026);the Developmental Fund of Chen Ke-ji Integrative Medicine(CKJ2013016);the Education Department of Fujian Province(JA14163)
- DOI：10.1007/s11655-018-2976-4
  中图分类号：
- 纸质出版日期：2019-06-01，
  
  网络出版日期：2018-04-04，
  
  录用日期：2017-07-14
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Shan LIN, Jiu-mao LIN, Ling ZHANG, 等. Shexiang Tongxin Dropping Pill (麝香通心滴丸) Protects against Na₂S₂O₄-Induced Hypoxia-Reoxygenation Injury in H9c2 Cells[J]. Chinese Journal of Integrative Medicine, 2019,25(6):439-445.

Shan LIN, Jiu-mao LIN, Ling ZHANG, et al. Shexiang Tongxin Dropping Pill (麝香通心滴丸) Protects against Na₂S₂O₄-Induced Hypoxia-Reoxygenation Injury in H9c2 Cells[J]. Chinese Journal of Integrative Medicine, 2019,25(6):439-445.
Shan LIN, Jiu-mao LIN, Ling ZHANG, 等. Shexiang Tongxin Dropping Pill (麝香通心滴丸) Protects against Na₂S₂O₄-Induced Hypoxia-Reoxygenation Injury in H9c2 Cells[J]. Chinese Journal of Integrative Medicine, 2019,25(6):439-445. DOI： 10.1007/s11655-018-2976-4.

Shan LIN, Jiu-mao LIN, Ling ZHANG, et al. Shexiang Tongxin Dropping Pill (麝香通心滴丸) Protects against Na₂S₂O₄-Induced Hypoxia-Reoxygenation Injury in H9c2 Cells[J]. Chinese Journal of Integrative Medicine, 2019,25(6):439-445. DOI： 10.1007/s11655-018-2976-4.

摘要

Abstract

Objectives:

To investigate the protective effects of Shexiang Tongxin Dropping Pill (麝香通心滴丸

STP) on Na

-induced hypoxia-reoxygenation injury in cardiomyoblast H9c2 cells.

Methods:

The cell viability and levels of mRNA and protein expression in H9c2 cells were determined following Na

-induced hypoxia using Hoechst staining

annexin V/propidium iodide (PI) flow cytometry

real-time polymerase chain reaction and Western blot analysis.

Results:

STP pretreatment significantly increased the viability and inhibited aberrant morphological changes in H9c2 cardiomyoblast cells induced by Na

treatment (

0.05). In addition

STP pretreatment attenuated Na

-induced hypoxic damage

down-regulated the expression of pro-apoptotic Bax

and up-regulated the expression of anti-apoptotic Bcl-2 in H9c2 cells (

0.05).

Conclusions:

STP was strongly cardioprotective in hypoxia-reoxygenation injury by preventing hypoxic damage and inhibiting cellular apoptosis. These results further support the use of STP as an effective drug for the treatment of ischemic heart disease.

关键词

Keywords

myocardial ischemiaapoptosisShexiang Tongxin Dropping PillChinese medicineNa2S2O4-induced hypoxia-reoxygenation injury

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