Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder (复方青黄散) in Patients with Myelodysplastic Syndromes

Pan ZHAO; Jun-bin LIANG; Zhong-yang DENG; Ming-jing WANG; Jia-yue QIN; Chong-jian CHEN; Xiao-mei HU

doi:10.1007/s11655-018-2977-3

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Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder (复方青黄散) in Patients with Myelodysplastic Syndromes

Original Article | Updated：2021-08-27

- Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder (复方青黄散) in Patients with Myelodysplastic Syndromes
- Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder (复方青黄散) in Patients with Myelodysplastic Syndromes
- Chinese Journal of Integrative Medicine 2019年25卷第6期页码：409-415
- Affiliations：
  
  1.Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
  2.Annoroad Gene Technology Co. Ltd., Beijing (100176), China
- Author bio：
  
  CHEN Chong-jian, E-mail: cchen@annoroad.com
  Correspondence to: Prof. HU Xiao-mei, Tel: 86-10-62835627, E-mail: huxiaomei_2@163.com;
- Funds：
  
  the Beijing Municiple Science and Technology Commission(Z141100006014003);the National Natural Science Foundation of China(81673821);the Special Research Foundation of Central Level Public Scientific Research Institutes(ZZ10-016)
- DOI：10.1007/s11655-018-2977-3
  中图分类号：
- 纸质出版日期：2019-06-01，
  
  网络出版日期：2018-04-04，
  
  录用日期：2017-07-24
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Pan ZHAO, Jun-bin LIANG, Zhong-yang DENG, 等. Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder (复方青黄散) in Patients with Myelodysplastic Syndromes[J]. Chinese Journal of Integrative Medicine, 2019,25(6):409-415.

Pan ZHAO, Jun-bin LIANG, Zhong-yang DENG, et al. Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder (复方青黄散) in Patients with Myelodysplastic Syndromes[J]. Chinese Journal of Integrative Medicine, 2019,25(6):409-415.
Pan ZHAO, Jun-bin LIANG, Zhong-yang DENG, 等. Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder (复方青黄散) in Patients with Myelodysplastic Syndromes[J]. Chinese Journal of Integrative Medicine, 2019,25(6):409-415. DOI： 10.1007/s11655-018-2977-3.

Pan ZHAO, Jun-bin LIANG, Zhong-yang DENG, et al. Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder (复方青黄散) in Patients with Myelodysplastic Syndromes[J]. Chinese Journal of Integrative Medicine, 2019,25(6):409-415. DOI： 10.1007/s11655-018-2977-3.

摘要

Abstract

Objective:

To investigate the relationship between gene mutations and response to Compound Qinghuang Powder (复方青黄散

CQHP) in patients with myelodysplastic syndrome (MDS).

Methods:

Forty-three MDS patients after treatment with CQHP for 6 months were genotyped by ultra-deep targeted sequencing and the clinical data of patients were collected and the relationship between them was analyzed.

Results:

Up to 41.86% of patients harbored genet mutations

in most cases with more than one mutation. The most common mutations were in SF3B1

U2AF1

ASXL1

and DNMT3A. After treatment with CQHP

about 88.00% of patients no longer required blood transfusion

or needed half of prior transfusions.

Conlusion:

CQHP is an effective treatment for patients with MDS

especially those with gene mutations in SF3B1

DNMT3A

U2AF1

and/or ASXL1.

关键词

Keywords

myelodysplastic syndromesarsenicnext-generation sequencingrealgar

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