Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing

Shuai YAN; Yin-zi YUE; Yang ZONG; Li ZENG

doi:10.1007/s11655-018-3021-3

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Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing

Review | Updated：2021-08-27

- Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing
- Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing
- Chinese Journal of Integrative Medicine 2019年25卷第7期页码：554-560
- Affiliations：
  
  1.Department of Anorectal Surgery, Suzhou Hospital of Traditional Chinese Medicine, Suzhou (215009), Jiangsu Province, China
  2.First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing (210023), China
- Author bio：
  
  Correspondence to: Prof. ZENG Li, Tel: 86-25-85811788, E-mail: zengbingli@163.com
- Funds：
  
  the National Natural Science Foundation of China(81804098;81673982);Natural Science Foundation of Jiangsu Province(BK20180219);Young Talents in Jiangsu Province(QNRC2016255);Youth Project of Suzhou Traditional Chinese Medicine Hospital(YQN2016003)
- DOI：10.1007/s11655-018-3021-3
  中图分类号：
- 纸质出版日期：2019-07-01，
  
  网络出版日期：2019-01-09，
  
  录用日期：2018-05-03
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Shuai YAN, Yin-zi YUE, Yang ZONG, 等. Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing[J]. Chinese Journal of Integrative Medicine, 2019,25(7):554-560.

Shuai YAN, Yin-zi YUE, Yang ZONG, et al. Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing[J]. Chinese Journal of Integrative Medicine, 2019,25(7):554-560.
Shuai YAN, Yin-zi YUE, Yang ZONG, 等. Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing[J]. Chinese Journal of Integrative Medicine, 2019,25(7):554-560. DOI： 10.1007/s11655-018-3021-3.

Shuai YAN, Yin-zi YUE, Yang ZONG, et al. Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing[J]. Chinese Journal of Integrative Medicine, 2019,25(7):554-560. DOI： 10.1007/s11655-018-3021-3.

摘要

Abstract

Plants are known to possess plenty of pharmacological activities as a result of various phytoconstituents. Tetramethylpyrazine (TMP)

one of the most widely used medicinal compound isolated from traditional Chinese herb

is usually employed for anti-oxidation

anti-inflammation

anti-platelet aggregation

antilipid

anti-fibrosis

as well as activating blood

removing stasis

dilating small arteries

improving microcirculation and antagonizing calcium. In the present paper

the anti-adhesion effect of TMP were reviewed. TMP was found to play a multi-target and muti-link role in anti-adhesion by inhibiting hyperplasia of collagen and overexpression of adhesion-related factors and reducing the concentration of white blood cells and fibrin in plasma. Because previous studies mostly focused on

in vitro

experiments and animal experiments

there is an urgent need for clinical research with abundant indicators to further prove its anti-adhesion potency. Future basic research should concentrate on the development of TMP as a biological material.

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tetramethylpyrazinetissue adhesionpharmacological activityreview

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