Ursolic Acid Prevents Retinoic Acid-Induced Bone Loss in Rats

Min CHENG; Xu-hua LIANG; Qing-wei WANG; Ya-ting DENG; Zhi-xin ZHAO; Xue-ying LIU

doi:10.1007/s11655-018-3050-y

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Ursolic Acid Prevents Retinoic Acid-Induced Bone Loss in Rats

Original Article | Updated：2021-08-27

- Ursolic Acid Prevents Retinoic Acid-Induced Bone Loss in Rats
- Ursolic Acid Prevents Retinoic Acid-Induced Bone Loss in Rats
- Chinese Journal of Integrative Medicine 2019年25卷第3期页码：210-215
- Affiliations：
  
  1.College of Biology Pharmacy and Food Engineering, Shangluo University, Shangluo, Shaanxi Province (726000), China
  2.Department of Pharmacy, The Second Affiliated Hospital, Fourth Military Medical University, Xi'an (710038), China
  3.Department of Pharmacology, Xi'an Medical College, Xi'an (710021), China
  4.Department of Medicinal Chemistry, Fourth Military Medical University, Xi'an (710032), China
- Author bio：
  
  Correspondence to: Prof. CHENG Min, Tel: 86-914-2381102, E-mail: exitxiaobai@163.com
- Funds：
  
  Qinling-Bashan Mountains Bioresources Comprehensive Development Collaborative Innovation Center(QBXT-Z(Z)-15-4))
- DOI：10.1007/s11655-018-3050-y
  中图分类号：
- 纸质出版日期：2019-03-01，
  
  网络出版日期：2018-08-30，
  
  录用日期：2016-11-29
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Min CHENG, Xu-hua LIANG, Qing-wei WANG, 等. Ursolic Acid Prevents Retinoic Acid-Induced Bone Loss in Rats[J]. Chinese Journal of Integrative Medicine, 2019,25(3):210-215.

Min CHENG, Xu-hua LIANG, Qing-wei WANG, et al. Ursolic Acid Prevents Retinoic Acid-Induced Bone Loss in Rats[J]. Chinese Journal of Integrative Medicine, 2019,25(3):210-215.
Min CHENG, Xu-hua LIANG, Qing-wei WANG, 等. Ursolic Acid Prevents Retinoic Acid-Induced Bone Loss in Rats[J]. Chinese Journal of Integrative Medicine, 2019,25(3):210-215. DOI： 10.1007/s11655-018-3050-y.

Min CHENG, Xu-hua LIANG, Qing-wei WANG, et al. Ursolic Acid Prevents Retinoic Acid-Induced Bone Loss in Rats[J]. Chinese Journal of Integrative Medicine, 2019,25(3):210-215. DOI： 10.1007/s11655-018-3050-y.

摘要

Abstract

Objective:

To examine the effects of ursolic acid (UA) on mitigating retinoic acid (RA)-induced osteoporosis in rats.

Methods:

Fifty female Sprague-Dawley rats were randomly divided into the control group (

=10) and the osteoporosis group (

=40). The 40 osteoporosis rats were induced by 75 mg/(kg•d) RA once daily for 2 weeks

and then were randomly assigned to vehicle control (model)

low-

middle-

and high-dose UA [(UA-L

UA-M

UA-H; 30

120 mg/(kg•d)

respectively] groups (10 rats each). UA were administered once daily to the rats from the 3rd weeks for up to 4 weeks by gavage. Bone turnover markers [serum alkaline phosphatase (ALP)

osteocalcin (OCN)

urine deoxypyridinoline (DPD)]

and other parameters

including serum calcium (S-Ca)

serum phosphorus (S-P)

urine calcium (U-Ca)

urine phosphorus (U-P)

and bone mineral density (BMD) of the femur

4th lumbar vertebra and tibia

bone biomechanical properties and trabecular microarchitecture

were measured.

Results:

The osteoporosis in rats was successfully induced by RA. Compared with the model group

UA-M and UA-H significantly reversed the RA-induced changes in S-P

U-Ca

U-P

ALP

OCN and urine DPD ratio and markedly enhanced the BMD of right femur

4th lumbar vertebra and tibia (

0.05 or

0.01). Further

biomechanical test and microcomputed tomography evaluation also showed that UA-H drastically improved biomechanical properties and trabecular microarchitecture (

0.05 or

0.01).

Conclusion:

UA could promote bone formation

increase osteoblastic activity and reduce osteoclastic activity in rats

indicating that UA might be a potential therapeutic of RA-induced acute osteoporosis.

关键词

Keywords

osteoporosisbone turnoverursolic acidbone mineral densitybiomechanicsmicrocomputed tomography

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