Clinical Experience in Treatment of Alzheimer's Disease with Jiannao Yizhi Formula (健脑益智方) and Routine Western Medicine
Back to article page
Clinical Experience|Updated:2021-08-23
|
Clinical Experience in Treatment of Alzheimer's Disease with Jiannao Yizhi Formula (健脑益智方) and Routine Western Medicine
Clinical Experience in Treatment of Alzheimer's Disease with Jiannao Yizhi Formula (健脑益智方) and Routine Western Medicine
Chinese Journal of Integrative Medicine2020年26卷第3期 页码:212-218
Affiliations:
1.Graduate School, Beijing University of Chinese Medicine, Beijing (100029), China
2.Department of Geratology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
Author bio:
Correspondence to: Prof. LI Hao, E-mail:xyhplihao1965@126.com
Funds:
Beijing Municipal Science and Technology Project (Capital Characteristic Clinic Project)(Z171100001017106);Beijing Municipal Science and Technology Project "Ten Disease and Ten Medicine"(Z171100001717016)
Hui-chan WANG, Nan-yang LIU, Shuai ZHANG, 等. Clinical Experience in Treatment of Alzheimer's Disease with Jiannao Yizhi Formula (健脑益智方) and Routine Western Medicine[J]. Chinese Journal of Integrative Medicine, 2020,26(3):212-218.
Hui-chan WANG, Nan-yang LIU, Shuai ZHANG, et al. Clinical Experience in Treatment of Alzheimer's Disease with Jiannao Yizhi Formula (健脑益智方) and Routine Western Medicine[J]. Chinese Journal of Integrative Medicine, 2020,26(3):212-218.
Hui-chan WANG, Nan-yang LIU, Shuai ZHANG, 等. Clinical Experience in Treatment of Alzheimer's Disease with Jiannao Yizhi Formula (健脑益智方) and Routine Western Medicine[J]. Chinese Journal of Integrative Medicine, 2020,26(3):212-218. DOI: 10.1007/s11655-019-2717-3.
Hui-chan WANG, Nan-yang LIU, Shuai ZHANG, et al. Clinical Experience in Treatment of Alzheimer's Disease with Jiannao Yizhi Formula (健脑益智方) and Routine Western Medicine[J]. Chinese Journal of Integrative Medicine, 2020,26(3):212-218. DOI: 10.1007/s11655-019-2717-3.
Clinical Experience in Treatment of Alzheimer's Disease with Jiannao Yizhi Formula (健脑益智方) and Routine Western Medicine
摘要
Abstract
Objective:
2
To investigate the long-term therapeutic effects of the Chinese medicine Jiannao Yizhi Formula (健脑益智方
JYF) in the treatment of Alzheimer's disease (AD).
Methods:
2
Sixty mild-to-moderate AD participants were recruited and randomly allocated to the treatment (30 with JYF) and the control groups (30 with donepezil) for 6 months with the random numbers. The primary outcomes were scores of Alzheimer's Disease Rating Scale-Cognitive (ADAS-Cog) and Chinese Medicine Symptom Scale (CM-SS). The secondary outcomes were scores of Mini Mental State Examination (MMSE)
Montreal Cognitive Assessment (MoCA)
and Activities of Daily Living (ADL). Safety assessments were conducted at baseline and the 6th month of treatment. Serum levels of acetylcholine (Ach)
amyloid-β protein 42 (Aβ
42
)
and the microtubule-associated protein tau (Tau) were also determined by enzyme-liked immunosorbent assay.
Results:
2
Fifty-one participants were included in the final analyses (JYF
n
=27; donepezil
n
=24). Compared with baseline
both JYF and donepezil increased the MoCA and MMSE scores and decreased the ADAS-Cog and CM-SS scores (
P
<
0.05 or
P
<
0.01). Both drugs increased the serum levels of Ach and decreased the serum levels of Aβ
42
and Tau (all
P
<
0.05). There was no significant difference in these variables between the two groups
which showed that JYF was not inferior to donepezil. No obviously significant changes were observed in the ADL. No severe adverse events were observed in both groups.
Conclusion:
2
The effect and safety of JYF for the treatment of AD were not inferior to those of donepezil.
Therapeutic Mechanism of Kai Xin San on Alzheimer's Disease Based on Network Pharmacology and Experimental Validation
Mechanisms of Electroacupuncture on Alzheimer's Disease: A Review of Animal Studies
Tiaobu Xinshen Recipe (调补心肾方) Improved Mild Cognitive Impairment of Alzheimer's Disease Patients with Xin (Heart) and Shen (Kidney) Deficiency
Sequential Therapy Based on Evolvement of Patterns: A New Model for Treatment of Alzheimer's Disease
Effect and Safety of Huannao Yicong Formula (还脑益聪方) in Patients with Mild-to-Moderate Alzheimer's Disease: A Randomized, Double-Blinded, Donepezil-Controlled Trial
相关作者
暂无数据
相关机构
The Second Clinical Medical College, Guangzhou University of Chinese Medicine
Department of Hepatology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine
Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
Key Laboratory of Cosmetics Monitoring and Evaluation, State Drug Administration, Shenzhen Institute for Drug Control
The School of Basic Medical Sciences, Hubei University of Chinese Medicine