Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma

Qing-hong SU; Xiao-qun XU; Jun-fu WANG; Jun-wen LUAN; Xia REN; Hai-yan HUANG; Si-shan BIAN

doi:10.1007/s11655-019-2941-x

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Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma

Review | Updated：2021-08-27

- Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma
- Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma
- Chinese Journal of Integrative Medicine 2019年25卷第12期页码：948-955
- Affiliations：
  
  1.Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan (250062), China
  2.Department of Orthopaedics, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan (250014), China
- Author bio：
  
  Correspondence to: Dr. BIAN Si-shan, Tel: 86-531-82919505, E-mail: sdzydfygk@163.com
- Funds：
  
  the Natural Science Foundation of Shandong Province, China(ZR2014HM085);the Project for Shandong Chinese Medicine Science and Technology Plan, China(2013-219)
- DOI：10.1007/s11655-019-2941-x
  中图分类号：
- 纸质出版日期：2019-12-01，
  
  网络出版日期：2019-06-04，
  
  录用日期：2018-04-26
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Qing-hong SU, Xiao-qun XU, Jun-fu WANG, 等. Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma[J]. Chinese Journal of Integrative Medicine, 2019,25(12):948-955.

Qing-hong SU, Xiao-qun XU, Jun-fu WANG, et al. Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma[J]. Chinese Journal of Integrative Medicine, 2019,25(12):948-955.
Qing-hong SU, Xiao-qun XU, Jun-fu WANG, 等. Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma[J]. Chinese Journal of Integrative Medicine, 2019,25(12):948-955. DOI： 10.1007/s11655-019-2941-x.

Qing-hong SU, Xiao-qun XU, Jun-fu WANG, et al. Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma[J]. Chinese Journal of Integrative Medicine, 2019,25(12):948-955. DOI： 10.1007/s11655-019-2941-x.

摘要

Abstract

Osteosarcoma is a rare primary malignancy of bone that is prone to early metastasis. Resection surgery and chemotherapeutic regimens are current standard treatments for osteosarcoma. However

the long-term survival rate of patients with osteosarcoma is low due to a high risk of metastasis. Hence

a new approach is urgently needed to improve the treatment of osteosarcoma. Compared with chemotherapy

natural active constituents isolated from herbs exhibit less adverse effects and better anti-tumor effects. This study aimed to summarize the anticancer effects of constituents of herbs on the progression and metastasis of osteosarcoma cells. It showed that many constituents of herbs inhibited osteosarcoma by targeting proliferation

matrix metalloproteinases

integrin and cadherin

and angiogenesis. The findings might be beneficial for the development of new drugs and treatment strategies.

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constituents of herbsosteosarcomametastasisreview

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