Impact of Hydroalcoholic Extract of <italic style="font-style: italic">Humulus Lupulus</italic> L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats

Narges Karbalaei; Najmeh Sadeghi; Aliakbar Nekoeian; Ahad Malekzadeh

doi:10.1007/s11655-019-3025-7

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Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats

Original Article | Updated：2021-08-27

- Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats
- Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats
- Chinese Journal of Integrative Medicine 2019年25卷第7期页码：529-535
- Affiliations：
  
  1.Department of Physiology, Physiology Research Center, School of Medicine, Medical Sciences University of Shiraz(71348-45794), Iran
  2.Department of Medical Physiology, School of Medicine, Jahrom University of Medical Sciences, Jahrom (74148-44196), Iran
  3.Department of Pharmacology, Pharmacology Research Center, School of Medicine, Medical Sciences University of Shiraz(71348-45794), Iran
  4.Department of Mathematics, K.N. Toosi University of Technology, Tehran (16315-1618), Iran
- Author bio：
  
  Correspondence to: Prof. Najmeh Sadeghi, Tel: 98-54340505, E-mail:nsadeghi@yahoo.com, najmeh.sadeghi@gmail.com
- Funds：
  
  the Research Affairs of Shiraz University of Medical Sciences(3001)
- DOI：10.1007/s11655-019-3025-7
  中图分类号：
- 纸质出版日期：2019-07-01，
  
  网络出版日期：2019-02-27，
  
  录用日期：2016-08-30
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Narges Karbalaei, Najmeh Sadeghi, Aliakbar Nekoeian, 等. Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats[J]. Chinese Journal of Integrative Medicine, 2019,25(7):529-535.

Narges Karbalaei, Najmeh Sadeghi, Aliakbar Nekoeian, et al. Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats[J]. Chinese Journal of Integrative Medicine, 2019,25(7):529-535.
Narges Karbalaei, Najmeh Sadeghi, Aliakbar Nekoeian, 等. Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats[J]. Chinese Journal of Integrative Medicine, 2019,25(7):529-535. DOI： 10.1007/s11655-019-3025-7.

Narges Karbalaei, Najmeh Sadeghi, Aliakbar Nekoeian, et al. Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats[J]. Chinese Journal of Integrative Medicine, 2019,25(7):529-535. DOI： 10.1007/s11655-019-3025-7.

摘要

Abstract

Objective:

To investigate the impact of

Humulus Lupulus

L. hydroalcoholic extract on the body weights

reproductive organs

sperm quality and hormone levels in male rats.

Methods:

By simple random sampling method

seventy male Sprague-Dawley rats were randomly assigned to 7 groups including control group [distilled water

1 mL/(kg•d)]

Tween 80 group [25% Tween 80 solution

1 mL/(kg•d)]

olive oil group [olive oil

1 mL/(kg•d)]

diethyl stilbestrol (DES) group [DES

100 μg/(kg•body weight)]

H50

H150 and H450 [50

150 and 400 mg/(kg•d) of

Humulus Lupulus

L extract

respectively]. The administration was performed via gavage once daily for 7 weeks. Body and reproductive organs weights including testes

seminal vesicles

epididymis and prostate were weighted and epididymal sperm quality were determined by digital balance. Blood samples were collected and serum free testosterone (T)

luteinizing hormone (LH)

follicle-stimulating hormone (FSH)

and estrogen (E

) levels were measured by rat specific enzyme-linked immunosorbent assay.

Results:

The percentage increase in mean body weights of rats in the DES and H50

H150 and H450 groups decreased significantly compared to olive oil and Tween 80 groups (all

0.05). The weights of seminal vesicle

epididymis and testes in rats receiving H50 were significantly higher than the control group (

0.05 or

0.01). The sperm count in the rats receiving H50 was significantly lower than the control group (

0.05). The sperm motile characteristics of the rats receiving hydroalcoholic extract and DES were significantly lower than those of the control or rats receiving vehicles (all

0.05). In H50

H150

H450 and DES groups

T and LH levels were decreased

and E2 was significantly increased compared to the control (

0.05 or

0.01). The FSH level did not change in all groups (

0.05).

Conclusion:

Humulus Lupulus

L. extract significantly increased the seminal vesicle and testes weights and reduced the sperm motility.

关键词

Keywords

sex organphytoestrogenHumulus Lupulus L.sperm qualitymale rat

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Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats

Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats

DOI：10.1007/s11655-019-3025-7

摘要

Abstract

关键词

Keywords

references