Efficacy and Safety Evaluation of Taohong Siwu Decoction(桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials

Tian-qi TAO; Hui-min MAO; Lei XIA; Xiu-hua LIU

doi:10.1007/s11655-019-3028-4

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Efficacy and Safety Evaluation of Taohong Siwu Decoction(桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials

Evidence-Based Integrative Medicine | Updated：2021-09-01

- Efficacy and Safety Evaluation of Taohong Siwu Decoction(桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials
- Efficacy and Safety Evaluation of Taohong Siwu Decoction(桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials
- Chinese Journal of Integrative Medicine 2021年27卷第8期页码：626-632
- Affiliations：
  
  1.Department of Pathophysiology, Chinese PLA General Hospital, Beijing(100853), China
  2.Department of Nephrology, Guang'anmen Hospital, Beijing(100053), China
- Author bio：
  
  Prof. LIU Xiu-hua, E-mail: xiuhualiu98@163.com
- Funds：
  
  National Basic Research Program of China (973 Program)(2015CB554402;2015CB554405);National Natural Science Foundation of China(31771287)
- DOI：10.1007/s11655-019-3028-4
  中图分类号：
- 纸质出版日期：2021-08-01，
  
  网络出版日期：2019-04-02，
  
  录用日期：2017-05-30
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Tian-qi TAO, Hui-min MAO, Lei XIA, 等. Efficacy and Safety Evaluation of Taohong Siwu Decoction(桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials[J]. Chinese Journal of Integrative Medicine, 2021,27(8):626-632.

Tian-qi TAO, Hui-min MAO, Lei XIA, et al. Efficacy and Safety Evaluation of Taohong Siwu Decoction(桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials[J]. Chinese Journal of Integrative Medicine, 2021,27(8):626-632.
Tian-qi TAO, Hui-min MAO, Lei XIA, 等. Efficacy and Safety Evaluation of Taohong Siwu Decoction(桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials[J]. Chinese Journal of Integrative Medicine, 2021,27(8):626-632. DOI： 10.1007/s11655-019-3028-4.

Tian-qi TAO, Hui-min MAO, Lei XIA, et al. Efficacy and Safety Evaluation of Taohong Siwu Decoction(桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials[J]. Chinese Journal of Integrative Medicine, 2021,27(8):626-632. DOI： 10.1007/s11655-019-3028-4.

摘要

Abstract

Objective:

To assess the efficacy and safety of Taohong Siwu Decoction (桃红四物汤

TSD)

a Chinese herbal compound prescription

in patients with angina pectoris (AP).

Methods:

Randomized clinical trials (RCTs) comparing TSD plus conventional treatment (CT) with CT plus placebo or CT only in the patients with AP were searched in PubMed

Cochrane Library

Excerpta Medica Database

Chinese National Knowledge Infrastructure

Chinese Biomedical Literature Database

Wanfang Database

Chinese Scientific Journal Database

Chinese Clinical Trial Registry and International Clinical Trial Registry from their inception to March 2017. The primary outcomes include a composite event of death

acute myocardial infarction (AMI)

and target vessel revascularization. The secondary outcomes include angina symptom

electrocardiogram (ECG) improvement and serum high-sensitivity C-reactive protein (hs-CRP)

endothelin-1 (ET-1)

triglycerides (TG)

total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels. The methodological quality of included studies and extracted available data were assessed. RevMan 5.3 software was used to conduct statistical analysis. The relative risk (RR) and standardized mean difference (SMD) with 95% confidence interval (CI) was calculated. A funnel plot was used to evaluate the publication bias.

Results:

Among 204 studies identified in the literature search

12 trials including 959 patients with AP met the inclusion criteria. No studies reported the primary outcome including death

AMI and target vessel revascularization. TSD combined with CT showed significant improvement in relieving angina symptom [RR=3.70

95% CI (2.42

5.67)] and ECG [RR=3.20

95% CI (2.20

4.65)] compared with CT alone. TSD combined with CT reduced the serum hs-CRP

TC and LDL-C levels compared with CT alone. No serious adverse events were reported in TSD combined with CT.

Conclusions:

TSD combined with CT has a potential benefit on relieving AP without significant adverse events. However

the efficacy on the cardiovascular events needs to be assessed by more rigorously-designed

largescale

and multi-center RCTs in future.

关键词

Keywords

Taohong Siwu Decoctionsystematic reviewmeta-analysisangina pectorisrandomized controlled trialChinese medicine

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