Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

Ting-ting LUO; Yuan LU; Shi-kai YAN; Xue XIAO; Xiang-lu RONG; Jiao GUO

doi:10.1007/s11655-019-3064-0

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Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

Review | Updated：2021-08-27

- Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective
- Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective
- Chinese Journal of Integrative Medicine 2020年26卷第1期页码：72-80
- Affiliations：
  
  1.Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou (510006), China
  2.Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou (510006), China
  3.School of Pharmacy, Shanghai Jiao Tong University, Shanghai (200240), China
- Author bio：
  
  Correspondence to: Prof. GUO Jiao, E-mail:gyguogy@163.com
- Funds：
  
  the National Natural Science Foundation of China(81530102);Guangdong Provincial Science and Technology Agency Special Funds(2017B050504005);Guangzhou City Science and Technology Agency Special Funds(201803010069)
- DOI：10.1007/s11655-019-3064-0
  中图分类号：
- 纸质出版日期：2020-01-01，
  
  网络出版日期：2019-04-02，
  
  录用日期：2018-11-28
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Ting-ting LUO, Yuan LU, Shi-kai YAN, 等. Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective[J]. Chinese Journal of Integrative Medicine, 2020,26(1):72-80.

Ting-ting LUO, Yuan LU, Shi-kai YAN, et al. Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective[J]. Chinese Journal of Integrative Medicine, 2020,26(1):72-80.
Ting-ting LUO, Yuan LU, Shi-kai YAN, 等. Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective[J]. Chinese Journal of Integrative Medicine, 2020,26(1):72-80. DOI： 10.1007/s11655-019-3064-0.

Ting-ting LUO, Yuan LU, Shi-kai YAN, et al. Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective[J]. Chinese Journal of Integrative Medicine, 2020,26(1):72-80. DOI： 10.1007/s11655-019-3064-0.

摘要

Abstract

Chinese medicine (CM) is usually prescribed as CM formula to treat disease. The lack of effective research approach makes it difficult to elucidate the molecular mechanisms of CM formula owing to its complicated chemical compounds. Network pharmacology is increasingly applied in CM formula research in recent years

which is identified suitable for the study of CM formula. In this review

we summarized the methodology of network pharmacology

including network construction

network analysis and network verification. The aim of constructing a network is to achieve the interaction between the bioactive compounds and targets and the interaction between various targets

and then find out and validate the key nodes via network analysis and network verification. Besides

we reviewed the application in CM formula research

mainly including targets discovery

bioactive compounds screening

toxicity evaluation

mechanism research and quality control research. Finally

we proposed prospective in the future and limitations of network pharmacology

expecting to provide new strategy and thinking on study for CM formula.

关键词

Keywords

network pharmacologyChinese medicine formulatargets discoverymechanism researchquality control research

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