Effect of Shexiang Baoxin Pill (麝香保心丸) in Alleviating Early Hypertensive Renal Injury in Rats

Jia-hui ZHAO; Lei ZHANG; Yang LIU; Qing-li CHENG

doi:10.1007/s11655-019-3162-z

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Effect of Shexiang Baoxin Pill (麝香保心丸) in Alleviating Early Hypertensive Renal Injury in Rats

Original Article | Updated：2021-08-16

- Effect of Shexiang Baoxin Pill (麝香保心丸) in Alleviating Early Hypertensive Renal Injury in Rats
- Effect of Shexiang Baoxin Pill (麝香保心丸) in Alleviating Early Hypertensive Renal Injury in Rats
- Chinese Journal of Integrative Medicine 2021年27卷第1期页码：47-53
- Affiliations：
  
  Department of Geriatric Nephrology, Chinese PLA General Hospital, Beijing (100853), China
- Author bio：
  
  Correspondence to: Prof. ZHAO Jia-hui, E-mail: zjhpk301@163.com
- Funds：
- DOI：10.1007/s11655-019-3162-z
  中图分类号：
- 纸质出版日期：2021-01-01，
  
  网络出版日期：2019-06-11，
  
  录用日期：2018-10-19
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Jia-hui ZHAO, Lei ZHANG, Yang LIU, 等. Effect of Shexiang Baoxin Pill (麝香保心丸) in Alleviating Early Hypertensive Renal Injury in Rats[J]. Chinese Journal of Integrative Medicine, 2021,27(1):47-53.

Jia-hui ZHAO, Lei ZHANG, Yang LIU, et al. Effect of Shexiang Baoxin Pill (麝香保心丸) in Alleviating Early Hypertensive Renal Injury in Rats[J]. Chinese Journal of Integrative Medicine, 2021,27(1):47-53.
Jia-hui ZHAO, Lei ZHANG, Yang LIU, 等. Effect of Shexiang Baoxin Pill (麝香保心丸) in Alleviating Early Hypertensive Renal Injury in Rats[J]. Chinese Journal of Integrative Medicine, 2021,27(1):47-53. DOI： 10.1007/s11655-019-3162-z.

Jia-hui ZHAO, Lei ZHANG, Yang LIU, et al. Effect of Shexiang Baoxin Pill (麝香保心丸) in Alleviating Early Hypertensive Renal Injury in Rats[J]. Chinese Journal of Integrative Medicine, 2021,27(1):47-53. DOI： 10.1007/s11655-019-3162-z.

摘要

Abstract

Objective:

To investigate the effect of Shexiang Baoxin Pill (麝香保心丸

SBP) on early hypertensive renal injury in rats and to explore the possible mechanism.

Methods:

Twelve-week-old spontaneous hypertensive rats (SHRs) with high-salt diet (dietary containing 8% NaCl) were randomized into the SBP group [40 mg/(kg•d)]

losartan potassium group [20 mg/(kg•d)] and saline group by stratified random sampling method

12 in each group. Blood pressure and urea albumin creatinine ratio were measured. After 10 weeks

the expression levels of serum creatinine (Scr)

hypersensitive C-reactive protein (hs-CRP)

interleukin (IL)-1β

IL-6

tumor necrosis factor α (TNF-α)

and transforming growth factor β (TGF-β) in serum were assessed. Kidney pathology periodate-schiff staining was performed. Semi-quantitative count of macrophage infiltration was determined by immunochemistry of CD68 staining. Real-time quantitative polymerase chain reaction and Western blot were performed to examine the mRNA and protein expressions of Toll-like receptor 4 (TLR4)

nuclear factor κB (NF-κB)

monocyte chemokine peptide (MCP-1)

inducible nitric oxide synthase (iNOS)

and arginase-1 (Arg-1).

Results:

SBP did not affect the mortality of SHR (

0.05). SBP significantly reduced the level of elevated blood pressure of SHRs

but the effect was less significantly than that of losartan potassium. SBP decreased urine protein (

0.01) and the expression levels of IL-1β

IL-6

TNF-α

and TGF-β in serum. The 22-week-old SHRs showed mild proliferation of glomerular endothelial cells

glomerular ischemic lesions

inflammatory cell infiltration in renal tubular interstitium and arteriosclerosis. Both SBP and losartan potassium had alleviated renal pathological change

and significantly reduced the infiltration of macrophage (

0.05

0.01). SBP and losartan potassium decreased the expressions of TLR4

NF-κB

MCP-1

iNOS

and Arg-1.

Conclusion:

SBP significantly modified the early hypertensive renal injury by reducing inflammation

and the effect was similar to losartan potassium.

关键词

Keywords

hypertensionkidney injuryShexiang Baoxin PillChinese medicineinflammation

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