Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment

Ai-ping TIAN; Yu-kun YIN; Lei YU; Bo-yan YANG; Ning LI; Jian-ying LI; Zhi-min BIAN; Shang-ying HU; Chun-xiao WENG; Li FENG

doi:10.1007/s11655-019-3167-7

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Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment

Original Article | Updated：2021-08-23

- Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment
- Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment
- Chinese Journal of Integrative Medicine 2020年26卷第4期页码：263-269
- Affiliations：
  
  1.Department of Traditional Chinese Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (100021), China
  2.Department of Comprehensive Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (100021), China
  3.Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (100021), China
  4.Beijing Chiamery Medical Sciences Institute, Beijing (100080), China
- Author bio：
  
  Correspondence to: Prof. FENG Li, E-mail:Fengli8535@163.com
- Funds：
  
  the Fund for Beijing Science & Technology Development of TCM(JJ2015-65)
- DOI：10.1007/s11655-019-3167-7
  中图分类号：
- 纸质出版日期：2020-04-01，
  
  网络出版日期：2019-08-24，
  
  录用日期：2019-02-11
Scan for full text
Ai-ping TIAN, Yu-kun YIN, Lei YU, 等. Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment[J]. Chinese Journal of Integrative Medicine, 2020,26(4):263-269.

Ai-ping TIAN, Yu-kun YIN, Lei YU, et al. Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment[J]. Chinese Journal of Integrative Medicine, 2020,26(4):263-269.
Ai-ping TIAN, Yu-kun YIN, Lei YU, 等. Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment[J]. Chinese Journal of Integrative Medicine, 2020,26(4):263-269. DOI： 10.1007/s11655-019-3167-7.

Ai-ping TIAN, Yu-kun YIN, Lei YU, et al. Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment[J]. Chinese Journal of Integrative Medicine, 2020,26(4):263-269. DOI： 10.1007/s11655-019-3167-7.

摘要

Abstract

Objective:

To evaluate whether low-frequency ultrasound-facilitated transdermal delivery of a Chinese medicine (CM) formula could improve the efficacy of intrapleural administration of interleukin-2 (IL-2) in treatment of malignant pleural effusion (MPE).

Methods:

A total of 110 eligible participants were randomized into the low-frequency sonophoresis (LFS) of CM (LSF/CM) group (55 cases) and the control group (55 cases) by simple randomization using a random number table. The control group was treated with an intrapleural administration of IL-2; and the LFS/CM group was treated with LFS of a CM gel formulation

combined with the same IL-2 injection as in the control group. The CM formula consisted of

Semen Lepidii

Semen Sinapis

Ramulus Cinnamomi

Poriacocos

Herba Lycopi

and

Radix Paeoniae Rubra

. After 2-week treatment

the therapeutic outcome was determined by the change of the amount of MPE

which was evaluated by B-scan ultrasound and/or chest X-ray

and the change of quality of life (QOL) scores

which were evaluated by the Eastern Cooperative Oncology Group (ECOG) performance status.

Results:

A significantly higher objective remission rate (ORR) was obtained with intrapleural IL-2 plus LFS/CM than IL-2 treatment alone (

=0.049). In addition

more patients in the LFS/CM group than in the control group had an improved QOL score (

=0.048)

and no patients in the LFS/CM group had a reduced QOL.

Conclusion:

LFS of CM formulation could effectively alleviate MPE and improve the QOL of cancer patients.

关键词

Keywords

malignant pleural effusionlow-frequency ultrasonic penetrationChinese medicinerandomized controlled trial

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