Combination of Chinese and Western Medicine to Prevent and Reverse Resistance of Cancer Cells to Anticancer Drugs

Xin-bing SUI; Tian XIE

doi:10.1007/s11655-019-3180-x

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Combination of Chinese and Western Medicine to Prevent and Reverse Resistance of Cancer Cells to Anticancer Drugs

Feature Article | Updated：2021-08-23

- Combination of Chinese and Western Medicine to Prevent and Reverse Resistance of Cancer Cells to Anticancer Drugs
- Combination of Chinese and Western Medicine to Prevent and Reverse Resistance of Cancer Cells to Anticancer Drugs
- Chinese Journal of Integrative Medicine 2020年26卷第4期页码：251-255
- Affiliations：
  
  1.Holistic Integrative Pharmacy Institutes and Comprehensive Cancer Diagnosis and Treatment Center, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou (311121), China
  2.Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou Normal University, Hangzhou (311121), China
- Author bio：
  
  Correspondence to: Prof. XIE Tian, E-mail:drxiet@aliyun.com
- Funds：
  
  the National Natural Science Foundation of China(81672932;81730108;81874380;81973635);Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars(LR18H160001);Zhejiang Province Science and Technology Project of TCM(2019ZZ016);Zhejiang Province Medical Science and Technology Project(2017RC007);Talent Project of Zhejiang Association for Science and Technology(2017YCGC002);Key Project of Hangzhou Ministry of Science and Technology(20162013A07)
- DOI：10.1007/s11655-019-3180-x
  中图分类号：
- 纸质出版日期：2020-04-01，
  
  网络出版日期：2019-11-09，
  
  录用日期：2019-10-09
Scan for full text
Xin-bing SUI, Tian XIE. Combination of Chinese and Western Medicine to Prevent and Reverse Resistance of Cancer Cells to Anticancer Drugs[J]. Chinese Journal of Integrative Medicine, 2020,26(4):251-255.

Xin-bing SUI, Tian XIE. Combination of Chinese and Western Medicine to Prevent and Reverse Resistance of Cancer Cells to Anticancer Drugs[J]. Chinese Journal of Integrative Medicine, 2020,26(4):251-255.
Xin-bing SUI, Tian XIE. Combination of Chinese and Western Medicine to Prevent and Reverse Resistance of Cancer Cells to Anticancer Drugs[J]. Chinese Journal of Integrative Medicine, 2020,26(4):251-255. DOI： 10.1007/s11655-019-3180-x.

Xin-bing SUI, Tian XIE. Combination of Chinese and Western Medicine to Prevent and Reverse Resistance of Cancer Cells to Anticancer Drugs[J]. Chinese Journal of Integrative Medicine, 2020,26(4):251-255. DOI： 10.1007/s11655-019-3180-x.

摘要

Abstract

Resistance to anticancer drugs is a major problem in oncology

which causes the failure of antitumor treatment. A variety of factors contribute to drug resistance

including drug efflux and metabolism

tumor cell heterogeneity

tumor microenvironment stress-induced genetic or epigenetic alterations in the cancer cells and so on. However

how to circumvent this resistance to improve anticancer efficacy remains to be determined. To circumvent chemotherapeutic resistance

many reversal agents have been developed

but most of them fail in clinical trials due to severe adverse effects. Recently

several natural products have been reported to augment sensitivity or overcome resistance of anticancer chemotherapeutic drugs

including elemene

curcumin

Shenqi Fuzheng Injection (参芪扶正注射液)

PHY906

etc. Thus

understanding the novel function of Chinese medicine may allow us to develop a promising therapeutic approach to enhance the effects of anticancer strategies and prevent or overcome their resistance in the treatment of cancer patients.

关键词

Keywords

Chinese medicineWestern medicineintegrative Chinese and Western medicineresistanceanticancer drugs

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