Phonopheresis Associated with Nanoparticle Gel from <italic style="font-style: italic">Phyllanthus amarus</italic> Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis

Decha Pinkaew; Kanokwan Kiattisin; Jiraporn Tocharus; Pichaya Jumnongprakhon; Pisittawoot Awoot

doi:10.1007/s11655-019-3202-8

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Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis

Clinical Experience | Updated：2021-08-27

- Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis
- Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis
- Chinese Journal of Integrative Medicine 2019年25卷第9期页码：691-695
- Affiliations：
  
  1.Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand
  2.Department of Pharmaceutical Sciences. Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand
  3.Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
  4.Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand
  5.Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
- Author bio：
  
  Correspondence to: Dr. Decha Pinkaew, Tel: 0084-6873443; E-mail: Decha303@gmail.com
- Funds：
  
  CMU Junior Research Fellowship Program and the Faculty of Associated Medical Sciences, Chiang Mai University, Thailand(8/2560)
- DOI：10.1007/s11655-019-3202-8
  中图分类号：
- 纸质出版日期：2019-09-01，
  
  录用日期：2019-04-17
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Decha Pinkaew, Kanokwan Kiattisin, Jiraporn Tocharus, 等. Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis[J]. Chinese Journal of Integrative Medicine, 2019,25(9):691-695.

Decha Pinkaew, Kanokwan Kiattisin, Jiraporn Tocharus, et al. Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis[J]. Chinese Journal of Integrative Medicine, 2019,25(9):691-695.
Decha Pinkaew, Kanokwan Kiattisin, Jiraporn Tocharus, 等. Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis[J]. Chinese Journal of Integrative Medicine, 2019,25(9):691-695. DOI： 10.1007/s11655-019-3202-8.

Decha Pinkaew, Kanokwan Kiattisin, Jiraporn Tocharus, et al. Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis[J]. Chinese Journal of Integrative Medicine, 2019,25(9):691-695. DOI： 10.1007/s11655-019-3202-8.

摘要

Abstract

Objective:

To determine the changes in serum levels of inflammatory biomarkers and antioxidant levels among the knee osteoarthritis (OA) patients after treatment with Phyllanthus amarus (PP) by nanoparticle gel phonophoresis.

Methods:

This study was a randomized

double-blind

placebo-control

parallel-group

clinical trial involving 30 subjects with mild-to-moderate degree of knee OA. The patients were allocated to two groups using a computer-generated random numbers

and received conventional ultrasound therapy (control group

15 cases) and PP (treatment group

15 cases) once daily for 10 sessions. The pain was evaluated by visual analogue scale (VAS). Serum levels of tumor necrosis factor-α (TNF-α) were determined by enzyme-linked immunosorbnent assay (ELISA). Nitric oxide (NO) was determined by modified Griess reagent. The antioxidant effects

including superoxide dismutase (SOD) and total antioxidant capacity (TAC)

were also measured by ELISA assay.

Results:

The VAS score was significantly decreased in the treatment group compared with the control group after treatment (

0.01). The serum concentrations of TNF-α and NO were significantly reduced in the treatment group compared with the control group (

0.01) after treatment. However

the serum concentrations of SOD and TAC in the treatment group were significantly higher after treatment compared with the control group (

0.01).

Conclusion:

PP could alleviate knee pain and significantly reduce systemic antiinflammatory effects in knee OA patients.

关键词

Keywords

phonopheresis associated with nanoparticle gel from Phyllanthus amarusosteoarthritisproinflammatory cytokinesantioxidantstumor necrosis factor-αtotal antioxidant capacity

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Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis

Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis

DOI：10.1007/s11655-019-3202-8

摘要

Abstract

关键词

Keywords

references