Edible Bird's Nest Attenuates Menopause-Related Bone Degeneration in Rats via Increasing Bone Estrogen-Receptor Expression

Zhi-ping HOU; Shi-ying TANG; Hai-ru JI; Pei-yuan HE; Yu-hong LI; Xian-ling DONG; Meng-nan DU; Maznah Ismail; Wen-jing HE

doi:10.1007/s11655-019-3209-1

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Edible Bird's Nest Attenuates Menopause-Related Bone Degeneration in Rats via Increasing Bone Estrogen-Receptor Expression

Original Article | Updated：2021-08-16

- Edible Bird's Nest Attenuates Menopause-Related Bone Degeneration in Rats via Increasing Bone Estrogen-Receptor Expression
- Edible Bird's Nest Attenuates Menopause-Related Bone Degeneration in Rats via Increasing Bone Estrogen-Receptor Expression
- Chinese Journal of Integrative Medicine 2021年27卷第4期页码：280-285
- Affiliations：
  
  1.Department of Pathology, Chengde Medical University, Chengde, Hebei Province (067000), China
  2.Department of Gastroenterology, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei Province (067000), China
  3.Department of Pathology The Affiliated Hospital of Hebei University, Baoding, Hebei Province (071000), China
  4.Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor (43400), Malaysia
  5.Department of Gastroscopy, Kuancheng Manchu Autonomous County Hospital, Chengde, Hebei Province (067000), China
- Author bio：
  
  Correspondence to: Dr. HOU Zhi-ping, E-mail: zhipinghou@163.com
- Funds：
  
  Grants from Ministry of Science, Technology and Innovation, E-science Fund, Malaysia;the Health and Family Planning Commission of Hebei;the Administration of Traditional Chinese Medicine of Hebei;the Key Discipline Construction Project of Hebei Provincial Universities;Start up Fund for High Level Talents of Chengde Medical University
- DOI：10.1007/s11655-019-3209-1
  中图分类号：
- 纸质出版日期：2021-04-01，
  
  网络出版日期：2019-12-23，
  
  录用日期：2019-08-21
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Zhi-ping HOU, Shi-ying TANG, Hai-ru JI, 等. Edible Bird's Nest Attenuates Menopause-Related Bone Degeneration in Rats via Increasing Bone Estrogen-Receptor Expression[J]. Chinese Journal of Integrative Medicine, 2021,27(4):280-285.

Zhi-ping HOU, Shi-ying TANG, Hai-ru JI, et al. Edible Bird's Nest Attenuates Menopause-Related Bone Degeneration in Rats via Increasing Bone Estrogen-Receptor Expression[J]. Chinese Journal of Integrative Medicine, 2021,27(4):280-285.
Zhi-ping HOU, Shi-ying TANG, Hai-ru JI, 等. Edible Bird's Nest Attenuates Menopause-Related Bone Degeneration in Rats via Increasing Bone Estrogen-Receptor Expression[J]. Chinese Journal of Integrative Medicine, 2021,27(4):280-285. DOI： 10.1007/s11655-019-3209-1.

Zhi-ping HOU, Shi-ying TANG, Hai-ru JI, et al. Edible Bird's Nest Attenuates Menopause-Related Bone Degeneration in Rats via Increasing Bone Estrogen-Receptor Expression[J]. Chinese Journal of Integrative Medicine, 2021,27(4):280-285. DOI： 10.1007/s11655-019-3209-1.

摘要

Abstract

Objective:

To investigate the mechanistic basis for the attenuation of bone degeneration by edible bird's nest (EBN) in ovariectomized rats.

Methods:

Forty-two female Sprage-Dawley rats were randomized into 7 groups (6 in each group). The ovariectomized (OVX) and OVX + 6%

and 1.5% EBN and OVX +estrogen groups were given standard rat chow alone

standard rat chow +6%

and 1.5% EBN

or standard rat chow +estrogen therapy (0.2mg/kg per day)

respectively. The sham-operation group was surgically opened without removing the ovaries. The control group did not have any surgical intervention. After 12 weeks of intervention

blood samples were taken for serum estrogen

osteocalcin

and osteoprotegerin

as well as the measurement of magnesium

calcium abd zinc concentrations. While femurs were removed from the surrounding muscles to measure bone mass density using the X-ray edge detection technique

then collected for histology and estrogen receptor (ER) immunohistochemistry.

Results:

Ovariectomy altered serum estrogen levels resulting in increased food intake and weight gain

while estrogen and EBN supplementation attenuated these changes. Ovariectomy also reduced bone ER expression and density

and the production of osteopcalcin and osteorotegerin

which are important pro-osteoplastic hormones that promote bone mineraliztion and density. Conversely

estrogen and EBN increased serum estrogen levels leading to increased bone ER expression

pro-osteoplastic hormone production and bone density (all

0.05).

Conclusion:

EBN could be used as a safe alternative to hormone replacement therapys for managing menopausal complications like bone degeneration.

关键词

Keywords

edible bird's nestmenopauseovariectomyratsboneosteoporosis

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