Leonurine: From Gynecologic Medicine to Pleiotropic Agent

Yun-yun LI; Yi-kong LIN; Xin-hua LIU; Li WANG; Min YU; Da-jin LI; Yi-zhun ZHU; Mei-rong DU

doi:10.1007/s11655-019-3453-0

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Leonurine: From Gynecologic Medicine to Pleiotropic Agent

Review | Updated：2021-08-23

- Leonurine: From Gynecologic Medicine to Pleiotropic Agent
- Leonurine: From Gynecologic Medicine to Pleiotropic Agent
- Chinese Journal of Integrative Medicine 2020年26卷第2期页码：152-160
- Affiliations：
  
  1.NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai (200011), China
  2.Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai (200011), China
  3.Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai (201203), China
  4.State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau SAR, China
- Author bio：
  
  Correspondence to: Prof. DU Mei-rong, Fax: 86-21-63457331, E-mail:dmrlq1973@sina.cn
- Funds：
- DOI：10.1007/s11655-019-3453-0
  中图分类号：
- 纸质出版日期：2020-02-01，
  
  网络出版日期：2019-05-08，
  
  录用日期：2018-11-05
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Yun-yun LI, Yi-kong LIN, Xin-hua LIU, 等. Leonurine: From Gynecologic Medicine to Pleiotropic Agent[J]. Chinese Journal of Integrative Medicine, 2020,26(2):152-160.

Yun-yun LI, Yi-kong LIN, Xin-hua LIU, et al. Leonurine: From Gynecologic Medicine to Pleiotropic Agent[J]. Chinese Journal of Integrative Medicine, 2020,26(2):152-160.
Yun-yun LI, Yi-kong LIN, Xin-hua LIU, 等. Leonurine: From Gynecologic Medicine to Pleiotropic Agent[J]. Chinese Journal of Integrative Medicine, 2020,26(2):152-160. DOI： 10.1007/s11655-019-3453-0.

Yun-yun LI, Yi-kong LIN, Xin-hua LIU, et al. Leonurine: From Gynecologic Medicine to Pleiotropic Agent[J]. Chinese Journal of Integrative Medicine, 2020,26(2):152-160. DOI： 10.1007/s11655-019-3453-0.

摘要

Abstract

Leonurus japonicus

Houtt

a Chinese traditional herbal medicine

has been widely used to cure gynecological diseases

such as incomplete abortion and menoxenia. Leonurine

a major active alkaloid compound only be found in

Leonurus japonicus

Houtt

has been successfully extracted and purified. Recent evidence has shown that leonurine can regulate a variety of pathologic processes including oxidative stress

inflammation

fibrosis

apoptosis

and multiple metabolic disorders. Here

we have reviewed the pharmacological actions and biological functions of leonurine

with a focus on the role of leonurine in the amelioration of various pathological processes. Insights into the related signaling pathways and molecular mechanisms have strengthened our understanding on the function of leonurine in the alleviation of multiple pathological states. Our summary of the existing researches should help direct future research into the basic science and clinical applications in related diseases.

关键词

Keywords

leonurineLeonurus japonicus HouttChinese medicineoxidative stressinflammationfibrosisclinical application

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