Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via A Network Pharmacology Approach

Zi-qi MENG; Jia-rui WU; Ying-li ZHU; Wei ZHOU; Chang-geng FU; Xin-kui LIU; Shu-yu LIU; Meng-wei NI; Si-yu GUO

doi:10.1007/s11655-020-2716-4

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Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via A Network Pharmacology Approach

Methodology Research | Updated：2021-08-16

- Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via A Network Pharmacology Approach
- Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via A Network Pharmacology Approach
- Chinese Journal of Integrative Medicine 2021年27卷第1期页码：62-69
- Affiliations：
  
  1.Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing(100029), China
  2.Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
- Author bio：
  
  Correspondence to: Prof. WU Jia-rui, E-mail: exogamy@163.com
- Funds：
  
  the National Natural Science Foundation of China;Young Scientists Training Program of Beijing University of Chinese Medicine;Cooperation Project of Beijing University of Chinese Medicine and Kunming Longjin Pharmaceutical
- DOI：10.1007/s11655-020-2716-4
  中图分类号：
- 纸质出版日期：2021-01-01，
  
  网络出版日期：2020-05-22，
  
  录用日期：2019-08-28
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Zi-qi MENG, Jia-rui WU, Ying-li ZHU, 等. Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via A Network Pharmacology Approach[J]. Chinese Journal of Integrative Medicine, 2021,27(1):62-69.

Zi-qi MENG, Jia-rui WU, Ying-li ZHU, et al. Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via A Network Pharmacology Approach[J]. Chinese Journal of Integrative Medicine, 2021,27(1):62-69.
Zi-qi MENG, Jia-rui WU, Ying-li ZHU, 等. Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via A Network Pharmacology Approach[J]. Chinese Journal of Integrative Medicine, 2021,27(1):62-69. DOI： 10.1007/s11655-020-2716-4.

Zi-qi MENG, Jia-rui WU, Ying-li ZHU, et al. Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via A Network Pharmacology Approach[J]. Chinese Journal of Integrative Medicine, 2021,27(1):62-69. DOI： 10.1007/s11655-020-2716-4.

摘要

Abstract

Objective:

To investigate the shared mechanisms of scutellarin in angina pectoris (AP) and ischemic stroke (IS) treatment.

Methods:

A network pharmacology approach was used to detect the potential mechanisms of scutellarin in AP and IS treatment by target prediction

protein-protein interaction (PPI) data collection

network construction

network analysis

and enrichment analysis. Furthermore

molecular docking simulation was employed to analyze the interaction between scutellarin and core targets.

Results:

Two networks were established

including a disease-target network and a PPI network of scutellarin targets against AP and IS. Network analysis showed that 14 targets

namely

AKT1

VEGFA

JUN

ALB

MTOR

ESR1

MAPK8

HSP90AA1

NOS3

SERPINE1

FGA

FOXO3

and STAT1

might be the therapeutic targets of scutellarin in AP and IS. Among them

NOS3 and F2 were recognized as the core targets. Additionally

molecular docking simulation confirmed that scutellarin exhibited a relatively high potential for binding to the active sites of NOS3 and F2. Furthermore

enrichment analysis indicated that scutellarin might exert a therapeutic role in both AP and IS by regulating several important pathways

such as coagulation cascades

mitogen-activated protein kinase (MAPK) signaling pathway

phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway

Toll-like receptor signaling pathway

hypoxia inducible factor-1 (HIF-1) signaling pathway

forkhead box O (FoxO) signaling pathway

tumor necrosis factor (TNF) signaling pathway

adipocytokine signaling pathway

insulin signaling pathway

insulin resistance

and estrogen signaling pathway.

Conclusions:

The shared underlying mechanisms of scutellarin on AP and IS treatment might be strongly associated with its vasorelaxant

anticoagulant

anti-inflammatory

and antioxidative effects as well as its effect on improving lipid metabolism.

关键词

Keywords

scutellarinangina pectorisischemic strokenetwork pharmacology

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