Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial

khaton Zare Elmi Halimeh; Gholami Mohammad; Saki Mandana; Ebrahimzadeh Farzad

doi:10.1007/s11655-020-2727-1

Your Location：

Home >

Browse articles >

Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial

Original Article | Updated：2021-08-16

- Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial
- Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial
- Chinese Journal of Integrative Medicine 2021年27卷第1期页码：7-15
- Affiliations：
  
  1.Student Research Committee, Lorestan University of Medical Sciences, Khorramabad (6814993165), Iran
  2.School of Nursing and Midwifery, Lorestan University of Medical Sciences, Khorramabad (6814993165), Iran
  3.Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad (6814993165), Iran
  4.Department of Biostatistics and Epidemiology, School of Health and Nutrition,Lorestan University of Medical Sciences, Khorramabad(6814993165), Iran
- Author bio：
  
  Correspondence to: Dr. Mohammad Gholami, E-Mail:mohammad13565@yahoo.com
- Funds：
  
  the Research and Technology Deputy of Lorestan University of Medical Sciences
- DOI：10.1007/s11655-020-2727-1
  中图分类号：
- 纸质出版日期：2021-01-01，
  
  录用日期：2020-01-15
Scan for full text
khaton Zare Elmi Halimeh, Gholami Mohammad, Saki Mandana, 等. Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2021,27(1):7-15.

khaton Zare Elmi Halimeh, Gholami Mohammad, Saki Mandana, et al. Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2021,27(1):7-15.
khaton Zare Elmi Halimeh, Gholami Mohammad, Saki Mandana, 等. Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2021,27(1):7-15. DOI： 10.1007/s11655-020-2727-1.

khaton Zare Elmi Halimeh, Gholami Mohammad, Saki Mandana, et al. Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2021,27(1):7-15. DOI： 10.1007/s11655-020-2727-1.

摘要

Abstract

Objective:

To assess the effect of valerian root extract on the sleep quality of patients after coronary artery bypass graft (CABG) surgery.

Methods:

The patients who participated in this triple-blind clinical trial were selected by permuted block randomization. The participants were assigned to the valerian (

=36) and placebo (

=36) groups. The valerian group received 530 mg of valerian capsules for 30 nights after CABG surgery

and the placebo group received 530 mg of the placebo capsules containing wheat flour. The Pittsburgh Sleep Quality Index (PSQI)

the prothrombin time (PT) and partial thromboplastin time (PTT) were assessed on four occasions

including the baseline

the 3rd

14th and 30th days following intervention.

Results:

The odds ratio of worsened sleep quality significantly varied over time (the interaction of time and group) in the valerian group compared to the placebo group in various dimensions including total sleep quality (

=0.001)

sleep latency (

0.01)

sleep duration (

=0.020)

sleep efficiency (

=0.001) and daytime dysfunction (

=0.025). No significant difference was observed in the alterations of the odds ratio of PT in the two groups over time. (

=0.371).

Conclusion:

The consumption of oral valerian root extract over 30 nights could significantly improve the patients' sleep quality safely after CABG surgery.

关键词

Keywords

coronary artery bypass graftherbal medicinerandomized controlled trialsleep qualityvalerian

references

Dianatkhah M, Ghaeli P, Talasaz AH, Karimi A,Salehiomran A, Bina P, et al. Evaluating the potential effect of melatonin on the post-cardiac surgery sleep disorder. J Tehran Univ Heart Center 2015;10:122.

Caruana N, McKinley S, Elliott R, Gholizadeh L. Sleep Quality During and After Cardiothoracic Intensive Care and Psychological Health During Recovery. J Cardiovascular Nursing 2018;33:E40-E49.

Pröpper J, van Valen R, van Domburg RT, Brunott M,Bogers AJ. Quality of sleep at the ward after cardiothoracic surgery. Open J Nursing 2015;5:529.

Zhang L, Sha YS, Kong QQ, Woo JA-l, Miller AR, Li HW,et al. Factors that affect sleep quality: perceptions made by patients in the intensive care unit after thoracic surgery.Supportive Care Cancer 2013;21:2091-2096.

Nerbass FB, Feltrim MIZ, SAd Souza, Ykeda DS,Lorenzi-Filho G. Effects of massage therapy on sleep quality after coronary artery bypass graft surgery. Clinics 2010;65:1105-1110.

Fernandes NM, Nield LE, Popel N, Cantor WJ, Plante S,Goldman L, et al. Symptoms of disturbed sleep predict major adverse cardiac events after percutaneous coronary intervention. Canadian J Cardiol 2014;30:118-124.

Bagheri-Nesami M, Gorji MAH, Rezaie S, Pouresmail Z,Cherati JY. Effect of acupressure with valerian oil 2.5% on the quality and quantity of sleep in patients with acute coronary syndrome in a cardiac intensive care unit. J Tradit Complement Med 2015;5:241-247.

Cho EH, Lee MY, Hur MH. The effects of aromatherapy on intensive care unit patients' stress and sleep quality: A nonrandomised controlled trial. Evid Based Complement Altern Med 2017;2017.

Hajibagheri A, Babaii A, Adib-Hajbaghery M. Effect of Rosa damascene aromatherapy on sleep quality in cardiac patients: a randomized controlled trial. Complement Therap Clin Pract 2014;20:159-163.

Zhao K, Tian JF, Zhao C, Yuan F, Gao ZY, Li LZ, et al.Effectiveness of integrative medicine therapy on coronary artery disease prognosis: a real-world study. Chin J Integr Med 2019;25:9-15.

Nunes A, Sousa M. Use of valerian in anxiety and sleep disorders: what is the best evidence? Acta Medica Portug 2011;24:961-966.

Ahmadi M, Khalili H, Abbasian L, Ghaeli P. Effect of valerian in preventing neuropsychiatric adverse effects of efavirenz in HIV-positive patients: A pilot randomized, placebo-controlled clinical trial. Ann Pharmacother 2017;51:457-464.

Moghadam ZB, Rezaei E, Gholami RS, Kheirkhah M, Haghani H. The effect of Valerian root extract on the severity of pre menstrual syndrome symptoms. J Tradit Complement Med 2016;6:309-315.

Taavoni S, Ekbatani N, Kashaniyan M, Haghani H. Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial. Menopause 2011;18:951-955.

Regestein QR. Is there anything special about valerian? Menopause 2011;18:937-939.

Gorgoni M, D'Atri A, Lauri G, Rossini PM, Ferlazzo F,De Gennaro L. Is sleep essential for neural plasticity in humans, and how does it affect motor and cognitive recovery? Neur plast 2013;2013.

Taibi DM, Landis CA, Petry H, Vitiello MV. A systematic review of valerian as a sleep aid: safe but not effective.Sleep Med Reviews 2007;11:209-230.

Hassani S, Alipour A, Khezri HD, Firouzian A, Zeydi AE,Baradari AG, et al. Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial. Psychopharmacology 2015;232:843-850.

Mirghafourvand M, Charandabi SM-A, Hakimi S, Khodaie L,Galeshi M. Effect of orange peel essential oil on postpartum sleep quality: A randomized controlled clinical trial. Eur J Integr Med 2016;8:62-66.

Ramesha C, Nayak BS, Pai V, Patil N, George A, George LS, et al. Complementary therapies for patients undergoing cardiac surgery: an evidence based literature review.Manipal J Nursing Health Sci 2015;1:112-117.

Zhang Z. Model building strategy for logistic regression:purposeful selection. Annals Translational Med 2016;4:111.

Pisani M. Sleep in the intensive care unit: An oft-neglected key to health restoration. Heart Lung: J Acute Crit Care 2015;44:87.

Schmidleitner C, Arzt M, Tafelmeier M, Ripfel S, Fauser M, Weizenegger T, et al. Sleep-disordered breathing is associated with disturbed cardiac repolarization in patients with a coronary artery bypass graft surgery. Sleep Med 2018;42:13-20.

Jung HY, Yoo DY, Kim W, Nam SM, Kim JW, Choi JH, et al.Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites. BMC Complement Altern Med 2014;14:476.

Taavoni S, Haghani H. Valerian/lemon balm use for sleep disorders during menopause. Complement Therap Clin Practice 2013;19:193-196.

Becker A, Felgentreff F, Schröder H, Meier B, Brattström A. The anxiolytic effects of a Valerian extract is based on valerenic acid. BMC Complement Altern Med 2014;14:267.

Caudal D, Guinobert I, Lafoux A, Bardot V, Cotte C, Ripoche I, et al. Skeletal muscle relaxant effect of a standardized extract of Valeriana officinalis L. after acute administration in mice. J Tradit Complement Med 2018;8:335-340.

Zingone F, Siniscalchi M, Capone P, Tortora R, Andreozzi P,Capone E, et al. The quality of sleep in patients with coeliac disease. Alimentary Pharmacol Therap 2010;32:1031-1036.

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Efficacy of Biejiajian Pill on Intestinal Microbiota in Patients with Hepatitis B Cirrhosis/Liver Fibrosis: A Randomized Double-Blind Controlled Trial

Reyanning Mixture on Asymptomatic or Mild SARS-CoV-2 Infection in Children and Adolescents: A Randomized Controlled Trial