Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial

Yang OU; Sheng-jia SUN; Hai-ming SHI; Jian-feng LUO; Xin-ping LUO; Yun-zhi SHEN; Yu-fei CHEN; Wei-hu FAN; Hong-ying LIU; Wei SHEN

doi:10.1007/s11655-020-2728-0

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Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial

Original Article | Updated：2021-08-23

- Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial
- Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial
- Chinese Journal of Integrative Medicine 2020年26卷第9期页码：656-662
- Affiliations：
  
  1.Department of Cardiovascular Disease, Huashan Hospital, Fudan University, Shanghai (200040), China
  2.Department of Biostatistics, School of Public Health, Fudan University, Shanghai (200032), China
  3.Medical Department, Shanghai Green Valley Pharmaceutical Co., Ltd., Shanghai (201203), China
- Author bio：
  
  Correspondence to: Dr. SHEN Wei, E-mail:drshenwei@163.com
- Funds：
  
  the National Natural Science Foundation of China(81673701;81573710)
- DOI：10.1007/s11655-020-2728-0
  中图分类号：
- 纸质出版日期：2020-09-01，
  
  网络出版日期：2020-06-22，
  
  录用日期：2020-03-24
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Yang OU, Sheng-jia SUN, Hai-ming SHI, 等. Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(9):656-662.

Yang OU, Sheng-jia SUN, Hai-ming SHI, et al. Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(9):656-662.
Yang OU, Sheng-jia SUN, Hai-ming SHI, 等. Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(9):656-662. DOI： 10.1007/s11655-020-2728-0.

Yang OU, Sheng-jia SUN, Hai-ming SHI, et al. Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(9):656-662. DOI： 10.1007/s11655-020-2728-0.

摘要

Abstract

Objective:

To evaluate the protective effects of salvianolate on percutaneous coronary intervention (PCI) related myocardial injury or myocardial infarction after elective PCI in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients.

Methods:

A total of 149 patients with NSTE-ACS who underwent elective PCI were enrolled. The patients were randomly allocated in a 1:1 ratio to the salvianolate group (74 cases) or the control group (75 cases). After exclusion criteria of coronary angiography

60 patients with PCI therapy remained in the salvianolate group and 68 in the control group. The incidence and the severity of PCI related myocardial injury or myocardial infarction

in addition to major adverse cardiac events (MACEs) during 1 year follow-up after PCI were studied between the two groups. Multivariate logistic regression analysis was used to determine the independent factors for PCI related myocardial injury or myocardial infarction after elective PCI.

Results:

Compared with the control group

salvianolate treatment reduced the incidence of PCI related severe myocardial injury or myocardial infarction (11.7% vs. 26.5%

=0.035). The rate of MACEs or all-cause death within 1 month or 1 year after the procedure was not significantly different between the two groups.

Conclusions:

Periprocedural treatment with salvianolate reduces the incidence of PCI related severe myocardial injury or myocardial infarction

although it does not influence clinical prognosis. [Chinese clinical trial registry: ChiCTR1800016992]

关键词

Keywords

myocardial infarctionacute coronary syndromepercutaneous coronary interventionsalvianolate

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