<italic style="font-style: italic">Panax Notoginseng Saponins</italic> Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NFκB Pathway

Ru-feng MA; Guang CHEN; Hong-zheng LI; Yun ZHANG; Yong-mei LIU; Hao-qiang HE; Chen-yue LIU; Zi-cong XIE; Zhen-peng ZHANG; Jie WANG

doi:10.1007/s11655-020-2856-6

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Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NFκB Pathway

Original Article | Updated：2021-08-23

- Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NFκB Pathway
- Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NFκB Pathway
- Chinese Journal of Integrative Medicine 2020年26卷第12期页码：897-904
- Affiliations：
  
  1.Graduate School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing (100029), China
  2.Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing (100053), China
- Author bio：
  
  Correspondence to: Prof. WANG Jie, E-mail:wangjie0103@126.com
- Funds：
  
  the National Significant New Drugs Development(2013ZX09301307);National Natural Science Foundation of China(81774168)
- DOI：10.1007/s11655-020-2856-6
  中图分类号：
- 纸质出版日期：2020-12-01，
  
  录用日期：2020-04-20
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Ru-feng MA, Guang CHEN, Hong-zheng LI, 等. Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NFκB Pathway[J]. Chinese Journal of Integrative Medicine, 2020,26(12):897-904.

Ru-feng MA, Guang CHEN, Hong-zheng LI, et al. Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NFκB Pathway[J]. Chinese Journal of Integrative Medicine, 2020,26(12):897-904.
Ru-feng MA, Guang CHEN, Hong-zheng LI, 等. Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NFκB Pathway[J]. Chinese Journal of Integrative Medicine, 2020,26(12):897-904. DOI： 10.1007/s11655-020-2856-6.

Ru-feng MA, Guang CHEN, Hong-zheng LI, et al. Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NFκB Pathway[J]. Chinese Journal of Integrative Medicine, 2020,26(12):897-904. DOI： 10.1007/s11655-020-2856-6.

摘要

Abstract

Objective:

To explore whether

Panax notoginseng saponins

(PNS) exhibits heart protective effect in myocardial infarction (MI) rats and to identify the potential signaling pathways involved.

Methods:

MI rats induced by ligating the left anterior descending (LAD) coronary artery were assigned to sham coronary artery ligation or coronary artery ligation. Totally 36 Sprague-Dawley rats were randomly divided into sham group (distilled water

=9)

MI group (distilled water

=9)

PNS group (PNS

40 mg/kg daily

=9) and fosinopril group (FIP

1.2 mg/kg daily

=9) according to a random number table. The left ventricular morphology and function were conducted by echocardiography. Histological alterations were evaluated by the stainings of HE and Masson. The serum levels of C reactive protein (CRP)

tumor necrosis factor α (TNF-α)

growth differentiation factor-15 (GDF-15) and the ratio of metalloproteinase-9 (MMP-9) and tissue inhibitor of MMP-9 (TIMP-1) were determined by ELISA. The levels of activating transcription factor 3 (ATF3)

mitogen-activated protein kinase kinase 3 (MAP2K3)

p38 mitogen-activated protein kinase (p38 MAPK)

phosphorylation of p38 MAPK (p-p38 MAPK)

transforming growth factor-β (TGF-β1)

collagen Ⅰ

nuclear factor kappa B p65 (NFκB p65)

phosphorylation of NFκB p65 (p-NFκB p65)

and phosphorylation of inhibitory kappa Bα (p-Iκ Bα) in hearts were measured by Western blot and immunohistochemical staining

respectively.

Results:

PNS improved cardiac function and fibrosis in MI rats (

0.05). The serum levels of CRP

TNF-α

GDF-15 and the ratio of MMP9/TIMP1 were reversed by PNS in MI rats. The expressions of TGF-β1

collagen Ⅰ

MAP2K3

p38 MAPK

p-p38 MAPK

NFκB p65

p-NFκB p65

and p-IκBα were down-regulated

while ATF3 increased with the treatment of PNS (

0.05).

Conclusions:

PNS may improve cardiac function and fibrosis in MI rats via regulating ATF3/MAP2K3/p38 MAPK and NFκB signaling pathways. These results suggest the potential of PNS in preventing the development of ventricular remodeling in MI rats.

关键词

Keywords

Panax notoginseng saponinsmyocardial infarctionventricular remodeling inflammation

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Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NFκB Pathway

Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NFκB Pathway

DOI：10.1007/s11655-020-2856-6

摘要

Abstract

关键词

Keywords

references