Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis

Jie-hua DENG; Ji-hong LI; Yi-le ZHAO; Gang-sheng WANG

doi:10.1007/s11655-020-3075-x

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Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis

Original Article | Updated：2021-08-16

- Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis
- Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis
- Chinese Journal of Integrative Medicine 2021年27卷第4期页码：286-290
- Affiliations：
  
  1.Department of Dermatology, the Second Hospital of Hebei Medical University, Shijiazhuang (050000), China
  2.Clinical Lab, the Second Hospital of Hebei Medical University, Shijiazhuang (050000), China
  3.Department of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang(050000), China
  4.Department of Scientific Research, the Second Hospital of Hebei Medical University, Shijiazhuang(050000), China
- Author bio：
  
  Correspondence to: Prof. WANG Gang-sheng, E-mail:djh092@163.com
- Funds：
  
  the Natural Science Foundation of Hebei Province
- DOI：10.1007/s11655-020-3075-x
  中图分类号：
- 纸质出版日期：2021-04-01，
  
  网络出版日期：2020-05-15，
  
  录用日期：2018-03-30
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Jie-hua DENG, Ji-hong LI, Yi-le ZHAO, 等. Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis[J]. Chinese Journal of Integrative Medicine, 2021,27(4):286-290.

Jie-hua DENG, Ji-hong LI, Yi-le ZHAO, et al. Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis[J]. Chinese Journal of Integrative Medicine, 2021,27(4):286-290.
Jie-hua DENG, Ji-hong LI, Yi-le ZHAO, 等. Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis[J]. Chinese Journal of Integrative Medicine, 2021,27(4):286-290. DOI： 10.1007/s11655-020-3075-x.

Jie-hua DENG, Ji-hong LI, Yi-le ZHAO, et al. Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis[J]. Chinese Journal of Integrative Medicine, 2021,27(4):286-290. DOI： 10.1007/s11655-020-3075-x.

摘要

Abstract

Objective:

To evaluate the effect and safety of cinnamaldehyde on immunosuppressed mice with invasive pulmonary candidiasis.

Methods:

An immunosuppressed BALB/c mouse model was established by intraperitoneal administration of cyclophosphamide (200 mg/kg) once daily for 2 days. The immunosuppressed mouse with invasive pulmonary candidiasis model was further established by nasal perfusion of

Candida albicans

suspension. In the cinnamaldehyde treatment group

immunosuppressed mice with invasive pulmonary candidiasis were orally given cinnamaldehyde 240 mg/(kg•d) for 14 consecutive days. Fluconazole and 0.9% saline were used as the positive and negative controls

respectively. The mice in the cinnamaldehyde safety evaluation group were orally administered cinnamaldehyde 480 mg/(kg•d) for 42 days to observe the safety of the drug. Microscopic identification

fungal culture

histopathological examination

and (1

3)-beta-D-glucans detection were conducted to analyze the effect of cinnamaldehyde on

C. albicans

Results:

The fungal clearance rate in the cinnamaldehyde treatment group was higher than that in the fluconazole control group (80.00% vs. 56.67%

0.05). The level of (1

3)-β-D-glucan in the cinnamaldehyde treatment group was lower than that in the fluconazole positive control group (1160.62±89.65 pg/mL vs. 4285.87±215.62 pg/mL

0.05). The survival rate of mice in the cinnamaldehyde safety evaluation group was 100%

and no significant pathological changes of kidney

lung and liver were observed.

Conclusions:

Cinnamaldehyde was effective and safe in treating immunosuppressed BALB/c mice with invasive pulmonary candidiasis. It would be a potentially novel drug for anti-candidiasis infection.

关键词

Keywords

cinnamaldehydeCandida albicansinvasive pulmonary infectionChinese medicinesafety

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