Yogurt Intake Reduces All-Cause and Cardiovascular Disease Mortality: A Meta-Analysis of Eight Prospective Cohort Studies

Xiang GAO; Hai-yi JIA; Guo-chong CHEN; Cheng-yue LI; Mo HAO

doi:10.1007/s11655-020-3085-8

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Yogurt Intake Reduces All-Cause and Cardiovascular Disease Mortality: A Meta-Analysis of Eight Prospective Cohort Studies

Evidence-Based Integrative Medicine | Updated：2021-08-23

- Yogurt Intake Reduces All-Cause and Cardiovascular Disease Mortality: A Meta-Analysis of Eight Prospective Cohort Studies
- Yogurt Intake Reduces All-Cause and Cardiovascular Disease Mortality: A Meta-Analysis of Eight Prospective Cohort Studies
- Chinese Journal of Integrative Medicine 2020年26卷第6期页码：462-468
- Affiliations：
  
  1.Research Institute of Health Development Strategies, Fudan University, Shanghai (200032), China
  2.School of Public Health, Xuzhou Medical University, Xuzhou (221004), China
  3.School of Public Health and Management, Weifang Medical University, Weifang, Shandong Province (261053), China
  4.Department of Epidemiologyand Population Health, Albert Einstein College of Medicine, NY (10461), USA
- Author bio：
  
  Correspondence to: Prof. HAO Mo, E-mail:haomo03@aliyun.com
- Funds：
  
  the Shanghai Three-Year Action Plan for Strengthening Public Health System Construction (2015–2017)(GWIV-32)
- DOI：10.1007/s11655-020-3085-8
  中图分类号：
- 纸质出版日期：2020-06-01，
  
  网络出版日期：2020-01-22，
  
  录用日期：2019-10-21
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Xiang GAO, Hai-yi JIA, Guo-chong CHEN, 等. Yogurt Intake Reduces All-Cause and Cardiovascular Disease Mortality: A Meta-Analysis of Eight Prospective Cohort Studies[J]. Chinese Journal of Integrative Medicine, 2020,26(6):462-468.

Xiang GAO, Hai-yi JIA, Guo-chong CHEN, et al. Yogurt Intake Reduces All-Cause and Cardiovascular Disease Mortality: A Meta-Analysis of Eight Prospective Cohort Studies[J]. Chinese Journal of Integrative Medicine, 2020,26(6):462-468.
Xiang GAO, Hai-yi JIA, Guo-chong CHEN, 等. Yogurt Intake Reduces All-Cause and Cardiovascular Disease Mortality: A Meta-Analysis of Eight Prospective Cohort Studies[J]. Chinese Journal of Integrative Medicine, 2020,26(6):462-468. DOI： 10.1007/s11655-020-3085-8.

Xiang GAO, Hai-yi JIA, Guo-chong CHEN, et al. Yogurt Intake Reduces All-Cause and Cardiovascular Disease Mortality: A Meta-Analysis of Eight Prospective Cohort Studies[J]. Chinese Journal of Integrative Medicine, 2020,26(6):462-468. DOI： 10.1007/s11655-020-3085-8.

摘要

Abstract

Objective:

To assess the relationship between yogurt intake and mortality risk from prospective cohort studies.

Methods:

The PubMed

EMBASE

and Web of Science databases were searched for all records related to yogurt intake and mortality risk [all-cause or cardiovascular disease (CVD) or cancer mortality] before October 1

2018. The Newcastle-Ottawa Quality Scale was used to estimate the quality of all eligible articles. The results of the highest and lowest categories of yogurt intake in each study were collected and the effect size was pooled using a random effects model. The dose-response analysis was calculated using the generalized least squares trend estimation model.

Results:

Eight eligible cohort studies were included in this meta-analysis. There were 235

676 participants in the 8 studies

and the number of deaths was 14

831. Compared with the lowest category

the highest category of yogurt intake was not significantly related with allcause mortality [hazard ratio (HR)=0.93; 95% confidence interval (CI): 0.85

1.01]

CVD mortality (HR=0.92; 95% CI: 0.81

1.03) and cancer mortality (HR=0.97; 95% CI: 0.83

1.12). These studies were homogenous

since the homogeneity test showed that

was 28.7%

15.1% and 11.8%

respectively. However

yogurt intake ≥200 g/d was significantly associated with a lower all-cause mortality (HR=0.88; 95% CI: 0.80

0.96) and CVD mortality (HR=0.87; 95% CI: 0.77

0.99) in the subgroup analysis. The dose-response analysis showed that yogurt intake of 200 g/d was inversely associated with all-cause mortality (

=0.041

HR=0.95

95% CI: 0.92

1.00) and CVD mortality (

=0.009

HR=0.92

95% CI: 0.86

0.98)

and all of which were linear relationship (

0.05).

Conclusions:

This review provided the evidence regarding yogurt intake can reduce all-cause and CVD mortality. Although some positive findings were identified

more high-quality cohort studies and randomized controlled trials are warranted on a possible protective effect of yoghurt on health.

关键词

Keywords

yogurtmortalitycardiovascular diseasecancermeta-analysis

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