Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis: A Randomized Controlled Trial

You-jin LI; Ming ZONG; Li-feng DING; Xiao-qing RUI; Bei-yin MA; Li-ping QIN

doi:10.1007/s11655-020-3099-2

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Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis: A Randomized Controlled Trial

Acupuncture Research | Updated：2021-08-23

- Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis: A Randomized Controlled Trial
- Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis: A Randomized Controlled Trial
- Chinese Journal of Integrative Medicine 2020年26卷第11期页码：845-852
- Affiliations：
  
  1.Department of Otorhinolaryngology-Head and Neck Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai (200127), China
  2.Department of Clinical Laboratory, Shanghai East Hospital, School of Medicine, Tong Ji University, Shanghai (200120), China
  3.Department of Chinese Medicine, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai (200127), China
  4.Department of Medical Genetics and Molecular Diagnostic Laboratory, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai (200127), China
  5.Department of Chinese Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai (200090), China
- Author bio：
  
  Correspondence to: Dr. QIN Li-ping, E-mail:bbb___123@126.com
- Funds：
  
  the Medicine Leading Science and Technology Project of Shanghai Municipal Science and Technology Commission(15401933800)
- DOI：10.1007/s11655-020-3099-2
  中图分类号：
- 纸质出版日期：2020-11-01，
  
  网络出版日期：2020-09-01，
  
  录用日期：2019-02-13
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You-jin LI, Ming ZONG, Li-feng DING, 等. Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(11):845-852.

You-jin LI, Ming ZONG, Li-feng DING, et al. Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(11):845-852.
You-jin LI, Ming ZONG, Li-feng DING, 等. Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(11):845-852. DOI： 10.1007/s11655-020-3099-2.

You-jin LI, Ming ZONG, Li-feng DING, et al. Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(11):845-852. DOI： 10.1007/s11655-020-3099-2.

摘要

Abstract

Objective:

To evaluate the efficacy of Chinese medicine acupoint application (CMAA) combined with Western medicine for perennial allergic rhinitis (PAR) in children.

Methods:

In this prospective

parallel

randomized

placebo-controlled and single-blind trial from August to September

2017

180 children with PAR were randomly assigned to an integrative group (CMAA and Montelukast)

CMAA group (CMAA and placebo tablet)

or Montelukast group (placebo CMAA and Montelukast). Participants were applied with CMAA for 6 sessions over 2 weeks

and/or Montelukast Chewable Tablet orally once daily for 12 weeks. The changes in severity of symptoms were measured by Visual Analog Scale (VAS) and rhinitis control assessment test (RCAT) at 0

4 and 12 weeks of treatment. Blood samples were collected for serum interleukin-4

interferon gamma γ and T helper type 1 (Th1)/Th2 flow cytometric analysis at the time points of 0

4 and 12 weeks.

Results:

Eight cases dropped out from the trial

3 in the integrative group

2 in the CMAA group and 3 in the Montelukast group. The VAS scores decreased significantly while the RCAT scores increased significantly in all three groups at 4 and 12 weeks compared with baseline (

0.01 or

0.05). The VAS scores were significantly lower while the RCAT scores were significantly higher in the integrative and CMAA groups than the Montelukast group at 2 and 4 weeks (

0.01 or

0.05). At 2

4 and 12 weeks

the scores of nasal congestion

sneezing

sleep problem

and rhinitis symptom control in the integrative and CMAA groups increased significantly compared with baseline (

0.01 or

0.05). The least percentages of Th2 and the most alleviated Th2 shift (highest Th1/Th2) were observed in the integrative group at 12 weeks compared with the other two groups (

0.05).

Conclusion:

The combination of CMAA with Montelukast might be more effective and appropriate than either option alone for children with PAR. (Registered at Chinese Clinical Trial Register

registration No. ChiCTR-IOR-17012434)

关键词

Keywords

allergic rhinitisChinese medicineacupoint applicationMontelukastinterferon gamma/ interleukin-4T helper type 1/T helper type 2

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