Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats

Hua-bin ZHANG; Xian-kun TU; Shi-wei SONG; Ri-sheng LIANG; Song-sheng SHI

doi:10.1007/s11655-020-3183-7

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Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats

Original Article | Updated：2021-08-23

- Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats
- Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats
- Chinese Journal of Integrative Medicine 2020年26卷第7期页码：510-518
- Affiliations：
  
  Department of Neurosurgery, Fujian Medical University Union Hospital, Neurosurgery Research Institute of Fujian Province, Fuzhou (350001), China
- Author bio：
  
  Correspondence to: Prof. TU Xian-kun, E-mail:unionnstu@hotmail.com
- Funds：
  
  the Project of Medical Innovation of Health and Family Planning Commision of Fujian Province of China(2016-CX-18);the Natural Science Foundation of Fujian Province of China(2017J01204);the Key Young Talents Cultivation Project of Health and Family Planning Commision of Fujian Province of China(2016-ZQN-28);the Excellent Youth Scientific Research Personnel Cultivation Program of Fujian Province's High School(2016B026);the Clinical Key Subject (Neurosurgery) Foundation of Fujian Medical University;the Key Department (Neurosurgery) Foundation from Fujian Medical University Union Hospital, China
- DOI：10.1007/s11655-020-3183-7
  中图分类号：
- 纸质出版日期：2020-07-01，
  
  网络出版日期：2020-01-23，
  
  录用日期：2018-10-31
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Hua-bin ZHANG, Xian-kun TU, Shi-wei SONG, 等. Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats[J]. Chinese Journal of Integrative Medicine, 2020,26(7):510-518.

Hua-bin ZHANG, Xian-kun TU, Shi-wei SONG, et al. Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats[J]. Chinese Journal of Integrative Medicine, 2020,26(7):510-518.
Hua-bin ZHANG, Xian-kun TU, Shi-wei SONG, 等. Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats[J]. Chinese Journal of Integrative Medicine, 2020,26(7):510-518. DOI： 10.1007/s11655-020-3183-7.

Hua-bin ZHANG, Xian-kun TU, Shi-wei SONG, et al. Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats[J]. Chinese Journal of Integrative Medicine, 2020,26(7):510-518. DOI： 10.1007/s11655-020-3183-7.

摘要

Abstract

Objective:

To evaluate the effect of baicalin on subarachnoid hemorrhage (SAH) in rats and explore the potential mechanisms.

Methods:

Sprague-Dawley rats underwent experimental SAH and received treatment with baicalin at 10 or 50 mg/kg after 2 and 12 h of SAH. Neurological scores

brain water content

Evans-blue extravasation

and levels of glutathione peroxidase (GSH-Px)

superoxide dismutase (SOD)

myeloperoxidase (MPO)

and malondialdehyde (MDA) were measured 24 h after SAH. Expression of nuclear factor erythroid-related factor 2 (Nrf2)

NAD(P)H: quinone oxidoreductase 1 (NQO1)

matrix metalloproteinase-9 (MMP-9)

aquaporin 4 (AQP4)

occludin

and zonulaoccludens-1 (ZO-1) were detected in the brain by Western blot. Heme oxygenase-1 (HO-1) was detected by quantitative polymerase chain reaction

and tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were assessed by enzyme-linked immunosorbent assay.

Results:

Baicalin attenuated EBI 24 h after SAH in rats (

0.05). Baicalin elevated neurological scores

GSH-Px

SOD

and increased the expression of Nrf2

NQO1

HO-1

occludin

and ZO-1 in SAH rats (

0.05 or

0.01). Baicalin reduced MPO

MDA

and the expression of MMP-9

AQP4

TNF-α

and IL-1β (

0.05 or

0.01).

Conclusion:

Baicalin reduced SAH-induced EBI

partially via activation of the Nrf2/HO-1 pathway and inhibition of MMP-9 and AQP4.

关键词

Keywords

aquaporin 4baicalinChinese medicineearly brain injurymatrix metalloproteinase-9subarachnoid hemorrhage

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