Huayu Pill (化瘀丸) Promotes Fluorescent Doxorubicin Delivery to Tumors in Mouse Model of Lung Cancer

Lei GAO; Cai-xia HAO; Gan-lin ZHANG; Ke-xin CAO; Ming-wei YU; Qi-wei LI; Xue-man MA; Guo-wang YANG; Xiao-min WANG

doi:10.1007/s11655-020-3191-7

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Huayu Pill (化瘀丸) Promotes Fluorescent Doxorubicin Delivery to Tumors in Mouse Model of Lung Cancer

Original Article | Updated：2021-09-01

- Huayu Pill (化瘀丸) Promotes Fluorescent Doxorubicin Delivery to Tumors in Mouse Model of Lung Cancer
- Huayu Pill (化瘀丸) Promotes Fluorescent Doxorubicin Delivery to Tumors in Mouse Model of Lung Cancer
- Chinese Journal of Integrative Medicine 2021年27卷第7期页码：514-519
- Affiliations：
  
  1.Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing (100010), China
  2.School of Traditional Chinese Medicine. Beijing University of Chinese Medicine, Beijing (100029), China
- Author bio：
  
  Prof. WANG Xiao-min, E-mail:wangxiaomin_bhtcm@126.com
- Funds：
  
  the National Natural Science Foundation of China(81603579;81873111;81673924;81774039)
- DOI：10.1007/s11655-020-3191-7
  中图分类号：
- 纸质出版日期：2021-07-01，
  
  网络出版日期：2020-03-07，
  
  录用日期：2020-01-10
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Lei GAO, Cai-xia HAO, Gan-lin ZHANG, 等. Huayu Pill (化瘀丸) Promotes Fluorescent Doxorubicin Delivery to Tumors in Mouse Model of Lung Cancer[J]. Chinese Journal of Integrative Medicine, 2021,27(7):514-519.

Lei GAO, Cai-xia HAO, Gan-lin ZHANG, et al. Huayu Pill (化瘀丸) Promotes Fluorescent Doxorubicin Delivery to Tumors in Mouse Model of Lung Cancer[J]. Chinese Journal of Integrative Medicine, 2021,27(7):514-519.
Lei GAO, Cai-xia HAO, Gan-lin ZHANG, 等. Huayu Pill (化瘀丸) Promotes Fluorescent Doxorubicin Delivery to Tumors in Mouse Model of Lung Cancer[J]. Chinese Journal of Integrative Medicine, 2021,27(7):514-519. DOI： 10.1007/s11655-020-3191-7.

Lei GAO, Cai-xia HAO, Gan-lin ZHANG, et al. Huayu Pill (化瘀丸) Promotes Fluorescent Doxorubicin Delivery to Tumors in Mouse Model of Lung Cancer[J]. Chinese Journal of Integrative Medicine, 2021,27(7):514-519. DOI： 10.1007/s11655-020-3191-7.

摘要

Abstract

Objective:

To study the effect and mechanism of Huayu Wan (化瘀丸

HYW) in combination of chemotherapy of tumor treatment.

Methods:

HYW serum was added in Lewis cells to assess its impact on fluorescent doxorubicin delivery

in vitro

. Then

Lewis tumor cells was implanted in C57BL/6 mice via xenograft transplantation. Tumor growth was measured and signal intensity corresponding to blood flow was assessed by laser doppler perfusion imaging (LDPI). Finally

the effect of HYW on the efficacy of doxorubicin was studied.

Results:

HYW can improve the transfer of fluorescent doxorubicin into cells. The blood flow signal in the tumor tissues of the HYW group was higher than that of the control group (

0.01). Furthermore

HYW improved drug delivery of doxorubicin to tumor tissues

and this activity was associated with HYW-induced microvascular proliferation (

0.01).

Conclusions:

HYW can promote microangiogenesis and increase blood supply in tumor tissues

which in turn may increase the risk of metastasis. At the same time

HYW increases drug delivery and improves the efficacy of chemotherapy drugs through vascular proliferation. Therefore

rational judgment must be exercised when considering applying HYW to an antitumor regimen.

关键词

Keywords

Huayu WanChinese medicinefluorescent doxorubicindrug delivery

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