Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment: A Randomized Controlled Trial

Fu WANG; Qing-he GAO; Qiang GENG; Qiang HAN; Jia-you ZHAO; Guo-jin YU; Ji-wei ZHANG; Bin YAN; Jun GUO; Chun-sheng SONG

doi:10.1007/s11655-020-3211-7

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Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment: A Randomized Controlled Trial

Clinical Experience | Updated：2021-08-23

- Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment: A Randomized Controlled Trial
- Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment: A Randomized Controlled Trial
- Chinese Journal of Integrative Medicine 2020年26卷第2期页码：146-151
- Affiliations：
  
  1.Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
  2.Department of Andrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin (300193), China
  3.Department of Andrology, Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing (100010), China
  4.Graduate School, China Academy of Chinese Medical Sciences, Beijing (100700), China
- Author bio：
  
  Correspondence to: Prof. SONG Chun-sheng, E-mail:sonchun@vip.163.com
- Funds：
  
  the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ070855)
- DOI：10.1007/s11655-020-3211-7
  中图分类号：
- 纸质出版日期：2020-02-01，
  
  录用日期：2019-05-30
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Fu WANG, Qing-he GAO, Qiang GENG, 等. Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(2):146-151.

Fu WANG, Qing-he GAO, Qiang GENG, et al. Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(2):146-151.
Fu WANG, Qing-he GAO, Qiang GENG, 等. Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(2):146-151. DOI： 10.1007/s11655-020-3211-7.

Fu WANG, Qing-he GAO, Qiang GENG, et al. Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment: A Randomized Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(2):146-151. DOI： 10.1007/s11655-020-3211-7.

摘要

Abstract

Objective:

To evaluate the clinical effectiveness and safety of the Chinese medicine (CM) Qixiong Zhongzi Decoction (芪芎种子汤

QZD) in the treatment of patients with idiopathic asthenozoospermia.

Methods:

A total number of 66 patients with idiopathic asthenozoospermia were included and randomly divided into treatment and control groups by SAS-generated code from January 2015 to August 2016

33 patients in each group. Patients in the treatment group were administered with 150 mL of QZD twice a day

whereas those in the control group were given 1 g of levocarnitine oral liquid twice a day. The two groups received the indicated medication for 12 weeks and were then followed up for 4 weeks. The primary outcome was sperm motility

and the secondary therapeutic indices were sperm volume

density

pregnancy probability

and CM syndrome score. The comparison between groups was carried out at 4

8 and 12 weeks

respectively. The safety was determined before and after treatment.

Results:

(1) Drop-off: 5 cases (7.58%) were lost after treatment (2 from the treatment group and 3 from the control group). (2) Primary outcomes: after 8- and 12-week treatment

the progressive sperms in the two groups were significantly higher than the baseline (all

0.05); however

the treatment group showed greater improvement compared with the control group at 12-week treatment (22.7%±9.0% vs. 14.1%±8.8%

0.05). The increasement of non-progressive grade sperms at both groups was observed at 8- and 12-week treatment with statistical difference (all

0.05)

however

the treatment group showed remarkable improvement compared with the control group at 12-week treatment (38.7%±14.1% vs. 26.2%±15.4%

0.05). (3) Secondary outcomes: no significant statistical differences were found in semen volume and density (4

and 12-week treatment) and pregnancy probability of patients' wives (12-week treatment) between two groups (all

0.05)

however

the CM syndrome score of the treatment group significantly declined compared with baseline level at each time points (all

0.05). (4) Safety: no obvious side reactions were found during the treatment in both groups.

Conclusions:

QZD could improve the progressive and non-progressive grade sperm in the treatment of idiopathic asthenozoospermia. It is safe with no obvious side effects.

关键词

Keywords

idiopathic asthenozoospermiaQixiong Zhongzi DecoctionChinese medicinerandom controlled trial

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