Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial

Hamide Khorram Pazhouh; Seyyd Musa al-Reza Hosseini; Ali Taghipour; Shokouhsadat Hamedi; Mohammadreza Noras

doi:10.1007/s11655-020-3267-4

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Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial

Original Article | Updated：2021-08-23

- Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial
- Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial
- Chinese Journal of Integrative Medicine 2020年26卷第10期页码：729-735
- Affiliations：
  
  1.Persian Medicine, Faculty of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad (9177899191), Iran
  2.Department of Gastroenterology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad (91776699199), Iran
  3.Faculty of Health, Mashhad University of Medical Sciences, Mashhad (9137673119), Iran
  4.Department of Persian Pharmacy, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad (9177899191), Iran
  5.Persian Traditional Medicine, Faculty of Persian Traditional and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad (9177899191), Iran
- Author bio：
  
  Correspondence to: Assistant Prof. Mohammadreza Noras, E-mail:NorasMR@mums.ac.ir
- Funds：
  
  School of Persian and Complementary Medicine, Mashhad University of Medical Sciences
- DOI：10.1007/s11655-020-3267-4
  中图分类号：
- 纸质出版日期：2020-10-01，
  
  网络出版日期：2020-07-04，
  
  录用日期：2019-08-29
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Hamide Khorram Pazhouh, Seyyd Musa al-Reza Hosseini, Ali Taghipour, 等. Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(10):729-735.

Hamide Khorram Pazhouh, Seyyd Musa al-Reza Hosseini, Ali Taghipour, et al. Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(10):729-735.
Hamide Khorram Pazhouh, Seyyd Musa al-Reza Hosseini, Ali Taghipour, 等. Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(10):729-735. DOI： 10.1007/s11655-020-3267-4.

Hamide Khorram Pazhouh, Seyyd Musa al-Reza Hosseini, Ali Taghipour, et al. Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2020,26(10):729-735. DOI： 10.1007/s11655-020-3267-4.

摘要

Abstract

Objective:

To evaluate the efficacy and safety of administration of the formulated Persian herbal syrup on improving the symptoms of patients with constipation-predominant irritable bowel syndrome (IBS-C).

Methods:

This study was conducted in 70 patients with IBS-C

who were recruited from 3 medical centers in Mashhad

Iran

from November 2017 to August 2018. Seventy patients were randomly assigned to 2 groups including treatment and placebo groups by block randomization

35 cases in each group. Patients in the treatment group received 15 mL of anti-IBS syrup

thrice daily for 6 weeks and followed up for 4 weeks. Placebo syrup was also prepared through similar instruction

BP syrup without plant extract was used. Primary outcome induding IBS Symptom Severity Scale (IBS-SSS) questionnaire and secondary outcomes in terms of Hospital Anxiety and Depression (HADS) questionnaires

the Bristol Stool Form Scale (BSFS) were completed and evaluated at weeks 6 and 10

respectively. Safety indices were collected at the end of the treatment and Common Terminology Criteria for Adverse Events v4.0 (CTCAE) was used to evaluate the adverse events.

Results:

The response to treatment was 84.4% (27/32) in the treatment group and 46.4% (13/28) in the placebo group

respectively (

=0.002). Compared with pre-treatment

a significant decrease was found on the IBS-SSS and BSFS scores after 6-week intervention in both groups (

0.001). Moreover

IBS-SSS and BSFS scores in the treatment group were lower than the placebo group after the intervention (

=0.041). There was no significant difference in the anxiety and depression scores after treatment in both groups (

0.05). Side effects reported in the treatment group included 2 cases of headache during the first week of the onset of the treatment

1 case of drowsiness

1 case of increase in menstrual bleeding

which did not result in discontinuation of the treatment. In the placebo group

1 case of exacerbation of the disease was reported.

Conclusions:

Anti-IBS syrup significantly reduced the severity of IBS symptoms compared to placebo. However

there was a need for further investigation regarding the anxiety and depression scores. (Registration No. IRCT2017061034446N1).

关键词

Keywords

irritable bowel syndromeherbal medicinePersian medicinecomplementary medicinefunctional digestive disordersrandomized controlled trial

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