Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study

Qun ZHANG; Yu-xin LI; Yao LIU; Yi-xin HOU; Bing-bing ZHU; Yun-yi HUANG; Ke SHI; Xian-bo WANG

doi:10.1007/s11655-020-3272-7

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Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study

Original Article | Updated：2021-09-01

- Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study
- Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study
- Chinese Journal of Integrative Medicine 2021年27卷第8期页码：589-596
- Affiliations：
  
  1.Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing(100015), China
  2.Department of Gastroenterology, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing(100029), China
  3.Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing(100700), China
- Author bio：
  
  Dr. WANG Xian-bo, E-mail:wangxb@ccmu.edu.cn
- Funds：
  
  the Capital Health Development Research Project(2018-1-2172);Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding(ZYLX201707)
- DOI：10.1007/s11655-020-3272-7
  中图分类号：
- 纸质出版日期：2021-08-01，
  
  网络出版日期：2020-09-01，
  
  录用日期：2020-05-20
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Qun ZHANG, Yu-xin LI, Yao LIU, 等. Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study[J]. Chinese Journal of Integrative Medicine, 2021,27(8):589-596.

Qun ZHANG, Yu-xin LI, Yao LIU, et al. Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study[J]. Chinese Journal of Integrative Medicine, 2021,27(8):589-596.
Qun ZHANG, Yu-xin LI, Yao LIU, 等. Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study[J]. Chinese Journal of Integrative Medicine, 2021,27(8):589-596. DOI： 10.1007/s11655-020-3272-7.

Qun ZHANG, Yu-xin LI, Yao LIU, et al. Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study[J]. Chinese Journal of Integrative Medicine, 2021,27(8):589-596. DOI： 10.1007/s11655-020-3272-7.

摘要

Abstract

Objective:

To assess whether adjuvant Chinese patent medicines (CPMs) to standard treatment could reduce recurrent bleeding after variceal bleeding in cirrhotic patients.

Methods:

This study retrospectively collected 555 consecutive patients who recovered from variceal bleeding. A population-based cohort study was established depending on if adjuvant CPMs were administered to prevent rebleeding. A total of 139 patients who had taken ≥28 cumulative defined daily doses (cDDDs) of CPMs were included in the CPMs cohort

and 416 patients who used <28 cDDDs of CPMs were enrolled in the non-CPMs cohort. On evaluation of rebleeding incidence

1: 2 propensity score matched was used to estimate for reducing bias. Patients were followed for at least 12 months. The end-point of this study was clinically significant esophagogastric variceal rebleeding.

Results:

Following multivariate analysis

CPMs therapy was an independent factor for variceal rebleeding [adjusted hazard ratio (AHR)=0.657; 95% confidence interval=0.497–0.868;

=0.003]. After the 1:2 propensity score matching

a significant reduction (23.5%) in the incidence of variceal rebleeding in patients was observed

from 58.3% in the non-CPMs cohort to 44.6% in the CPMs cohort (modified log-rank test

=0.002) within a year. The AHRs for rebleeding were 0.928

0.553

and 0.105

for 28–90 cDDDs

91–180 cDDDs

and

180 cDDDs of CPMs

respectively. The median rebleeding interval in the CPMs cohort was significantly larger compared with the non-CPMs cohort (113.5 vs. 93.0 days;

=0.008).

Conclusion:

Adjuvant CPMs to standard therapy can significantly reduce the incidence of variceal rebleeding and delay the time to rebleeding.

关键词

Keywords

adjuvant therapyChinese patent medicinevariceal bleedingvariceal rebleeding

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