Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke

Wen-jie HAO; Bing-jie LI; Xiao-lei WU; Zhen-bo CHEN; Xin ZHANG; Han YAO; Wen-yan ZHANG; Xue-gong FENG

doi:10.1007/s11655-020-3325-y

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Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke

Clinical Experience | Updated：2021-09-01

- Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke
- Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke
- Chinese Journal of Integrative Medicine 2021年27卷第5期页码：369-374
- Affiliations：
  
  1.Department of Encephalopathy, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing (100039), China
  2.Department of Neurology, China Rehabilitation Research Center, Beijing (100068), China
  3.Department of Radiology, China Rehabilitation Research Center, Beijing(100068), China
  4.The 3rd Department of Neurorehabilitation, China Rehabilitation Research Center, Beijing (100068), China
- Author bio：
  
  Prof. FENG Xue-gong, E-mail: bjcwhfxg@sina.com
- Funds：
  
  the National Natural Science Foundation of China(81273705)
- DOI：10.1007/s11655-020-3325-y
  中图分类号：
- 纸质出版日期：2021-05-01，
  
  网络出版日期：2020-09-30，
  
  录用日期：2020-04-26
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Wen-jie HAO, Bing-jie LI, Xiao-lei WU, 等. Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke[J]. Chinese Journal of Integrative Medicine, 2021,27(5):369-374.

Wen-jie HAO, Bing-jie LI, Xiao-lei WU, et al. Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke[J]. Chinese Journal of Integrative Medicine, 2021,27(5):369-374.
Wen-jie HAO, Bing-jie LI, Xiao-lei WU, 等. Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke[J]. Chinese Journal of Integrative Medicine, 2021,27(5):369-374. DOI： 10.1007/s11655-020-3325-y.

Wen-jie HAO, Bing-jie LI, Xiao-lei WU, et al. Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke[J]. Chinese Journal of Integrative Medicine, 2021,27(5):369-374. DOI： 10.1007/s11655-020-3325-y.

摘要

Abstract

Objective:

To observe the effects and safety of Tongyan Spray (通咽喷雾剂) on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia.

Methods:

Seventy-two patients with ischemic post-stroke dysphagia were selected and randomly assigned to a treatment group (36 cases) and a control group (36 cases) by a random number table from January 2013 to October 2014. All patients swallowed 4 kinds of barium meals with different traits respectively

and each patient underwent video fluoroscopy (VF) examination twice. In the treatment group

Tongyan Spray was sprayed to the pharynx on both sides and the middle part once respectively. The spray was applied 30 min before the second examination. Purified water at room temperature was used as placebo in the control group. The changes in the range and time of hyoid motion in both groups were observed before and after treatment.

Results:

Six patients dropped out in each group

and 60 patients completed the study and were included in the final analysis. Significant improvement was observed in the range of superior hyoid excursion distance and the time of hyoid motion in the treatment group compared with the control group (

0.05). There were no obvious adverse reactions observed in oral mucosa in both groups during the whole study.

Conclusion:

Tongyan Spray was an effective and safe medicine for improving swallowing function in patients with ischemic post-stroke dysphagia.

关键词

Keywords

Tongyan Spraystrokedysphagiahyoid motionvideo fluoroscopyChinese medicine

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