Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults

Mark Levy; Jun-rong WU; Jian-pin SHI; Hao-jie CHENG; Xuan-qiao QU; Ira Bernstein; Robert Sinnott; Jun-qiang TIAN

doi:10.1007/s11655-020-3430-y

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Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults

Original Article | Updated：2021-09-01

- Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults
- Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults
- Chinese Journal of Integrative Medicine 2021年27卷第9期页码：666-673
- Affiliations：
  
  1.Research and Development Department, USANA Health Science, Inc., Salt Lake City, UT (84121), USA
  2.Elegant and Olive Health Clinic, Markham, ON (L3R 5V6), Canada
  3.Department of Family and Community Medicine, Humber River Hospital, Toronto, ON (M1V 2W7), Canada
- Author bio：
  
  Dr. TIAN Jun-qiang, E-mail: Jeremy.tian@us.usana.com
- Funds：
  
  USANA Health Science Inc.;the manufacturer of Proglucamune®
- DOI：10.1007/s11655-020-3430-y
  中图分类号：
- 纸质出版日期：2021-09-01，
  
  网络出版日期：2020-08-19，
  
  录用日期：2020-04-10
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Mark Levy, Jun-rong WU, Jian-pin SHI, 等. Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults[J]. Chinese Journal of Integrative Medicine, 2021,27(9):666-673.

Mark Levy, Jun-rong WU, Jian-pin SHI, et al. Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults[J]. Chinese Journal of Integrative Medicine, 2021,27(9):666-673.
Mark Levy, Jun-rong WU, Jian-pin SHI, 等. Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults[J]. Chinese Journal of Integrative Medicine, 2021,27(9):666-673. DOI： 10.1007/s11655-020-3430-y.

Mark Levy, Jun-rong WU, Jian-pin SHI, et al. Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults[J]. Chinese Journal of Integrative Medicine, 2021,27(9):666-673. DOI： 10.1007/s11655-020-3430-y.

摘要

Abstract

Objective:

To preliminarily explore the potential effect of β-glucan on Chinese medicine (CM) concept protective qi deficiency (PQD)

and the methodology for future definitive studies.

Methods:

To have a standardized assessment of PQD

a list of 13 potentially PQD-relevant parameters were firstly created

each with defined quantitative or categorial scales. Using the data from 37 participants with (21 cases) or without (16 cases) PQD

multivariate logistic modeling was conducted to create a preliminary diagnostic PQD risk score. Subsequently

21 participants diagnosed with PQD were treated with β-glucan in a dose of 200 mg/day for 8 weeks. Data were collected for trial acceptability measures (rate of recruitment

withdrawal

and compliance)

and the participants were assessed for PQD status at baseline and every 2 weeks thereafter.

Results:

The preliminary logistic model consisted of 3 parameters (low voice and apathy

aversion to wind and cold

and Cun pulse). The resulting risk score demonstrated a degree of PQD-predicting accuracy that

as evaluated by statistical (discrimination and classification) methods

was higher than those obtained from any of the individual candidate parameters. The 21 PQD participants treated with β-glucan demonstrated good receptibility and a time-dependent improvement in PQD status as evidenced by the decrease of PQD participant to 9.5% at the end of study.

Conclusions:

This study demonstrated the effect of proof-of-concept of β-glucan on improving PQD and the proof-of-concept of a multivariate-model-derived diagnostic PQD risk score. It also indicated feasibility for future definitive studies. Studies like this embody an innovative approach that uses therapies derived from the mainstream biomedicine to enrich therapeutics guided by CM principle. (Trial registration No. NCT03829228)

关键词

Keywords

β-glucanprotective qi deficiencyChinese medicinediagnostic risk score

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