Tanreqing Injection (痰热清注射液) for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Chen-chen QU; Guo-zhen ZHAO; Xiao-peng WANG; Xiao-long XU; Bo LI; Yu-hong GUO; Qing-quan LIU

doi:10.1007/s11655-020-3472-1

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Tanreqing Injection (痰热清注射液) for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Evidence-Based Integrative Medicine | Updated：2021-08-23

- Tanreqing Injection (痰热清注射液) for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Tanreqing Injection (痰热清注射液) for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Chinese Journal of Integrative Medicine 2020年26卷第12期页码：936-942
- Affiliations：
  
  1.Emergency Department of Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing (100010), China
  2.Beijing Institute of Traditional Chinese Medicine, Beijing (100010), China
  3.Capital Medical University, Beijing (100010), China
  4.Beijing University of Chinese Medicine, Beijing (100010), China
  5.Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing (100010), China
- Author bio：
  
  Correspondence to: Prof. LIU Qing-quan, E-mail:liuqingquan2003@126.com
- Funds：
  
  the National Natural Science Foundation of China(81673934;81774146);National Science and Technology Major Project of the Ministry of Science and Technology of China(2017ZX10305501001);Beijing Municipal Administration of Hospitals of Clinical Medicine Development of Special Funding Support(ZYLX201611)
- DOI：10.1007/s11655-020-3472-1
  中图分类号：
- 纸质出版日期：2020-12-01，
  
  网络出版日期：2020-06-22，
  
  录用日期：2019-06-14
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Chen-chen QU, Guo-zhen ZHAO, Xiao-peng WANG, 等. Tanreqing Injection (痰热清注射液) for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials[J]. Chinese Journal of Integrative Medicine, 2020,26(12):936-942.

Chen-chen QU, Guo-zhen ZHAO, Xiao-peng WANG, et al. Tanreqing Injection (痰热清注射液) for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials[J]. Chinese Journal of Integrative Medicine, 2020,26(12):936-942.
Chen-chen QU, Guo-zhen ZHAO, Xiao-peng WANG, 等. Tanreqing Injection (痰热清注射液) for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials[J]. Chinese Journal of Integrative Medicine, 2020,26(12):936-942. DOI： 10.1007/s11655-020-3472-1.

Chen-chen QU, Guo-zhen ZHAO, Xiao-peng WANG, et al. Tanreqing Injection (痰热清注射液) for Patients with Influenza: A Systematic Review and Meta-analysis of Randomized Controlled Trials[J]. Chinese Journal of Integrative Medicine, 2020,26(12):936-942. DOI： 10.1007/s11655-020-3472-1.

摘要

Abstract

Objective:

To systematically evaluate the efficacy and safety of Tanreqing Injection (痰热清注射液

TRQI) combined with conventional treatment on clinical outcomes in the treatment of patients with influenza.

Methods:

The electronic databases searched were Cochrane Central Register of Controlled Trials (CENTRAL

The Cochrane Library)

MEDLINE (PubMed)

EMbase (OvidSP)

Chinese Bio-medical Literature and Retrieval System (Sinomed)

China National Knowledge Infrastructure Database (CNKI)

China Science and Technology Journal Database (VIP) and WanFang Data Knowledge Service Platform

and we checked the reference sections of the retrieved articles as well. The search was performed in October 2018

and we used the randomized controlled trials (RCTs) that corresponded to the new diagnostic criteria for influenza. Two review authors independently screened the internalized articles in accordance with the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) statement checklist. We evaluated the quality of the articles and extracted the data from the studies using the Revmen5.3 software.

Results:

We included 12 RCTs of over 882 cases in this meta-analysis. Compared to conventional treatment

TRQI combined with conventional treatment could increase the total effective rate [9 RCTs

=648

odds ratio (OR): 4.92

95% confidence interval (CI): 2.94

8.24

0.0001

random effects model]

decrease the average time for fever clearance [7 RCTs

=564

mean difference (MD): –1.08

95% CI: –1.68

–0.48

=0.0004

random effects model] and decrease the time for resolution of cough (5 RCTs

=362

MD: –1.76

95% CI: –2.63

–0.90

0.0001

random effects model).

Conclusion:

Based on this meta-analysis of RCTs

TRQI combined with conventional treatment had a statistically significant benefit in increasing the total effective treatment rate and reducing the time for fever clearance as well as time for resolution of cough.

关键词

Keywords

influenzaTanreqing Injectionsystematic reviewmeta-analysisrandomized controlled trial

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