Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure

Li-jun GUO; Ke-ji CHEN; Ming-qian SUN; An-zhu WANG; Feng GAO; Yuan ZHENG; Xiao-chang MA

doi:10.1007/s11655-020-3479-7

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Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure

Original Article | Updated：2021-08-16

- Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure
- Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure
- Chinese Journal of Integrative Medicine 2021年27卷第4期页码：259-264
- Affiliations：
  
  1.Graduate School of Beijing University of Chinese Medicine, Beijing(100029), China
  2.Cardiovascular Disease Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
  3.Institute of Basic Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
- Author bio：
  
  Correspondence to: Prof. MA Xiao-chang, E-mail:maxiaochang@x263.net
- Funds：
  
  the National Natural Science Foundation of China
- DOI：10.1007/s11655-020-3479-7
  中图分类号：
- 纸质出版日期：2021-04-01，
  
  网络出版日期：2021-01-09，
  
  录用日期：2019-12-31
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Li-jun GUO, Ke-ji CHEN, Ming-qian SUN, 等. Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure[J]. Chinese Journal of Integrative Medicine, 2021,27(4):259-264.

Li-jun GUO, Ke-ji CHEN, Ming-qian SUN, et al. Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure[J]. Chinese Journal of Integrative Medicine, 2021,27(4):259-264.
Li-jun GUO, Ke-ji CHEN, Ming-qian SUN, 等. Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure[J]. Chinese Journal of Integrative Medicine, 2021,27(4):259-264. DOI： 10.1007/s11655-020-3479-7.

Li-jun GUO, Ke-ji CHEN, Ming-qian SUN, et al. Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure[J]. Chinese Journal of Integrative Medicine, 2021,27(4):259-264. DOI： 10.1007/s11655-020-3479-7.

摘要

Abstract

Objective:

To reveal the underlying relationships between Chinese medicine (CM) syndromes and ultrafiltration (UF) in the treatment of heart failure based on a metabonomic approach.

Methods:

Seventeen acute decompensated heart failure (ADHF) patients were enrolled

and their CM syndromes before and after UF were collected. In addition

their venous plasma collected before and after UF was used for liquid chromatographmass spectrometer-based metabonomic analysis. Both reversed phase liquid chromatography and hydrophilic interaction liquid chromatography were used to analyze the plasma samples. Partial least-squares to latent structure-discriminant analyses were used for data analysis.

Results:

An obvious difference was observed preand post-treatment. A total of 17 potential biomarkers associating with alterd syndromes with UF including hypoxanthine

1-methylhistidine

phytosphingosine

O-decanoyl-R-carnitine

etc. were screened out

showing a significant change after UF. The major adjusted metabolic pathways were purine metabolism

histidine metabolism

leucine and isoleucine metabolism

arginine and proline metabolism

carnitine shuttle

sphingolipid metabolism and phospholipid metabolism.

Conclusions:

Metabonomic approach is a useful tool to identify potential biomarkers of altered syndromes link to UF and could provide a theoretical basis for further research on the therapeutic mechanism of UF combined with CM.

关键词

Keywords

metabonomicsheart failureultrafiltrationChinese medicine

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