Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology

Gao-jie XIN; Yu-wei ZHAO; Ling-mei LI; Fei-fan JIA; Xiao HAN; Lei LI; Hao GUO; Hong-xu MENG; Jian-hua FU; Jian-xun LIU

doi:10.1007/s11655-021-2859-y

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Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology

Original Article | Updated：2021-09-01

- Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology
- Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology
- Chinese Journal of Integrative Medicine 2021年27卷第6期页码：440-445
- Affiliations：
  
  1.Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia, Beijing (100091), China
  2.National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
- Author bio：
  
  Prof. FU Jian-hua, E-mail:jianhuaffcn@263.net
- Funds：
  
  the National Natural Science Foundation of China(81774145);Youth Program of National Natural Science Foundation of China(81503292);National Key Basic Research and Development Program(2015cb554406)
- DOI：10.1007/s11655-021-2859-y
  中图分类号：
- 纸质出版日期：2021-06-01，
  
  网络出版日期：2021-01-09，
  
  录用日期：2020-08-25
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Gao-jie XIN, Yu-wei ZHAO, Ling-mei LI, 等. Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology[J]. Chinese Journal of Integrative Medicine, 2021,27(6):440-445.

Gao-jie XIN, Yu-wei ZHAO, Ling-mei LI, et al. Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology[J]. Chinese Journal of Integrative Medicine, 2021,27(6):440-445.
Gao-jie XIN, Yu-wei ZHAO, Ling-mei LI, 等. Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology[J]. Chinese Journal of Integrative Medicine, 2021,27(6):440-445. DOI： 10.1007/s11655-021-2859-y.

Gao-jie XIN, Yu-wei ZHAO, Ling-mei LI, et al. Mechanism of 'Invigorating Qi and Promoting Blood Circulation'Drug Pair Ginseng-Danshen on Treatment of Ischemic Heart Disease Based on Network Pharmacology[J]. Chinese Journal of Integrative Medicine, 2021,27(6):440-445. DOI： 10.1007/s11655-021-2859-y.

摘要

Abstract

Objective:

Using network pharmacology to explore the mechanism of the 'invigorating qi and promoting blood circulation' drug pair Ginseng-Danshen (

Salvia miltiorrhiza

) on treatment of ischemic heart disease (IHD).

Methods:

The chemical constituents of ginseng and Danshen drug pair were identified by searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP)

and the potential targets of the pair were identified. The pharmacodynamics of the pair was analyzed using network pharmacology. The targets of IHD were identified by database screening. Using protein-protein interaction network

the interaction targets of Ginseng-Danshen on IHD were constructed. A "constituent-target-disease" interaction network was constructed using Cytoscape software

Gene Ontology (GO) term enrichment analysis and biological pathway enrichment analysis were carried out

and the mechanism of improving myocardial ischemia by the Ginseng-Danshen drug pair was investigated.

Results:

Seventeen active constituents and 53 targets were identified from ginseng

53 active constituents and 61 targets were identified from Danshen

and 32 protein targets were shared by ginseng and Danshen. Twenty GO terms were analyzed

including cytokine receptor binding

cytokine activity

heme binding

and antioxidant activity. Sixty Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways were analyzed

including phosphatidylinositol 3-kinase-serine-threonine kinase (PI3K-AKT) signaling pathway

p53 signaling pathway

interleukin 17 signaling pathway

tumor necrosis factor signaling pathway

and the advanced glycation end product (AGE)-the receptor for AGE (RAGE) signaling pathway in diabetic complications.

Conclusion:

The specific mechanism of Ginseng-Danshen drug pair in treating IHD may be associated with improving the changes of metabolites inbody

inhibiting the production of peroxides

removing the endogenous oxygen free radicals

regulating the expression of inflammatory factors

reducing myocardial cell apoptosis and promoting vascular regeneration.

关键词

Keywords

network pharmacologyGinseng-DanshenSalvia miltiorrhizadrug pairischemic heart diseaseinvigorating qi and promoting blood circulation

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