Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine<sup>*</sup>

Guang-tao HU; Yong WANG

doi:10.1007/s11655-021-2864-1

Your Location：

Home >

Browse articles >

Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine^*

Review | Updated：2021-11-05

- Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine^*
- Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine^*
- Chinese Journal of Integrative Medicine 2021年27卷第11期页码：874-880
- Affiliations：
  
  1.Department of Psychological Medicine, Army 958th Hospital, Chongqing (400039), China
  2.Department of Traditional Chinese Medicine, Southwest Hospital, Army Medical University, Chongqing (400038), China
- Author bio：
  
  Prof. WANG Yong, E-mail: wangyongjhy@126.com.
- Funds：
  
  Key Issues of the Logistics Support Department of the Chinese People's Liberation Army Military Commission(BLJ19J009);Chongqing Science and Health Joint TCM Technology Key Project(ZY201801010)
- DOI：10.1007/s11655-021-2864-1
  中图分类号：
- 纸质出版日期：2021-11-01，
  
  网络出版日期：2021-05-31，
  
  录用日期：2020-09-28
Scan for full text
Guang-tao HU, Yong WANG. Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):874-880.

Guang-tao HU, Yong WANG. Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):874-880.
Guang-tao HU, Yong WANG. Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):874-880. DOI： 10.1007/s11655-021-2864-1.

Guang-tao HU, Yong WANG. Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):874-880. DOI： 10.1007/s11655-021-2864-1.

摘要

“及时、就近、期待”是军事战斗应激反应 (CSR) 战场救援的主要原则. 创伤后应激障碍 (PTSD) 是CSR最常见的形式

是一种由不寻常的威胁性或灾难性的心理创伤引起的长期持续的精神障碍. 中医药资源丰富

操作简单

易掌握

副作用少. 本文总结了中医药治疗PTSD的细胞和动物实验机制

提示中草药和针灸可以保护脑功能区

调节下丘脑-垂体-肾上腺轴. 传统中草药和针灸在临床应用中均显示出良好的抗应激效果和较少的副作用

可能会改善战场上的CSR.

Abstract

"Timely

near

and expectation" is the main principle of battlefield rescue for military combat stress reaction (CSR). Post-traumatic stress disorder (PTSD) is the most common form of CSR and a long-term persistent mental disorder that is caused by unusual threatening or catastrophic psychological trauma. Chinese medicine (CM) has abundant resources

is simple

easy to master

with few side effects. This article summarizes the cellular and animal experimental mechanisms of CM treatment on PTSD

suggesting that traditional Chinese herbs and acupuncture can protect brain functional areas

and adjust hypothalamus-pituitary-adrenal axis. Traditional Chinese herbs and acupuncture have shown good anti-stress efficacy and fewer side effects in clinical application

which may improve the CSR in the battlefield.

关键词

Keywords

combat stress reactionpost-traumatic stress disorderChinese medicineacupuncture treatment

references

Gan LY, Meng SP, Feng ZZ, et al. The epidemiologic characteristic and risk factors of depression symptom in military personnel in high and cold regions. Chongqing Med(Chin) 2013;42:1332-1335.

Gray GC, Kaiser KS, Hawksworth AW, et al. Increased postwar symptoms and psychological morbidity among US Navy Gulf War veterans．Am J Trop Med Hyg 1999;60:758-766.

Friedman MJ, Schnurr PP, McDonagh-Coyle A. Post-traumatic stress disorder in the military veteran. Psychiatr Clin North Am 1994;17:265-277.

Gindi S, Galili G, Volovic-Shushan S, et al. Integrating occupational therapy in treating combat stress reaction within a military unit: An intervention model. Work 2016;55:737-745.

Svetlitzky V, Farchi M, Ben Yehuda A, et al. YaHaLOM training in the military: Assessing knowledge, confidence, and stigma. Psychol Serv 2020;17:151-159.

Baker MT, Moring JC, Hale WJ, et al. Acute assessment of traumatic brain injury and post-traumatic stress after exposure to a deployment-related explosive blast. Mil Med 2018;183:e555-e563.

Wittchen HU, Gloster A, Beesdo K, et al. Posttraumatic stress disorder: diagnostic and epidemiological perspectives. CNS Spectr 2009;14(1 Suppl 1):5-12.

Ren Z, Guo J, Yang C. Loss of homeland: a qualitative study of the changes in perception of relocated Sichuan earthquake survivors with posttraumatic stress disorder.BMC Psychiatry 2020;20:392.

Liu DL, Chen H, Ma L, et al. Post-traumatic stress disorder and its predictors among bereaved Tibetan adolescents four years after the Yushu earthquake: a cross-sectional survey in China. J Clin Nurs 2017;26:1095-1105.

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. DSM-5. Philadedphia:2013:4189.

Vindegaard N, Benros ME. COVID-19 pandemic and mental health consequences: Systematic review of the current evidence. Brain Behav Immun 2020;89:531-542.

Cai GX. Emotional diseases. Beijing: People's Medical Publishing House; 2011:134.

Wei PK, Shi J, Wu F, et al. Bailong Jieyu Granule in treatment of post-traumatic stress disorder among rescuing soldiers of Wenchuan Earth-quake. J Second Mil Med Univ(Chin) 2010;31:921-922.

Sinclair-Lian N, Hollifield M, Menache M, et al. Developing a traditional Chinese medicine diagnostic structure for post-traumatic stress disorder. J Altern Complement Med 2006;12:45-57.

Baker ME, Funder JW, Kattoula SR. Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.J Steroid Biochem Mol Biol 2013;137:57-70.

Knox D, Nault T, Henderson C, et al. Glucocorticoid receptors and extinction retention deficits in the single prolonged stress model. Neuroscience 2012;223:163-173.

Krisztina J Kovács. CRH: the link between hormonal metabolic-and behavioral responses to stress. J Chem Neuroanat 2013;54:25-33.

Liberzon I, Abelson JL. Context processing and the neurobiology of post-traumatic stress disorder. Neuron 2016;92:14-30.

Wilson MA, Grillo CA, Fadel JR, et al. Stress as a one-armed bandit: differential effects of stress paradigms on the morphology, neurochemistry and behavior in the rodent amygdala. Neurobiol Stress 2015;1:195-208.

Hou LQ, Liu S, Xiong KR. Effect of electroacupuncture on hippocampal nNOS expression in rats of post-traumatic stress disorder model. Chin Acupunct Moxibust (Chin)2013;33:632-636.

Li M, Li K, Zhang H, et al. Study on the mechanism of TMRK electroacupuncture in repairing synaptic plasticity in amygdala and hippocampus to relieve fear memory in PTSD rats. Technol Health Care 2019;27(S1):425-443.

Peng Z, Wang H, Zhang R, et al. Gastrodin ameliorates anxiety-like behaviors and IL-1β level and p38 MAPK phosphoylation of hippocampus in the rat model of posttraumatic stress disorder. Physiol Res 2013;62:537-545.

Nie H, Peng Z, Lao N, et al. Rosmarinic acid ameliorates PTSD-like symptoms in a rat model and promotes cell proliferation in the hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 2014;51:16-22.

Herman JP, Cullinan WE. Neurocircuitry of stress: central control of the hypothalamo-pituitary adrenocortical axis.Trends Neurosci 1997;20:78-84.

Auxéméry Y. Post-traumatic psychiatric disorders: PTSD is not the only diagnosis. Presse Med 2018;47:423-430.

Li N, Tang QS, Zhao RZ, et al. Ethological changes in rats with chronic stress-induced anxiety and interventional effect of Danzhixiaoyao Powder. J Beijing Univ Tradit Chin Med(Chin) 2009;32:826-829.

Chen JX, Li Wei, Zhao X, et al. Effects of three Chinese formulas on BDNF, TrkB in rat contex and hippocampus with chronic immobilization stress. Chin J Pathophysiol(Chin) 2007;23:1296-1300.

Gao PF, Du YL, Xu YM, et al. Efficacy and mechanism of Chaihu and Longgu Muli Tang on posttraumatic stress disorder.Chin J Experi Tradit Med Formul (Chin) 2013;19:219-222.

Han F, Ding J, Shi Y. Expression of amygdala mineralocorticoid receptor and glucocorticoid receptor in the single-prolonged stress rats. BMC Neurosci 2014;15: 77.

Du Z, Han F, Shi YX. Expressions of hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor(GR) in the single-prolonged stress-rats. Acta Histochem Cytochem 2008;41:89-95.

Hu LL, Zhang YH, Su YG. Effects of Baihe Dihuang Decoction on behavior and GR/MR expression in hippocampus of rats with post traumatic stress disorder. Chin J Tradit Med Sci Technol (Chin) 2014;21:135-137.

Wang ZL, Zhu KX, Chen L, et al. Preventive effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD)-like behavior in male C57/B6 mice. Neurosci Lett 2015;605:24-28.

Fang YQ, Cai DJ, Zhou QZ, et al. Comparative research on intervention in anxiety behavior of PTSD-like rats by electroacupuncture and repetitive transcranial magnetic stimulation and serum corticosterone. J Nanjing Univ Tradit Chin Med (Natur Sci, Chin) 2012;28:357-359.

Yao H, Wei DN, Cai DJ, et al. Effects of acupuncture on ANP and CNP in adrenal gland and CORT in plasma in rats with chronic emotional stress anxiety. Chin Acupunct Moxibust 2016;36:169-174.

Wei PK, Xiu LJ, Pang B, et al. Effect of Bailong Jieyu Granule on the posttraumatic stress disorder due to earthquake. J Tradit Chin Med (Chin) 2010;5:510-512.

Meng XZ, Wu F, Wei PK, et al. A Chinese herbal formula to improve general psychological status in posttraumatic stress disorder: A randomized placebo-controlled trial on Sichuan arthquake survivors. Evid Based Complement Altern Med 2012;2012:691258.

Numata T, Gunfan S, Takayama S, et al. Treatment of posttraumatic stress disorder using the traditional Japanese herbal medicine saikokeishikankyoto: A randomized, observer-blinded, controlled trial in survivors of the Great East Japan earthquake and tsunami. Evid Based Complement Altern Med 2014; 2014:683293.

Lin JG, Chan YY, Chen YH. Acupuncture for the treatment of opiate addiction. Evid Based Complement Altern Med 2012;2012:739045.

Rometsch-Ogioun El, Sount C, Windthorst P, et al. Chronic pain in refugees with posttraumatic stress disorder (PTSD):A systematic review on patients' characteristics and specific interventions. J Psychosom Res 2019;118:83-97.

Xu JY, Wang FQ, Liu QA, et al. The influence of traditional Chinese medicine and acupuncture on SDS and SAS of anti-terrorism exercise personnel. Med Chin People's Armed Police Forces (Chin) 2004;15:940-941.

Zhao MJ, Zhang JT, Guo HY, et al. Analysis of 33 cases of military mental stress response intervened by acupuncture and brain wave therapy. Med J Chin People's Liberation Army (Chin) 2011;36:982.

Grant S, Colaiaco B, Motala A, et al. Acupuncture for the treatment of adults with posttraumatic stress disorder:A systematic review and meta-analysis. J Trauma Dissociation 2018;19:39-58.

Ozakinci G, Hallman WK, Kipen HM. Persistence of symptoms in veterans of the First Gulf War: 5-year follow-up. Environ Health Perspect 2006;114:1553-1537.

Karen P. Anxiety, depression and acupuncture: A review of the clinical research. Auton Neurosci 2010;157:91-95.

Asher GN, Gerkin J, Gaynes BN. Complementary therapies for mental health disorders. Med Clin North Am 2017;101:847-864.

Wendling P. Acupuncture lessens PTSD, depression, pain in veterans [N/OL]. (2008-12-15) [11] [2013-05-04].http://psych.imng.com/filead-min/content_pdf/imn/archive_pdf/vol4iss24/71340_main.pdfhttp://psych.imng.com/filead-min/content_pdf/imn/archive_pdf/vol4iss24/71340_main.pdf.

Hollifield M, Sinclair-Lian N, Warner T D, et al. Acupuncture for posttraumatic stress disorder: a randomized controlled pilot trial. J Nerv Ment Dis 2007;195:504-513.

Conboy L, Gerke T, Hsu KY, et al. The effectiveness of individualized acupuncture protocols in the treatment of Gulf War Illness: A pragmatic randomized clinical trial.PLoS One 2016;11:e0149161.

Zhang H, Chen WW, Song WZ, et al. Brain glucose metabolism involved in acupuncture treatment on posttraumatic stress disorder. Chin J Tradit Chin Med Pharm (Chin) 2010;25:1882-1884.

Zhang H, Yuan CF, Ran LH, et al. RCT research of different acupuncture therapies in treating posttraumatic stress disorder after Wenchuan'5.12'earthquake. Chin J Tradit Chin Med Pharm (Chin) 2010; 25:1505-1510.

Zhao GJ, Liu MY, Guo SY, et al. Observation on therapeutic effect of electroacupuncture at Baihui-Dazhui point on post-traumatic stress disorder. J Clin Acupunct Moxibust (Chin)2014;30:31-33.

Huang LJ, Luo WJ, Zhu H, et al. Effect of wrist-ankle acupuncture on post traumatic stress disorder after work-related injury. Chin J Rehabilit Theory Pract (Chin)2012;18:855-857.

Hong C, Efferth T. Systematic review on post-traumatic stress disorder among survivors of the Wenchuan earthquake. Trauma Violence Abuse 2016;17:542-561.

Moiraghi C, Poli P, Piscitelli A. An observational study on acupuncture for earthquake-related post-traumatic stress disorder: The experience of the lombard association of medical acupuncturists/acupuncture in the world, in Amatrice, Central Italy. Med Acupunct 2019;31:116-122.

Lochmann D, Richardson T. Selective serotonin reuptake inhibitors. Handb Exp Pharmacol 2019;250:135-144.

Woroń J, Siwek M, Gorostowicz A. Adverse effects of interactions between antidepressants and medications used in treatment of cardiovascular disorders. Psychiatr Pol 2019;53:977-995.

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini

Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16-F10, MC38 and Hep1-6 Tumor Models

Safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/β-Catenin Signaling Pathway

Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice