Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis<sup>*</sup>

Qi-qi XIN; Xun CHEN; Rong YUAN; Ya-hui YUAN; Jia-qi HUI; Yu MIAO; Wei-hong CONG; Ke-ji CHEN

doi:10.1007/s11655-021-2871-2

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Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*

Evidence-Based Integrative Medicine | Updated：2021-11-05

- Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*
- Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*
- Chinese Journal of Integrative Medicine 2021年27卷第11期页码：858-866
- Affiliations：
  
  1.Laboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
  2.National Clinical Research Center for Chinese Medicine Cardiology, Beijing (100091), China
  3.Department of Clinical Laboratory, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), China
- Author bio：
  
  Prof. CONG Wei-hong, E-mail: congcao@188.com
- Funds：
  
  the Authorized Project of China Academy of Chinese Medical Sciences(ZZ13-036-4);the Special Fund of Xiyuan Hospital of China Academy of Chinese Medical Sciences for the Cultivation of the National Natural Science Foundation of China(XY20-01)
- DOI：10.1007/s11655-021-2871-2
  中图分类号：
- 纸质出版日期：2021-11-01，
  
  网络出版日期：2021-09-16，
  
  录用日期：2021-01-18
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Qi-qi XIN, Xun CHEN, Rong YUAN, 等. Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):858-866.

Qi-qi XIN, Xun CHEN, Rong YUAN, et al. Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):858-866.
Qi-qi XIN, Xun CHEN, Rong YUAN, 等. Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):858-866. DOI： 10.1007/s11655-021-2871-2.

Qi-qi XIN, Xun CHEN, Rong YUAN, et al. Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease:A Systematic Review and Meta-Analysis^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):858-866. DOI： 10.1007/s11655-021-2871-2.

摘要

目的:

探讨冠心病血瘀证与血小板、凝血功能的相关性.

方法:

本研究方案已于PROSPERO网站注册(CRD42019129452). 检索PubMed、Embase、Cochrane图书馆和中国知网数据库

纳入包含冠心病血瘀证和非血瘀证患者并提供血小板和凝血功能信息的相关研究

检索时间截止到2020年6月1日. 通过森林图比较冠心病血瘀证与非血瘀症患者的血小板功能、凝血功能和纤溶活性差异. 通过亚组分析、敏感性分析以探索异质性的来源.

结果:

共检索出1583篇论文

经过筛选最终纳入30项试验、涉及10323名患者. meta分析结果显示

血瘀证组平均血小板体积、血小板分布宽度、血小板聚集率、P-选择素、纤维蛋白原、纤溶酶原激活物抑制剂-1 (PAI-1)、血栓素B2 (TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)、TXB2/6-keto-PGF1α均高于非血瘀证组(

0.05或

0.01). 在冠心病急性期

血瘀证组活化部分凝血活酶时间低于非血瘀证组(

0.01). 血瘀证组组织纤溶酶原激活物(t-PA)和t-PA/PAI-1、R、K值均低于非血瘀证组(均

0.01). 两组间血小板计数、血小板压积、血栓弹力图最大振幅、血管性血友病因子、凝血酶原时间、凝血酶时间、国际标准化比值等结果无统计学差异.

结论:

与冠心病非血瘀证患者相比

血瘀证患者呈现出血小板功能亢进、高凝、纤溶活性降低的特点.

Abstract

Objective:

To investigate the correlation of platelet and coagulation function with blood stasis syndrome (BSS) in coronary heart disease (CHD).

Methods:

The protocol for this meta-analysis was registered on PROSPERO (CRD42019129452). PubMed

Excerpta Medica Database (Embase)

the Cochrane Library

and China National Knowledge Infrastructure (CNKI) were searched from inception to 1st June

2020. Trials were considered eligible if they enrolled BSS and non-BSS (NBSS) patients with CHD and provided information on platelet and coagulation function. The platelet function

coagulation function

and fibrinolytic activity were compared between the BSS and NBSS groups. Forest plots were generated to show the SMDs or ESs with corresponding 95% CIs for each study. Subgroup analysis and sensitivity analysis were performed to explore potential sources of heterogeneity.

Results:

The systematic search identified 1

583 articles. Thirty trials involving 10

323 patients were included in the meta-analysis. The results showed that mean platelet volume

platelet distribution width

platelet aggregation rate

platelet P selectin

fibrinogen

plasminogen activator inhibitor-1 (PAI-1)

thromboxane B2 (TXB2)

6-keto-prostaglandin F1alpha (6-keto-PGF1α)

and TXB2/6-keto-PGF1α were higher in the BSS group than in the NBSS group (

0.05 or

0.01). Activated partial thromboplastin time was lower in the BSS group than in the NBSS group in the acute phase of CHD (

0.01). The R and K values in thromboelastography and tissue plasminogen activator (t-PA) and t-PA/PAI-1 were lower in the BSS group than in the NBSS group (all

0.01). No difference was found in the results of platelet count

plateletcrit

maximum amplitude

von Willebrand factor

prothrombin time

thrombin time

international normalized ratio

etc. between groups.

Conclusions:

Increased platelet function

hypercoagulability

and decreased fibrinolytic activity were found among CHD patients with BSS.

关键词

Keywords

coronary heart diseaseblood stasis syndromeplateletcoagulation

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