Effects of Danhong Injection (丹红注射液) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study<sup>*</sup>

Wen-long XING; Yong-jian WU; Hong-xu LIU; Qing-rong LIU; Qi ZHOU; Ai-yong LI; Zhu-hua ZHANG; Xuan LI

doi:10.1007/s11655-021-2872-1

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Effects of Danhong Injection (丹红注射液) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study^*

Clinical Experience | Updated：2021-11-05

- Effects of Danhong Injection (丹红注射液) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study^*
- Effects of Danhong Injection (丹红注射液) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study^*
- Chinese Journal of Integrative Medicine 2021年27卷第11期页码：846-853
- Affiliations：
  
  1.Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing (100010), China
  2.Department of Cardiology, Fuwai Hospital, Beijing(100037), China
- Author bio：
  
  Prof. LIU Hong-xu, E-mail: lhx_@263.net
- Funds：
  
  Beijing Municipal Administration of Hospitals Key Medical Professional Development Program(ZYLX201817);Capital Health Development Research Project(2014-2-4032)
- DOI：10.1007/s11655-021-2872-1
  中图分类号：
- 纸质出版日期：2021-11-01，
  
  网络出版日期：2021-07-14，
  
  录用日期：2020-09-25
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Wen-long XING, Yong-jian WU, Hong-xu LIU, 等. Effects of Danhong Injection (丹红注射液) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):846-853.

Wen-long XING, Yong-jian WU, Hong-xu LIU, et al. Effects of Danhong Injection (丹红注射液) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):846-853.
Wen-long XING, Yong-jian WU, Hong-xu LIU, 等. Effects of Danhong Injection (丹红注射液) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):846-853. DOI： 10.1007/s11655-021-2872-1.

Wen-long XING, Yong-jian WU, Hong-xu LIU, et al. Effects of Danhong Injection (丹红注射液) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study^*[J]. Chinese Journal of Integrative Medicine, 2021,27(11):846-853. DOI： 10.1007/s11655-021-2872-1.

摘要

目的:

评价丹红注射液对不稳定型心绞痛择期经皮冠状动脉介入治疗 (PCI) 患者围手术期心肌损伤及冠脉微循环阻力的影响.

方法:

78例不稳定型心绞痛择期PCI患者随机分为丹红组 (DH

39例) 和对照组 (39例) . 采用随机数字表法进行分组

DH组在PCI期间给予DH 40ml (混合生理盐水250ml

用避光袋遮挡

静脉滴注)

术后继予每日1次

连续7天; 对照组用同样方法予等量生理盐水. 两组均接受规范化治疗

在PCI术前、后测定患者冠脉微循环阻力指数 (IMR) 和血流储备分数 (FFR) . 患者术前及术后24小时检测心肌标志物

包括肌红蛋白、肌酸激酶 (CK) 、肌酸激酶MB (CK-MB) 和肌钙蛋白T (cTnT) .

结果:

入选的78例患者中

两组的基线资料和介入操作特点无差异. 两组PCI术前心肌损伤标志物及冠脉生理学指标均无统计学差异

DH组PCI术后CK、CK-MB水平低于对照组并具有统计学差异 (111.97±80.97vs.165.47±102.99

P=0.013; 13.08±6.90vs.19.75±15.49

P=0.016) . DH组PCI术后肌红蛋白和cTNT阳性率低于对照组

但无统计学差异 (88.07±52.36vs.108.13±90.94

P=0.52; 2.56% vs.7.69%

P=0.065) . 与对照组相比

DH组IMR后水平有下降趋势

但无统计学差异 (20.73±13.15 vs.26.37±12.31

P=0.05) . 术后FFR两者无统计学差异. DH组PCI围手术期心肌损伤发生率低于对照组

具有统计学差异 (2.56% vs.15.38%

P=0.025) . 在术后30天的随访期间

两组均未发生MACEs事件.

结论:

DH对减轻不稳定型心绞痛择期PCI患者围手术期心肌损伤及改善微血管功能具有一定作用.

Abstract

Objective:

To evaluate the effect of Danhong Injection (丹红注射液

DH) on the index of microcirculatory resistance (IMR) and myocardial injury in patients with unstable angina undergoing elective percutaneous coronary intervention (PCI).

Methods:

Seventy-eight patients with unstable angina were randomly divided into DH group (39 cases) and the control group (39 cases) during elective PCI. Randomization was performed using a random-number table. The DH group received DH at a dosage of 40 mL (mixed with 250 mL saline

covered by a light-proof bag

intravenous drip) during PCI and daily for 7 consecutive days

while the control group only received the same dosage of saline. Both groups received standardized treatment. The IMR and fractional flow reserve (FFR) were measured at maximal hyperemia before and after PCI. Myocardial markers

including myoglobin

creatine kinase (CK)

creatine kinase MB (CK-MB)

and coronary troponin T (cTnT) values were measured at baseline and 24 h after PCI.

Results:

Among the 78 patients enrolled

the baseline and procedural characteristics were similar between the two groups. There was no significant difference in pre-PCI myocardial markers and coronary physiological indexes between the two groups. However

post-PCI CK and CK-MB levels in the DH group were significantly lower than those in the control group (111.97±80.97 vs. 165.47±102.99

=0.013; 13.08±6.90 vs. 19.75±15.49

=0.016). Post-PCI myoglobin and cTNT-positive tend to be lower in the DH group than in the control group but did not reach statistical significance (88.07±52.36 vs. 108.13±90.94

=0.52; 2.56% vs.7.69%

=0.065). Compared with the control group

the post-IMR levels of the DH group tended to decrease

but there was no statistical difference (20.73±13.15 vs. 26.37±12.31

=0.05). There were no statistical differences in post-FFR in both groups. The peri-procedural myocardial injury of the DH group was significantly lower than that of the control group (2.56% vs. 15.38%

=0.025). During the 30-d follow-up period

no major adverse cardiovascular events occurred in either group.

Conclusion:

This study demonstrated benefit of DH in reducing myocardial injury and potential preserving microvascular function in patients with unstable angina undergoing elective PCI.

关键词

Keywords

peri-procedural myocardial injurypercutaneous coronary interventionmicrocirculatory resistancemicrovascular dysfunction

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