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Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase SignalingRumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling- Chinese Journal of Integrative Medicine 2022年28卷第9期 页码：802-808
- Affiliations：
1.Laboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu(41566), Republic of Korea
2.Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science(NIHHS), Eumseong (27709), Republic of Korea
- Author bio：
Man Hee Rhee, E-mail: rheemh@knu.ac.kr
- Funds：a grant of National Research Foundation of Korea(2018R1D1A1A09083797)
DOI：10.1007/s11655-021-2873-0
中图分类号：纸质出版日期：2022-09，
网络出版日期：2021-09-21，
录用日期：2020-04-02
Scan for full text
Bo-Ra Jeon, Muhammad Irfan, Seung Eun Lee, 等.
Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling[J]. Chinese Journal of Integrative Medicine, 2022,28(9):802-808.Bo-Ra Jeon, Muhammad Irfan, Seung Eun Lee, et al.
Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling[J]. Chinese Journal of Integrative Medicine, 2022,28(9):802-808.Bo-Ra Jeon, Muhammad Irfan, Seung Eun Lee, 等.
Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling[J]. Chinese Journal of Integrative Medicine, 2022,28(9):802-808. DOI： 10.1007/s11655-021-2873-0.Bo-Ra Jeon, Muhammad Irfan, Seung Eun Lee, et al.
Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling[J]. Chinese Journal of Integrative Medicine, 2022,28(9):802-808. DOI： 10.1007/s11655-021-2873-0.
摘要
Abstract
Objective:
2
To examine the antiplatelet and antithrombotic activity of
Rumex acetosella
extract.
Methods:
2
Standard light aggregometry was used for platelet aggregation
intracellular calcium mobilization assessed using Fura-2/AM
granule secretion (ATP release) by luminometer
and fibrinogen binding to integrin α
Ⅱb
β
3
detected using flow cytometry. Western blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/Akt signaling.
Results:
2
Rumex acetosella
displayed the ability to inhibit platelet aggregation
calcium mobilization
granule secretion
and fibrinogen binding to integrin α
Ⅱb
β
3
.
Rumex acetosella
has also down-regulated MAPK and PI3K/Akt phosphorylation (all
P
<
0.01).
Conclusion:
2
Rumex acetosella
extract exhibits antiplatelet activity via modulating GPVI signaling
and it may protect against the development of platelet-related cardiovascular diseases.
关键词
Keywords
antiplateletethnomedicineintegrin αⅡbβ3mitogen-activated protein kinaseRumex acetosella L.
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