Correlation between Characteristics of Coronary Plaque and Chinese Medicine Syndromes of Coronary Heart Disease: A Cross-Sectional Study Analysed by Intravascular Ultrasound

Dan-ping XU; Jun-peng XU; Zhi-ling HE; Guang-ming PAN; Xia WANG

doi:10.1007/s11655-021-2874-z

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Correlation between Characteristics of Coronary Plaque and Chinese Medicine Syndromes of Coronary Heart Disease: A Cross-Sectional Study Analysed by Intravascular Ultrasound

Clinical Experience | Updated：2022-09-08

- Correlation between Characteristics of Coronary Plaque and Chinese Medicine Syndromes of Coronary Heart Disease: A Cross-Sectional Study Analysed by Intravascular Ultrasound
- Correlation between Characteristics of Coronary Plaque and Chinese Medicine Syndromes of Coronary Heart Disease: A Cross-Sectional Study Analysed by Intravascular Ultrasound
- Chinese Journal of Integrative Medicine 2022年28卷第9期页码：840-846
- Affiliations：
  
  1.Department of Cardiology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou(510120), China
  2.Postdoctoral Station of Fujian University of Chinese Medicine, Fuzhou (350122), China
  3.The Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou (510120), China
- Author bio：
  
  Dr. WANG Xia, E-mail: chenrkgd@126.com
- Funds：
  
  the National Natural Science Foundation of China(81774219);Guangdong Provincial Science and Technology Plan(201710010107);Traditional Chinese Medicine Science and Technology Research Project of Traditional Chinese Medicine Hospital of Guangdong Province(YN2014LN06)
- DOI：10.1007/s11655-021-2874-z
  中图分类号：
- 纸质出版日期：2022-09，
  
  网络出版日期：2022-01-19，
  
  录用日期：2020-06-12
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Dan-ping XU, Jun-peng XU, Zhi-ling HE, 等. Correlation between Characteristics of Coronary Plaque and Chinese Medicine Syndromes of Coronary Heart Disease: A Cross-Sectional Study Analysed by Intravascular Ultrasound[J]. Chinese Journal of Integrative Medicine, 2022,28(9):840-846.

Dan-ping XU, Jun-peng XU, Zhi-ling HE, et al. Correlation between Characteristics of Coronary Plaque and Chinese Medicine Syndromes of Coronary Heart Disease: A Cross-Sectional Study Analysed by Intravascular Ultrasound[J]. Chinese Journal of Integrative Medicine, 2022,28(9):840-846.
Dan-ping XU, Jun-peng XU, Zhi-ling HE, 等. Correlation between Characteristics of Coronary Plaque and Chinese Medicine Syndromes of Coronary Heart Disease: A Cross-Sectional Study Analysed by Intravascular Ultrasound[J]. Chinese Journal of Integrative Medicine, 2022,28(9):840-846. DOI： 10.1007/s11655-021-2874-z.

Dan-ping XU, Jun-peng XU, Zhi-ling HE, et al. Correlation between Characteristics of Coronary Plaque and Chinese Medicine Syndromes of Coronary Heart Disease: A Cross-Sectional Study Analysed by Intravascular Ultrasound[J]. Chinese Journal of Integrative Medicine, 2022,28(9):840-846. DOI： 10.1007/s11655-021-2874-z.

摘要

Abstract

Objective:

To analyse the correlation between the characteristics of coronary plaque in coronary heart disease (CHD) patients with phlegm-blood stasis syndrome (PBS) and blood stasis syndrome (BSS).

Methods:

Patients were divided into different groups based on Chinese medicine (CM) syndrome differentiation. The baseline demographics and clinical variables were collected from the medical records. Additionally

the characteristics of plaque and pathological manifestations in coronary artery were evaluated using intravascular ultrasound (IVUS).

Results:

A total of 213 CHD patients were enrolled in two groups: 184 were diagnosed with PBS and the remaining 29 were diagnosed with BSS. There were no significant differences in age

body mass index

proportions of patients with high blood pressure

diabetes mellitus

smoking

hyperlipidemia

history of coronary artery bypass graft and percutaneous coronary intervention

medications

index from cardiac ultrasound image

blood lipids and C-reactive protein between the two groups (

0.05)

except gender

weight and proportions of IVUS observed target vessels (

0.05 or

0.01). More adverse events such as acute myocardial infarction (

=0.003) and unstable angina (

=0.048) were observed in BSS. Additionally

dissection

thrombus and coronary artery ectasia were significantly increased in BSS (

0.05 or

0.01). In contrast

PBS had more patients with stable angina and chronic total occlusion with significantly higher SYNTAX (synergy between percutaneous coronary intervention with Taxus and coronary artery bypass surgery) scores (

0.05 or

0.01). Moreover

dense-calcium was significantly elevated in PBS (

0.01).

Conclusions:

Coronary plaque characteristics were correlated with different CM syndromes. Patients with PBS were associated with a higher degree of calcified plaque and severe coronary artery stenosis

indicating poor clinical prognosis but with a low probability of acute coronary events. In contrast

the degree of calcified plaque in patients with BSS remained relatively low

and plaque was more vulnerable

resulting in the possibility of the occurrence of acute coronary events remaining high.

关键词

Keywords

coronary heart diseasecoronary plaqueintravascular ultrasoundChinese medicine syndromesyndrome differentiation

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